Literature DB >> 29017049

Exploiting the Hidden Treasure of Detained Introns.

Xiang-Dong Fu1.   

Abstract

Many mammalian genes contain poorly spliced introns, resulting in nuclear detention of partially spliced transcripts, which may be exploited to modulate gene expression. In this issue of Cancer Cell, Braun et al. report that the arginine methyltransferase PRMT5 is critical for tumor cell proliferation by regulating numerous detained introns.
Copyright © 2017 Elsevier Inc. All rights reserved.

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Year:  2017        PMID： 29017049      PMCID： PMC5967397          DOI： 10.1016/j.ccell.2017.09.005

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  9 in total

1.  An alternative splicing network links cell-cycle control to apoptosis.

Authors:  Michael J Moore; Qingqing Wang; Caleb J Kennedy; Pamela A Silver
Journal:  Cell       Date:  2010-08-12       Impact factor: 41.582

2.  RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.

Authors:  Gernot Guderian; Christoph Peter; Julia Wiesner; Albert Sickmann; Klaus Schulze-Osthoff; Utz Fischer; Matthias Grimmler
Journal:  J Biol Chem       Date:  2010-11-16       Impact factor: 5.157

3.  Arginine methylation controls the subcellular localization and functions of the oncoprotein splicing factor SF2/ASF.

Authors:  Rahul Sinha; Eric Allemand; Zuo Zhang; Rotem Karni; Michael P Myers; Adrian R Krainer
Journal:  Mol Cell Biol       Date:  2010-03-22       Impact factor: 4.272

4.  The gene encoding the splicing factor SF2/ASF is a proto-oncogene.

Authors:  Rotem Karni; Elisa de Stanchina; Scott W Lowe; Rahul Sinha; David Mu; Adrian R Krainer
Journal:  Nat Struct Mol Biol       Date:  2007-02-18       Impact factor: 15.369

5.  Widespread intron retention in mammals functionally tunes transcriptomes.

Authors:  Ulrich Braunschweig; Nuno L Barbosa-Morais; Qun Pan; Emil N Nachman; Babak Alipanahi; Thomas Gonatopoulos-Pournatzis; Brendan Frey; Manuel Irimia; Benjamin J Blencowe
Journal:  Genome Res       Date:  2014-09-25       Impact factor: 9.043

6.  Detained introns are a novel, widespread class of post-transcriptionally spliced introns.

Authors:  Paul L Boutz; Arjun Bhutkar; Phillip A Sharp
Journal:  Genes Dev       Date:  2015-01-01       Impact factor: 11.361

7.  Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma.

Authors:  Christian J Braun; Monica Stanciu; Paul L Boutz; Jesse C Patterson; David Calligaris; Fumi Higuchi; Rachit Neupane; Silvia Fenoglio; Daniel P Cahill; Hiroaki Wakimoto; Nathalie Y R Agar; Michael B Yaffe; Phillip A Sharp; Michael T Hemann; Jacqueline A Lees
Journal:  Cancer Cell       Date:  2017-09-28       Impact factor: 38.585

8.  The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x.

Authors:  Maria Paola Paronetto; Tilman Achsel; Autumn Massiello; Charles E Chalfant; Claudio Sette
Journal:  J Cell Biol       Date:  2007-03-19       Impact factor: 10.539

9.  Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins.

Authors:  Stanley Chun-Wei Lee; Heidi Dvinge; Eunhee Kim; Hana Cho; Jean-Baptiste Micol; Young Rock Chung; Benjamin H Durham; Akihide Yoshimi; Young Joon Kim; Michael Thomas; Camille Lobry; Chun-Wei Chen; Alessandro Pastore; Justin Taylor; Xujun Wang; Andrei Krivtsov; Scott A Armstrong; James Palacino; Silvia Buonamici; Peter G Smith; Robert K Bradley; Omar Abdel-Wahab
Journal:  Nat Med       Date:  2016-05-02       Impact factor: 53.440
  9 in total
  3 in total

1.  Meta-Analysis Suggests That Intron Retention Can Affect Quantification of Transposable Elements from RNA-Seq Data.

Authors:  Nicolò Gualandi; Cristian Iperi; Mauro Esposito; Federico Ansaloni; Stefano Gustincich; Remo Sanges
Journal:  Biology (Basel)       Date:  2022-05-27

2.  Splicing of platelet resident pre-mRNAs upon activation by physiological stimuli results in functionally relevant proteome modifications.

Authors:  Giovanni Nassa; Giorgio Giurato; Giovanni Cimmino; Francesca Rizzo; Maria Ravo; Annamaria Salvati; Tuula A Nyman; Yafeng Zhu; Mattias Vesterlund; Janne Lehtiö; Paolo Golino; Alessandro Weisz; Roberta Tarallo
Journal:  Sci Rep       Date:  2018-01-11       Impact factor: 4.379

Review 3.  The Analysis of the Human Megakaryocyte and Platelet Coding Transcriptome in Healthy and Diseased Subjects.

Authors:  Koenraad De Wispelaere; Kathleen Freson
Journal:  Int J Mol Sci       Date:  2022-07-11       Impact factor: 6.208
  3 in total

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