Literature DB >> 4033759

Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer.

P S Ohashi, T W Mak, P Van den Elsen, Y Yanagi, Y Yoshikai, A F Calman, C Terhorst, J D Stobo, A Weiss.   

Abstract

We have introduced a full-length complementary DNA of the T-cell antigen receptor beta-chain into a mutant human T-cell line that lacked a complete beta-chain messenger RNA, had a diminished level of alpha-chain transcript and did not express surface T3- or antigen receptor. Expression of the transfected beta-chain led to a normal level of alpha-chain transcript and a structurally and functionally active T3 T-cell antigen receptor complex on the cell surface.

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Year:  1985        PMID： 4033759     DOI： 10.1038/316606a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  89 in total

1.  The membrane IgM-associated proteins MB-1 and Ig-beta are sufficient to promote surface expression of a partially functional B-cell antigen receptor in a nonlymphoid cell line.

Authors:  L Matsuuchi; M R Gold; A Travis; R Grosschedl; A L DeFranco; R B Kelly
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-15       Impact factor: 11.205

2.  CD3 zeta dependence of the CD2 pathway of activation in T lymphocytes and natural killer cells.

Authors:  P Moingeon; J L Lucich; D J McConkey; F Letourneur; B Malissen; J Kochan; H C Chang; H R Rodewald; E L Reinherz
Journal:  Proc Natl Acad Sci U S A       Date:  1992-02-15       Impact factor: 11.205

Review 3.  Structure and function of the T cell antigen receptor.

Authors:  A Weiss
Journal:  J Clin Invest       Date:  1990-10       Impact factor: 14.808

4.  Antigen/major histocompatibility complex-specific activation of murine T cells transfected with functionally rearranged T-cell receptor genes.

Authors:  C L Kuo; L Hood
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205

5.  Single-chain VαVβ T-cell receptors function without mispairing with endogenous TCR chains.

Authors:  D H Aggen; A S Chervin; T M Schmitt; B Engels; J D Stone; S A Richman; K H Piepenbrink; B M Baker; P D Greenberg; H Schreiber; D M Kranz
Journal:  Gene Ther       Date:  2011-07-14       Impact factor: 5.250

6.  Negative trans-regulation of T-cell antigen receptor/T3 complex mRNA expression in murine T-lymphoma somatic cell hybrids.

Authors:  C L MacLeod; L Minning; D P Gold; C Terhorst; M Wilkinson
Journal:  Proc Natl Acad Sci U S A       Date:  1986-09       Impact factor: 11.205

7.  A novel loop domain in superantigens extends their T cell receptor recognition site.

Authors:  Sebastian Günther; Ashok K Varma; Beenu Moza; Katherine J Kasper; Aaron W Wyatt; Penny Zhu; A K M Nur-ur Rahman; Yili Li; Roy A Mariuzza; John K McCormick; Eric J Sundberg
Journal:  J Mol Biol       Date:  2007-05-18       Impact factor: 5.469

8.  Expression of membrane interleukin 1 by fibroblasts transfected with murine pro-interleukin 1 alpha cDNA.

Authors:  R C Fuhlbrigge; S M Fine; E R Unanue; D D Chaplin
Journal:  Proc Natl Acad Sci U S A       Date:  1988-08       Impact factor: 11.205

9.  Expression of T-cell receptor alpha-chain genes in transgenic mice.

Authors:  L J Berg; B Fazekas de St Groth; F Ivars; C C Goodnow; S Gilfillan; H J Garchon; M M Davis
Journal:  Mol Cell Biol       Date:  1988-12       Impact factor: 4.272

10.  Therapeutic potential of a tumor-specific, MHC-unrestricted T-cell receptor expressed on effector cells of the innate and the adaptive immune system through bone marrow transduction and immune reconstitution.

Authors:  Nehad M Alajez; Jan Schmielau; Mark D Alter; Michael Cascio; Olivera J Finn
Journal:  Blood       Date:  2005-03-03       Impact factor: 22.113
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