Literature DB >> 2901093

Parathyroid hormone modulates transforming growth factor beta activity and binding in osteoblast-enriched cell cultures from fetal rat parietal bone.

M Centrella1, T L McCarthy, E Canalis.   

Abstract

Transforming growth factor beta (TGF-beta) is produced by bone cells, is abundant in bone matrix, and regulates bone cell biochemical processes. In osteoblast-enriched fetal rat parietal bone cell cultures, low TGF-beta doses increase DNA synthesis, whereas higher levels are less mitogenic, stimulate collagen production, and decrease alkaline phosphatase activity. Parathyroid hormone by itself has minimal effects on these processes, but it opposes the effects of TGF-beta and alters TGF-beta binding to its receptors in osteoblast-enriched cultures. Some functions ascribed to parathyroid hormone in bone may therefore result from alterations in TGF-beta activity, suggesting that the local effects of TGF-beta in bone are under systemic hormonal control.

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Year:  1988        PMID： 2901093      PMCID： PMC281870          DOI： 10.1073/pnas.85.16.5889

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  23 in total

Review 1.  Local regulators of skeletal growth: a perspective.

Authors:  M Centrella; E Canalis
Journal:  Endocr Rev       Date:  1985       Impact factor: 19.871

2.  Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone.

Authors:  M Centrella; T L McCarthy; E Canalis
Journal:  J Biol Chem       Date:  1987-02-25       Impact factor: 5.157

3.  Modulation of type beta transforming growth factor activity in bone cultures by osteotropic hormones.

Authors:  J Pfeilschifter; G R Mundy
Journal:  Proc Natl Acad Sci U S A       Date:  1987-04       Impact factor: 11.205

4.  Structure and properties of the cellular receptor for transforming growth factor type beta.

Authors:  B O Fanger; L M Wakefield; M B Sporn
Journal:  Biochemistry       Date:  1986-06-03       Impact factor: 3.162

5.  Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-Sepharose.

Authors:  P V Hauschka; A E Mavrakos; M D Iafrati; S E Doleman; M Klagsbrun
Journal:  J Biol Chem       Date:  1986-09-25       Impact factor: 5.157

6.  Mitogenesis in fetal rat bone cells simultaneously exposed to type beta transforming growth factor and other growth regulators.

Authors:  M Centrella; T L McCarthy; E Canalis
Journal:  FASEB J       Date:  1987-10       Impact factor: 5.191

7.  Transforming and nontransforming growth factors are present in medium conditioned by fetal rat calvariae.

Authors:  M Centrella; E Canalis
Journal:  Proc Natl Acad Sci U S A       Date:  1985-11       Impact factor: 11.205

8.  Cartilage-inducing factor-A. Apparent identity to transforming growth factor-beta.

Authors:  S M Seyedin; A Y Thompson; H Bentz; D M Rosen; J M McPherson; A Conti; N R Siegel; G R Galluppi; K A Piez
Journal:  J Biol Chem       Date:  1986-05-05       Impact factor: 5.157

9.  Cellular distribution of type I and type II receptors for transforming growth factor-beta.

Authors:  S Cheifetz; B Like; J Massagué
Journal:  J Biol Chem       Date:  1986-07-25       Impact factor: 5.157

10.  Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro.

Authors:  P G Robey; M F Young; K C Flanders; N S Roche; P Kondaiah; A H Reddi; J D Termine; M B Sporn; A B Roberts
Journal:  J Cell Biol       Date:  1987-07       Impact factor: 10.539
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  14 in total

Review 1.  Growth factors and the skeletal system.

Authors:  E Canalis; T L McCarthy; M Centrella
Journal:  J Endocrinol Invest       Date:  1989-09       Impact factor: 4.256

Review 2.  Parathyroid hormone in the treatment of involutional osteoporosis: back to the future.

Authors:  J Y Reginster; A N Taquet; G Fraikin; C Gosset; B Zegels
Journal:  Osteoporos Int       Date:  1997       Impact factor: 4.507

3.  Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures.

Authors:  E Canalis; M Centrella; W Burch; T L McCarthy
Journal:  J Clin Invest       Date:  1989-01       Impact factor: 14.808

4.  Differential expression of ryanodine receptor RyR2 mRNA in the non-pregnant and pregnant human myometrium.

Authors:  S S Awad; H K Lamb; J M Morgan; W Dunlop; J I Gillespie
Journal:  Biochem J       Date:  1997-03-15       Impact factor: 3.857

5.  Recombinant transforming growth factor type beta 3: biological activities and receptor-binding properties in isolated bone cells.

Authors:  P ten Dijke; K K Iwata; C Goddard; C Pieler; E Canalis; T L McCarthy; M Centrella
Journal:  Mol Cell Biol       Date:  1990-09       Impact factor: 4.272

6.  Stimulation of creatine kinase activity in rat skeletal tissue in vivo and in vitro by protease-resistant variants of parathyroid hormone fragments.

Authors:  D Sömjen; V Vargas; A Waisman; E Wingender; W Tegge; A M Kaye
Journal:  Biochem J       Date:  1995-07-01       Impact factor: 3.857

7.  Activin-A binding and biochemical effects in osteoblast-enriched cultures from fetal-rat parietal bone.

Authors:  M Centrella; T L McCarthy; E Canalis
Journal:  Mol Cell Biol       Date:  1991-01       Impact factor: 4.272

8.  Ultrasound exposure during pregnancy affects rabbit foetal parathyroid hormone (PTH) level.

Authors:  Sulaiman Md Dom; Hairil Rashmizal Abdul Razak; Farah Wahida Ahmad Zaiki; Nurul Hidayah Saat; Khairunnisa Abd Manan; Iza Nurzawani Che Isa; Ummi Farhana Hashim
Journal:  Quant Imaging Med Surg       Date:  2013-02

9.  Independent changes in type I and type II receptors for transforming growth factor beta induced by bone morphogenetic protein 2 parallel expression of the osteoblast phenotype.

Authors:  M Centrella; S Casinghino; J Kim; T Pham; V Rosen; J Wozney; T L McCarthy
Journal:  Mol Cell Biol       Date:  1995-06       Impact factor: 4.272

10.  Glucocorticoid regulation of transforming growth factor beta 1 activity and binding in osteoblast-enriched cultures from fetal rat bone.

Authors:  M Centrella; T L McCarthy; E Canalis
Journal:  Mol Cell Biol       Date:  1991-09       Impact factor: 4.272
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