| Literature DB >> 28993833 |
Chen Liang1,2,3, Si Shi1,2,3, Qingcai Meng1,2,3, Dingkong Liang1,2,3, Shunrong Ji1,2,3, Bo Zhang1,2,3, Yi Qin1,2,3, Jin Xu1,2,3, Quanxing Ni1,2,3, Xianjun Yu4,5,6.
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is among the most devastating human malignancies, with approximately 20-30% of PDAC patients receiving the surgical resection with curative intent. Although many studies have focused on finding ideal "drug chaperones" that facilitate and/or potentiate the effects of gemcitabine (GEM) in pancreatic cancer, a significant benefit in overall survival could not be demonstrated for any of these combination therapies in PDAC. Given that pancreatic cancer is characterized by desmoplasia and the dual biological roles of stroma in pancreatic cancer, we reassess the importance of stroma in GEM-based therapeutic approaches in light of current findings. This review is focused on understanding the role of stromal components in the extrinsic resistance to GEM and whether anti-stroma therapies have a positive effect on the GEM delivery. This work contributes to the development of novel and promising combination GEM-based regimens that have achieved significant survival benefits for the patients with pancreatic cancer.Entities:
Keywords: Drug delivery; Gemcitabine; Hyaluronan; Nab-paclitaxel; Pancreatic cancer; Stroma
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Year: 2017 PMID： 28993833 DOI： 10.1007/s00018-017-2678-7
Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261