Literature DB >> 24937454

Pancreatic cancer stroma: friend or foe?

Jesse Gore1, Murray Korc2.   

Abstract

Pancreatic cancer desmoplasia is thought to confer biological aggressiveness. In this issue of Cancer Cell, Özdemir and colleagues and Rhim and colleagues demonstrate that targeting the stroma results in undifferentiated, aggressive pancreatic cancer that responds to checkpoint blockade or antiangiogenic therapy, uncovering a protective role by stroma in this cancer.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Year:  2014        PMID： 24937454      PMCID： PMC4821630          DOI： 10.1016/j.ccr.2014.05.026

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  9 in total

1.  Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival.

Authors:  Berna C Özdemir; Tsvetelina Pentcheva-Hoang; Julienne L Carstens; Xiaofeng Zheng; Chia-Chin Wu; Tyler R Simpson; Hanane Laklai; Hikaru Sugimoto; Christoph Kahlert; Sergey V Novitskiy; Ana De Jesus-Acosta; Padmanee Sharma; Pedram Heidari; Umar Mahmood; Lynda Chin; Harold L Moses; Valerie M Weaver; Anirban Maitra; James P Allison; Valerie S LeBleu; Raghu Kalluri
Journal:  Cancer Cell       Date:  2014-05-22       Impact factor: 31.743

2.  Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States.

Authors:  Lola Rahib; Benjamin D Smith; Rhonda Aizenberg; Allison B Rosenzweig; Julie M Fleshman; Lynn M Matrisian
Journal:  Cancer Res       Date:  2014-06-01       Impact factor: 12.701

3.  Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma.

Authors:  Andrew D Rhim; Paul E Oberstein; Dafydd H Thomas; Emily T Mirek; Carmine F Palermo; Stephen A Sastra; Erin N Dekleva; Tyler Saunders; Claudia P Becerra; Ian W Tattersall; C Benedikt Westphalen; Jan Kitajewski; Maite G Fernandez-Barrena; Martin E Fernandez-Zapico; Christine Iacobuzio-Donahue; Kenneth P Olive; Ben Z Stanger
Journal:  Cancer Cell       Date:  2014-05-22       Impact factor: 31.743

4.  Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma.

Authors:  Paolo P Provenzano; Carlos Cuevas; Amy E Chang; Vikas K Goel; Daniel D Von Hoff; Sunil R Hingorani
Journal:  Cancer Cell       Date:  2012-03-20       Impact factor: 31.743

Review 5.  A starring role for stellate cells in the pancreatic cancer microenvironment.

Authors:  Minoti V Apte; Jeremy S Wilson; Aurelia Lugea; Stephen J Pandol
Journal:  Gastroenterology       Date:  2013-06       Impact factor: 22.682

Review 6.  Definition and classification of cancer cachexia: an international consensus.

Authors:  Kenneth Fearon; Florian Strasser; Stefan D Anker; Ingvar Bosaeus; Eduardo Bruera; Robin L Fainsinger; Aminah Jatoi; Charles Loprinzi; Neil MacDonald; Giovanni Mantovani; Mellar Davis; Maurizio Muscaritoli; Faith Ottery; Lukas Radbruch; Paula Ravasco; Declan Walsh; Andrew Wilcock; Stein Kaasa; Vickie E Baracos
Journal:  Lancet Oncol       Date:  2011-02-04       Impact factor: 41.316

Review 7.  Targeting angiogenesis in pancreatic cancer: rationale and pitfalls.

Authors:  Chery Whipple; Murray Korc
Journal:  Langenbecks Arch Surg       Date:  2008-01-22       Impact factor: 3.445

Review 8.  Genetically engineered mouse models of pancreatic adenocarcinoma.

Authors:  Carmen Guerra; Mariano Barbacid
Journal:  Mol Oncol       Date:  2013-02-11       Impact factor: 6.603

9.  Signatures of mutational processes in human cancer.

Authors:  Ludmil B Alexandrov; Serena Nik-Zainal; David C Wedge; Samuel A J R Aparicio; Sam Behjati; Andrew V Biankin; Graham R Bignell; Niccolò Bolli; Ake Borg; Anne-Lise Børresen-Dale; Sandrine Boyault; Birgit Burkhardt; Adam P Butler; Carlos Caldas; Helen R Davies; Christine Desmedt; Roland Eils; Jórunn Erla Eyfjörd; John A Foekens; Mel Greaves; Fumie Hosoda; Barbara Hutter; Tomislav Ilicic; Sandrine Imbeaud; Marcin Imielinski; Marcin Imielinsk; Natalie Jäger; David T W Jones; David Jones; Stian Knappskog; Marcel Kool; Sunil R Lakhani; Carlos López-Otín; Sancha Martin; Nikhil C Munshi; Hiromi Nakamura; Paul A Northcott; Marina Pajic; Elli Papaemmanuil; Angelo Paradiso; John V Pearson; Xose S Puente; Keiran Raine; Manasa Ramakrishna; Andrea L Richardson; Julia Richter; Philip Rosenstiel; Matthias Schlesner; Ton N Schumacher; Paul N Span; Jon W Teague; Yasushi Totoki; Andrew N J Tutt; Rafael Valdés-Mas; Marit M van Buuren; Laura van 't Veer; Anne Vincent-Salomon; Nicola Waddell; Lucy R Yates; Jessica Zucman-Rossi; P Andrew Futreal; Ultan McDermott; Peter Lichter; Matthew Meyerson; Sean M Grimmond; Reiner Siebert; Elías Campo; Tatsuhiro Shibata; Stefan M Pfister; Peter J Campbell; Michael R Stratton
Journal:  Nature       Date:  2013-08-14       Impact factor: 49.962
  9 in total
  82 in total

1.  Development of a Tumor-Responsive Nanopolyplex Targeting Pancreatic Cancer Cells and Stroma.

Authors:  Yuanke Li; Zhen Zhao; Hao Liu; John Peter Fetse; Akshay Jain; Chien-Yu Lin; Kun Cheng
Journal:  ACS Appl Mater Interfaces       Date:  2019-11-26       Impact factor: 9.229

2.  BET inhibitors block pancreatic stellate cell collagen I production and attenuate fibrosis in vivo.

Authors:  Krishan Kumar; Brian T DeCant; Paul J Grippo; Rosa F Hwang; David J Bentrem; Kazumi Ebine; Hidayatullah G Munshi
Journal:  JCI Insight       Date:  2017-02-09

3.  Tissue Transglutaminase Mediated Tumor-Stroma Interaction Promotes Pancreatic Cancer Progression.

Authors:  Jiyoon Lee; Salvatore Condello; Bakhtiyor Yakubov; Robert Emerson; Andrea Caperell-Grant; Kiyotaka Hitomi; Jingwu Xie; Daniela Matei
Journal:  Clin Cancer Res       Date:  2015-06-03       Impact factor: 12.531

4.  Antifibrotic Therapy Disrupts Stromal Barriers and Modulates the Immune Landscape in Pancreatic Ductal Adenocarcinoma.

Authors:  Kianna Y Elahi-Gedwillo; Marjorie Carlson; Jon Zettervall; Paolo P Provenzano
Journal:  Cancer Res       Date:  2018-11-06       Impact factor: 12.701

5.  The prognostic value of stroma in pancreatic cancer in patients receiving adjuvant therapy.

Authors:  Katherine M Bever; Elizabeth A Sugar; Elaine Bigelow; Rajni Sharma; Daniel Laheru; Christopher L Wolfgang; Elizabeth M Jaffee; Robert A Anders; Ana De Jesus-Acosta; Lei Zheng
Journal:  HPB (Oxford)       Date:  2014-09-23       Impact factor: 3.647

6.  The Binding Site Barrier Elicited by Tumor-Associated Fibroblasts Interferes Disposition of Nanoparticles in Stroma-Vessel Type Tumors.

Authors:  Lei Miao; Jay M Newby; C Michael Lin; Lu Zhang; Feifei Xu; William Y Kim; M Gregory Forest; Samuel K Lai; Matthew I Milowsky; Sara E Wobker; Leaf Huang
Journal:  ACS Nano       Date:  2016-09-28       Impact factor: 15.881

7.  Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation.

Authors:  Yan Wang; Jung-Mao Hsu; Ya'an Kang; Yongkun Wei; Pei-Chih Lee; Shing-Jyh Chang; Yi-Hsin Hsu; Jennifer L Hsu; Hung-Ling Wang; Wei-Chao Chang; Chia-Wei Li; Hsin-Wei Liao; Shih-Shin Chang; Weiya Xia; How-Wen Ko; Chao-Kai Chou; Jason B Fleming; Huamin Wang; Rosa F Hwang; Yue Chen; Jun Qin; Mien-Chie Hung
Journal:  Cancer Res       Date:  2016-10-06       Impact factor: 12.701

Review 8.  Tumor cross-talk networks promote growth and support immune evasion in pancreatic cancer.

Authors:  Christopher J Halbrook; Marina Pasca di Magliano; Costas A Lyssiotis
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2018-03-15       Impact factor: 4.052

9.  Pancreatic Tumor Microenvironment.

Authors:  Kai Wang; Hong He
Journal:  Adv Exp Med Biol       Date:  2020       Impact factor: 2.622

Review 10.  Key players in pancreatic cancer-stroma interaction: Cancer-associated fibroblasts, endothelial and inflammatory cells.

Authors:  Michael Friberg Bruun Nielsen; Michael Bau Mortensen; Sönke Detlefsen
Journal:  World J Gastroenterol       Date:  2016-03-07       Impact factor: 5.742
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