Literature DB >> 2899381

Histamine dependent cyclic AMP generating system in rabbit CNS: interaction with neuroregulators and forskolin.

B Sek1, A Sebastjanska, J Z Nowak.   

Abstract

Histamine (HI) potently stimulated, through H2-receptors, cAMP accumulation in rabbit cerebral cortical slices but not in retinal pieces. The action of HI in the cerebral cortex was not significantly affected by dopamine, serotonin, melatonin and GABA-ergic drugs. Forskolin markedly stimulated cAMP accumulation both in the cerebral cortex and retina. There was a synergistic interaction between HI and forskolin in the cerebral cortex, whereas in the retina HI decreased the forskolin-activated cAMP accumulation.

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Year:  1988        PMID: 2899381     DOI: 10.1007/bf02142551

Source DB:  PubMed          Journal:  Agents Actions        ISSN: 0065-4299


  7 in total

1.  Pharmacological characterization of histamine receptors mediating the stimulation of cyclic AMP accumulation in slices from guinea-pig hippocampus.

Authors:  J M Palacios; M Garbarg; G Barbin; J C Schwartz
Journal:  Mol Pharmacol       Date:  1978-11       Impact factor: 4.436

2.  A simple and sensitive saturation assay method for the measurement of adenosine 3':5'-cyclic monophosphate.

Authors:  B L Brown; J D Albano; R P Ekins; A M Sgherzi
Journal:  Biochem J       Date:  1971-02       Impact factor: 3.857

3.  Studies on adenosine 3',5'-phosphate in rabbit cerebral cortex.

Authors:  S Kakiuchi; T W Rall
Journal:  Mol Pharmacol       Date:  1968-07       Impact factor: 4.436

4.  Histamine dependent cAMP generating system in rabbit CNS: interaction with various neuroregulators.

Authors:  B Sek; A Sebastjanska; J Z Nowak
Journal:  Agents Actions       Date:  1987-04

5.  Activation of cyclic AMP-generating systems in brain membranes and slices by the diterpene forskolin: augmentation of receptor-mediated responses.

Authors:  J W Daly; W Padgett; K B Seamon
Journal:  J Neurochem       Date:  1982-02       Impact factor: 5.372

6.  Characterization of histamine receptors mediating the stimulation of cyclic AMP accumulation in rabbit cerebral cortical slices.

Authors:  M Al-Gadi; S J Hill
Journal:  Br J Pharmacol       Date:  1985-08       Impact factor: 8.739

Review 7.  Histaminergic mechanisms in the vertebrate visual system.

Authors:  J Z Nowak
Journal:  Pol J Pharmacol Pharm       Date:  1985 Nov-Dec
  7 in total
  1 in total

1.  Histamine-mediated regulation of cAMP levels and inositol phosphate metabolism in isolated rabbit retina.

Authors:  J Z Nowak; B Sek; B Szkiel
Journal:  Agents Actions       Date:  1989-04
  1 in total

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