Steven R Nesheim1, Jeffrey Wiener, Lauren F Fitz Harris, Margaret A Lampe, Paul J Weidle. 1. *Centers for Disease Control and Prevention/National Center for HIV, Viral Hepatitis, Sexually Transmitted Diseases and Tuberculosis Prevention/Division of HIV/AIDS Prevention/Epidemiology Branch; †Centers for Disease Control and Prevention/National Center for HIV, Viral Hepatitis, Sexually Transmitted Diseases and Tuberculosis Prevention/Division of HIV/AIDS Prevention, Quantitative, Statistical and Data Management Branch; and ‡Centers for Disease Control and Prevention/National Center for HIV, Viral Hepatitis, Sexually Transmitted Diseases and Tuberculosis Prevention/Division of HIV/AIDS Prevention/Epidemiology Branch, ICF International.
Abstract
BACKGROUND: An incidence of perinatally acquired HIV infection less than 1:100,000 live births is one of the Centers for Disease Control and Prevention (CDC) goals of the United States. Such an estimate has only been possible in recent years because regular nationwide data were lacking. METHOD: Using previously published CDC estimates of the number of infants born with HIV infection in the United States (interpolating for years for which there was no published estimate), and census data on the annual number of live-born infants, estimated incidence was calculated for 1978-2013. Exact 95% confidence intervals (CIs) were calculated using the Poisson distribution. RESULTS: Estimated incidence of perinatally acquired HIV infection peaked at 43.1 (95% CI: 41.1 to 45.1) in 1992 and declined rapidly after the use of zidovudine prophylaxis was recommended in 1994. In 2013, estimated incidence of perinatally acquired HIV infection in the United States was 1.8 (95% CI: 1.4 to 2.2), a 96% decline since the peak. CONCLUSION: Estimated incidence of perinatally acquired HIV infection in the United States in 2013 was 1.8/100,000 live births.
BACKGROUND: An incidence of perinatally acquired HIV infection less than 1:100,000 live births is one of the Centers for Disease Control and Prevention (CDC) goals of the United States. Such an estimate has only been possible in recent years because regular nationwide data were lacking. METHOD: Using previously published CDC estimates of the number of infants born with HIV infection in the United States (interpolating for years for which there was no published estimate), and census data on the annual number of live-born infants, estimated incidence was calculated for 1978-2013. Exact 95% confidence intervals (CIs) were calculated using the Poisson distribution. RESULTS: Estimated incidence of perinatally acquired HIV infection peaked at 43.1 (95% CI: 41.1 to 45.1) in 1992 and declined rapidly after the use of zidovudine prophylaxis was recommended in 1994. In 2013, estimated incidence of perinatally acquired HIV infection in the United States was 1.8 (95% CI: 1.4 to 2.2), a 96% decline since the peak. CONCLUSION: Estimated incidence of perinatally acquired HIV infection in the United States in 2013 was 1.8/100,000 live births.
Authors: M L Lindegren; R H Byers; P Thomas; S F Davis; B Caldwell; M Rogers; M Gwinn; J W Ward; P L Fleming Journal: JAMA Date: 1999-08-11 Impact factor: 56.272
Authors: Allan W Taylor; Steven R Nesheim; Xinjian Zhang; Ruiguang Song; Lauren F FitzHarris; Margaret A Lampe; Paul J Weidle; Patricia Sweeney Journal: JAMA Pediatr Date: 2017-05-01 Impact factor: 16.193
Authors: Kristen M Little; Allan W Taylor; Craig B Borkowf; Maria C B Mendoza; Margaret A Lampe; Paul J Weidle; Steven R Nesheim Journal: Pediatr Infect Dis J Date: 2017-01 Impact factor: 2.129
Authors: Lisa B Haddad; Kristin M Wall; C Christina Mehta; Elizabeth T Golub; Lisa Rahangdale; Mirjam-Colette Kempf; Roksana Karim; Rodney Wright; Howard Minkoff; Mardge Cohen; Seble Kassaye; Deborah Cohan; Igho Ofotokun; Susan E Cohn Journal: Am J Obstet Gynecol Date: 2016-09-15 Impact factor: 8.661
Authors: Steven Nesheim; Allan Taylor; Margaret A Lampe; Peter H Kilmarx; Lauren Fitz Harris; Suzanne Whitmore; Judy Griffith; Melissa Thomas-Proctor; Kevin Fenton; Jonathan Mermin Journal: Pediatrics Date: 2012-09-03 Impact factor: 7.124
Authors: D H Watts; M Lu; B Thompson; R E Tuomala; W A Meyer; H Mendez; K Rich; C Hanson; P LaRussa; C Diaz; L M Mofenson Journal: Infect Dis Obstet Gynecol Date: 2009-11-02
Authors: Mary-Margaret Andrews; Deborah S Storm; Carolyn K Burr; Erika Aaron; Mary Jo Hoyt; Anne Statton; Shannon Weber Journal: Public Health Rep Date: 2018-08-10 Impact factor: 2.792
Authors: Carmen D Zorrilla; Linnette Rodríguez-Figueroa; Sandra Miranda-De León; Bernardita López-Alvarado; Eileen Pérez; Silvia E Rabionet Journal: P R Health Sci J Date: 2021-03 Impact factor: 0.705