| Literature DB >> 2899153 |
R Hamel1, A W Ford-Hutchinson.
Abstract
Rat calcitonin gene-related peptide was shown to be a very potent contractile agent on guinea-pig trachea, contractions being observed at 10 pM and maximal contractions (32-36% of the methacholine maximum) being observed between 0.3 and 13.3 nM. The response was largely inhibited (88%) by pretreatment with indomethacin indicating that the effect was mediated through the secondary generation of cyclooxygenase products.Entities:
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Year: 1988 PMID： 2899153 DOI： 10.1111/j.2042-7158.1988.tb05222.x
Source DB: PubMed Journal: J Pharm Pharmacol ISSN： 0022-3573 Impact factor: 3.765