Literature DB >> 2611481

Arachidonic acid-induced bronchomotor responses are partially mediated by release of sensory neuropeptides from capsaicin-sensitive structures.

S Manzini1, L Ballati, P Geppetti, I Rubini, S Meini, F Perretti.   

Abstract

Administration of arachidonic acid (AA) both in vitro and in vivo elicited prominent contractile responses in guinea-pig airways, which were markedly reduced after capsaicin desensitization. Furthermore, AA superfusion elicited a significant calcitonin gene-related peptide-like immunoreactivity release from isolated bronchi. It is suggested that at least part of the bronchomotor actions of AA rely upon stimulation of capsaicin-sensitive primary afferents.

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Year:  1989        PMID： 2611481      PMCID： PMC1854805          DOI： 10.1111/j.1476-5381.1989.tb12649.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  13 in total

1.  Capsaicin desensitization protects from antigen-induced bronchospasm in conscious guinea-pigs.

Authors:  S Manzini; C A Maggi; P Geppetti; C Bacciarelli
Journal:  Eur J Pharmacol       Date:  1987-06-19       Impact factor: 4.432

2.  Predominant generation of 15-lipoxygenase metabolites of arachidonic acid by epithelial cells from human trachea.

Authors:  J A Hunter; W E Finkbeiner; J A Nadel; E J Goetzl; M J Holtzman
Journal:  Proc Natl Acad Sci U S A       Date:  1985-07       Impact factor: 11.205

3.  Contractile activity of calcitonin gene-related peptide on pulmonary tissues.

Authors:  R Hamel; A W Ford-Hutchinson
Journal:  J Pharm Pharmacol       Date:  1988-03       Impact factor: 3.765

4.  Involvement of capsaicin-sensitive afferent neurones in a vagal-dependent interaction between leukotriene D4 and histamine on bronchomotor tone.

Authors:  A G Stewart; D C Thompson; M R Fennessy
Journal:  Agents Actions       Date:  1984-12

5.  E-type prostaglandins depolarize primary afferent neurons of the neonatal rat.

Authors:  M Yanagisawa; M Otsuka; J E García-Arrarás
Journal:  Neurosci Lett       Date:  1986-08-04       Impact factor: 3.046

6.  Asthma as an axon reflex.

Authors:  P J Barnes
Journal:  Lancet       Date:  1986-02-01       Impact factor: 79.321

Review 7.  The sensory-efferent function of capsaicin-sensitive sensory neurons.

Authors:  C A Maggi; A Meli
Journal:  Gen Pharmacol       Date:  1988

8.  Sensory nerves containing tachykinins and CGRP in the lower airways. Functional implications for bronchoconstriction, vasodilatation and protein extravasation.

Authors:  C R Martling
Journal:  Acta Physiol Scand Suppl       Date:  1987

9.  Calcitonin gene-related peptide is localised to human airway nerves and potently constricts human airway smooth muscle.

Authors:  J B Palmer; F M Cuss; P K Mulderry; M A Ghatei; D R Springall; A Cadieux; S R Bloom; J M Polak; P J Barnes
Journal:  Br J Pharmacol       Date:  1987-05       Impact factor: 8.739

10.  Pharmacological modulation of responses of guinea-pig airways contracted with arachidonic acid.

Authors:  J F Burka
Journal:  Br J Pharmacol       Date:  1985-06       Impact factor: 8.739
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  4 in total

1.  The endogenous cannabinoid agonist, anandamide stimulates sensory nerves in guinea-pig airways.

Authors:  R C Tucker; M Kagaya; C P Page; D Spina
Journal:  Br J Pharmacol       Date:  2001-03       Impact factor: 8.739

2.  Comparison of the effects of intra-arterial and aerosol administration of endothelin-1 (ET-1) in the guinea-pig isolated lung.

Authors:  F Pons; C Touvay; V Lagente; J M Mencia-Huerta; P Braquet
Journal:  Br J Pharmacol       Date:  1991-04       Impact factor: 8.739

3.  Involvement of capsaicin-sensitive nerves in the bronchomotor effects of arachidonic acid and melittin: a possible role for lipoxin A4.

Authors:  S Manzini; S Meini
Journal:  Br J Pharmacol       Date:  1991-05       Impact factor: 8.739

4.  In vivo pharmacological evaluation of compound 48/80-induced airways oedema by MRI.

Authors:  H Karmouty-Quintana; F-X Blé; C Cannet; S Zurbruegg; J R Fozard; C P Page; N Beckmann
Journal:  Br J Pharmacol       Date:  2008-05-12       Impact factor: 8.739
  4 in total

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