M J Peffers1, P Balaskas2, A Smagul3. 1. Institute of Ageing and Chronic Disease, William Henry Duncan Building, 6 West Derby Street, Liverpool, L7 8TX, UK. Electronic address: peffs@liv.ac.uk. 2. Institute of Ageing and Chronic Disease, William Henry Duncan Building, 6 West Derby Street, Liverpool, L7 8TX, UK. Electronic address: panbalas@liverpool.ac.uk. 3. Institute of Ageing and Chronic Disease, William Henry Duncan Building, 6 West Derby Street, Liverpool, L7 8TX, UK. Electronic address: aibek@liverpool.ac.uk.
Abstract
OBJECTIVE: The purpose of this review is to describe highlights from original research publications related to osteoarthritis (OA), epigenetics and genomics with the intention of recognising significant advances. DESIGN: To identify relevant papers a Pubmed literature search was conducted for articles published between April 2016 and April 2017 using the search terms 'osteoarthritis' together with 'genetics', 'genomics', 'epigenetics', 'microRNA', 'lncRNA', 'DNA methylation' and 'histone modification'. RESULTS: The search term OA generated almost 4000 references. Publications using the combination of descriptors OA and genetics provided the most references (82 references). However this was reduced compared to the same period in the previous year; 8.1-2.1% (expressed as a percentage of the total publications combining the terms OA and genetics). Publications combining the terms OA with genomics (29 references), epigenetics (16 references), long non-coding RNA (lncRNA) (11 references; including the identification of novel lncRNAs in OA), DNA methylation (21 references), histone modification (3 references) and microRNA (miR) (79 references) were reviewed. Potential OA therapeutics such as histone deacetylase (HDAC) inhibitors have been identified. A number of non-coding RNAs may also provide targets for future treatments. CONCLUSION: There continues to be a year on year increase in publications researching miRs in OA (expressed as a percentage of the total publications), with a doubling over the last 4 years. An overview on the last year's progress within the fields of epigenetics and genomics with respect to OA will be given.
OBJECTIVE: The purpose of this review is to describe highlights from original research publications related to osteoarthritis (OA), epigenetics and genomics with the intention of recognising significant advances. DESIGN: To identify relevant papers a Pubmed literature search was conducted for articles published between April 2016 and April 2017 using the search terms 'osteoarthritis' together with 'genetics', 'genomics', 'epigenetics', 'microRNA', 'lncRNA', 'DNA methylation' and 'histone modification'. RESULTS: The search term OA generated almost 4000 references. Publications using the combination of descriptors OA and genetics provided the most references (82 references). However this was reduced compared to the same period in the previous year; 8.1-2.1% (expressed as a percentage of the total publications combining the terms OA and genetics). Publications combining the terms OA with genomics (29 references), epigenetics (16 references), long non-coding RNA (lncRNA) (11 references; including the identification of novel lncRNAs in OA), DNA methylation (21 references), histone modification (3 references) and microRNA (miR) (79 references) were reviewed. Potential OA therapeutics such as histone deacetylase (HDAC) inhibitors have been identified. A number of non-coding RNAs may also provide targets for future treatments. CONCLUSION: There continues to be a year on year increase in publications researching miRs in OA (expressed as a percentage of the total publications), with a doubling over the last 4 years. An overview on the last year's progress within the fields of epigenetics and genomics with respect to OA will be given.
Authors: M Chu; X Zhu; C Wang; J Rong; Y Wang; S Wang; B Xing; Y Tao; X Zhuang; L Jiang Journal: Osteoarthritis Cartilage Date: 2017-01-12 Impact factor: 6.576
Authors: Wouter den Hollander; Cindy G Boer; Deborah J Hart; Michelle S Yau; Yolande F M Ramos; Sarah Metrustry; Linda Broer; Joris Deelen; L Adrienne Cupples; Fernando Rivadeneira; Margreet Kloppenburg; Marjolein Peters; Tim D Spector; Albert Hofman; P Eline Slagboom; Rob G H H Nelissen; André G Uitterlinden; David T Felson; Ana M Valdes; Ingrid Meulenbelt; Joyce J B van Meurs Journal: Ann Rheum Dis Date: 2017-08-30 Impact factor: 19.103
Authors: Genevieve Housman; Lorena M Havill; Ellen E Quillen; Anthony G Comuzzie; Anne C Stone Journal: Cartilage Date: 2018-02-19 Impact factor: 4.634
Authors: E Ntoumou; M Tzetis; M Braoudaki; G Lambrou; M Poulou; K Malizos; N Stefanou; L Anastasopoulou; A Tsezou Journal: Clin Epigenetics Date: 2017-12-12 Impact factor: 6.551
Authors: Terence D Capellini; Hao Chen; Jiaxue Cao; Andrew C Doxey; Ata M Kiapour; Michael Schoor; David M Kingsley Journal: Nat Genet Date: 2017-07-03 Impact factor: 38.330
Authors: Jan Neumann; Alan L Zhang; Benedikt J Schwaiger; Michael A Samaan; Richard Souza; Sarah C Foreman; Gabby B Joseph; Trevor Grace; Sharmila Majumdar; Thomas M Link Journal: Eur Radiol Date: 2018-07-09 Impact factor: 5.315