Literature DB >> 28988624

Recently reported biological activities of pyrazole compounds.

Jéssica Venância Faria1, Percilene Fazolin Vegi2, Ana Gabriella Carvalho Miguita3, Maurício Silva Dos Santos4, Nubia Boechat5, Alice Maria Rolim Bernardino2.   

Abstract

The pyrazole nucleus is an aromatic azole heterocycle with two adjacent nitrogen atoms. Pyrazole derivatives have exhibited a broad spectrum of biological activities, and approved pyrazole-containing drugs include celecoxib, antipyrine, phenylbutazone, rimonabant, and dipyrone. Many research groups have synthesized and evaluated pyrazoles against several biological agents. This review examines recent publications relating the structures of pyrazoles with their corresponding biological activities.
Copyright © 2017 Elsevier Ltd. All rights reserved.

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Year:  2017        PMID： 28988624     DOI： 10.1016/j.bmc.2017.09.035

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  29 in total

1.  Synthesis of Spirobicyclic Pyrazoles by Intramolecular Dipolar Cycloadditions/[1s, 5s] Sigmatropic Rearrangements.

Authors:  Christine A Dimirjian; Marta Castiñeira Reis; Edward I Balmond; Nolan C Turman; Elys P Rodriguez; Michael J Di Maso; James C Fettinger; Dean J Tantillo; Jared T Shaw
Journal:  Org Lett       Date:  2019-09-05       Impact factor: 6.005

2.  Solvent-free synthesis of isoindolo[2,1-c]pyrazolo[1,5-a]quinazoline and pyrazolo[5',1':2,3]pyrimido[6,1-a]isoindol derivatives through a one-pot three-component reaction.

Authors:  Meysam Alizadeh-Kouzehrash; Abbas Rahmati
Journal:  Mol Divers       Date:  2020-02-19       Impact factor: 2.943

Review 3.  Evaluation of Substituted Pyrazole-Based Kinase Inhibitors in One Decade (2011-2020): Current Status and Future Prospects.

Authors:  Mohammed I El-Gamal; Seyed-Omar Zaraei; Moustafa M Madkour; Hanan S Anbar
Journal:  Molecules       Date:  2022-01-05       Impact factor: 4.411

4.  Xanthohumol Pyrazole Derivative Improves Diet-Induced Obesity and Induces Energy Expenditure in High-Fat Diet-Fed Mice.

Authors:  Ines L Paraiso; Luce M Mattio; Armando Alcázar Magaña; Jaewoo Choi; Layhna S Plagmann; Margaret A Redick; Cristobal L Miranda; Claudia S Maier; Sabrina Dallavalle; Chrissa Kioussi; Paul R Blakemore; Jan F Stevens
Journal:  ACS Pharmacol Transl Sci       Date:  2021-11-04

5.  Synthesis and antimicrobial studies of hydrazone derivatives of 4-[3-(2,4-difluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic acid and 4-[3-(3,4-difluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic acid.

Authors:  A A Zakeyah; J Whitt; C Duke; D F Gilmore; D G Meeker; M S Smeltzer; M A Alam
Journal:  Bioorg Med Chem Lett       Date:  2018-07-10       Impact factor: 2.823

6.  Regioselective Synthesis of Functionalized 3- or 5-Fluoroalkyl Isoxazoles and Pyrazoles from Fluoroalkyl Ynones and Binucleophiles.

Authors:  Bohdan A Chalyk; Andrii Khutorianskyi; Andrii Lysenko; Yulia Fil; Yuliya O Kuchkovska; Konstantin S Gavrilenko; Iulia Bakanovych; Yurii S Moroz; Alina O Gorlova; Oleksandr O Grygorenko
Journal:  J Org Chem       Date:  2019-11-08       Impact factor: 4.354

7.  Heterogeneous Co-catalyzed direct 2-alkylation of azoles with ethers.

Authors:  Ke Yang; Dashan Li; Lei Zhang; Qun Chen; Tiandi Tang
Journal:  RSC Adv       Date:  2018-04-12       Impact factor: 3.361

8.  Synthesis and Biological Evaluations of Monocarbonyl Curcumin Inspired Pyrazole Analogues as Potential Anti-Colon Cancer Agent.

Authors:  Zhenli Min; Yue Zhu; Xing Hong; Zhijun Yu; Min Ye; Qiong Yuan; Xiamin Hu
Journal:  Drug Des Devel Ther       Date:  2020-06-29       Impact factor: 4.162

Review 9.  Heterocyclic Compounds: Pharmacology of Pyrazole Analogs From Rational Structural Considerations.

Authors:  Rafael Fernades Costa; Larissa Córdova Turones; Keilah Valéria Naves Cavalcante; Ismael Aureliano Rosa Júnior; Carlos Henrique Xavier; Lucimar Pinheiro Rosseto; Hamilton Barbosa Napolitano; Patrícia Ferreira da Silva Castro; Marcos Luiz Ferreira Neto; Gustavo Mota Galvão; Ricardo Menegatti; Gustavo Rodrigues Pedrino; Elson Alves Costa; José Luis Rodrigues Martins; James Oluwagbamigbe Fajemiroye
Journal:  Front Pharmacol       Date:  2021-05-10       Impact factor: 5.810

10.  A novel series of pyrazole-platinum(II) complexes as potential anti-cancer agents that induce cell cycle arrest and apoptosis in breast cancer cells.

Authors:  Robert Czarnomysy; Arkadiusz Surażyński; Anna Muszynska; Agnieszka Gornowicz; Anna Bielawska; Krzysztof Bielawski
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051
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