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Literature DB >> 2898784

Identification of carbohydrate structures that are possible receptors for Neisseria gonorrhoeae.

N Stromberg¹, C Deal, G Nyberg, S Normark, M So, K A Karlsson.

Abstract

Different strains and isogenic variants of Neisseria gonorrhoeae were assayed for their ability to bind glycolipids extracted from various sources. Among a large number of reference glycolipids, binding was observed only to lactosylceramide [Gal(beta 1-4)Glc(beta 1-1)Cer], isoglobotriaosylceramide [Gal(alpha 1-3)Gal(beta 1-4)Glc(beta 1-1)Cer], gangliotriaosylceramide [GalNAc(beta 1-4)Gal(beta 1-4)Glc(beta 1-1)Cer], and gangliotetraosylceramide [Gal(beta 1-3)GalNAc(beta 1-4)Gal(beta 1-4)Glc(beta 1-1)Cer]. The latter two glycolipids bound gonococci with the highest affinity. Lactosylceramide and gangliotriaosylceramide were found in glycolipid preparations from ME180 cells, an epithelial cell line derived from a human cervical carcinoma, and thus are possible receptors for gonococci. The gonococcal surface component that bound the above glycolipids is a protein distinct from pilin and protein II.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1988 PMID： 2898784 PMCID： PMC280545 DOI： 10.1073/pnas.85.13.4902

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

23 in total

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Journal: J Natl Cancer Inst Date: 1970-07 Impact factor: 13.506

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Journal: Biochim Biophys Acta Date: 1983-01-07

4. Gangliotetraosylceramide is a major glycolipid of epithelial cells of mouse small intestine.

Authors: G C Hansson; K A Karlsson; H Leffler; N Strömberg
Journal: FEBS Lett Date: 1982-03-22 Impact factor: 4.124

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Authors: E R Gubish; K C Chen; T M Buchanan
Journal: Infect Immun Date: 1982-07 Impact factor: 3.441

6. Lewis blood group fucolipids and their isomers from human and canine intestine.

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Journal: J Biol Chem Date: 1982-01-25 Impact factor: 5.157

7. Glycosphingolipids of a green monkey kidney cell line (GMK AH-1). Evidence for a novel pentaglycosylceramide based on globotetraosylceramide.

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Journal: Biochim Biophys Acta Date: 1982-06-11

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Authors: R Skarjune; E Oldfield
Journal: Biochemistry Date: 1982-06-22 Impact factor: 3.162

9. An antigen present in rat adenocarcinoma and normal colon non-epithelial stroma is a novel Forssman-like glycolipid based on isoglobotetraosylceramide.

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Journal: Biochim Biophys Acta Date: 1986-09-12

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Journal: J Biol Chem Date: 1979-09-25 Impact factor: 5.157

28 in total

Review 1. Genetic mechanisms and biological implications of phase variation in pathogenic neisseriae.

Authors: T F Meyer; J P van Putten
Journal: Clin Microbiol Rev Date: 1989-04 Impact factor: 26.132

Review 2. Gonococcal vaccines.

Authors: E C Tramont
Journal: Clin Microbiol Rev Date: 1989-04 Impact factor: 26.132

3. Interactions of Neisseria gonorrhoeae with human neutrophils: studies with purified PII (Opa) outer membrane proteins and synthetic Opa peptides.

Authors: F L Naids; B Belisle; N Lee; R F Rest
Journal: Infect Immun Date: 1991-12 Impact factor: 3.441

4. Antimicrobial interference with bacterial mechanisms of pathogenicity: effect of sub-MIC azithromycin on gonococcal piliation and attachment to human epithelial cells.

Authors: G L Gorby; Z A McGee
Journal: Antimicrob Agents Chemother Date: 1990-12 Impact factor: 5.191

Review 5. Common themes in microbial pathogenicity.

Authors: B B Finlay; S Falkow
Journal: Microbiol Rev Date: 1989-06

6. Cryptococcus neoformans, Candida albicans, and other fungi bind specifically to the glycosphingolipid lactosylceramide (Gal beta 1-4Glc beta 1-1Cer), a possible adhesion receptor for yeasts.

Authors: V Jimenez-Lucho; V Ginsburg; H C Krivan
Journal: Infect Immun Date: 1990-07 Impact factor: 3.441