Literature DB >> 1982402

Antimicrobial interference with bacterial mechanisms of pathogenicity: effect of sub-MIC azithromycin on gonococcal piliation and attachment to human epithelial cells.

G L Gorby1, Z A McGee.   

Abstract

The effects of subinhibitory concentrations of azithromycin (CP-62,993) on the piliation and attachment properties of Neisseria gonorrhoeae were examined. Subinhibitory concentrations of azithromycin significantly reduced the percentage of gonococci that expressed assembled pili on their surfaces by decreasing pilin subunit synthesis and substantially decreased gonococcal adherence to human mucosal cells.

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Year:  1990        PMID： 1982402      PMCID： PMC172082          DOI： 10.1128/AAC.34.12.2445

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

1.  Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors:  H Towbin; T Staehelin; J Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

2.  Pilus genes of Neisseria gonorrheae: chromosomal organization and DNA sequence.

Authors:  T F Meyer; E Billyard; R Haas; S Storzbach; M So
Journal:  Proc Natl Acad Sci U S A       Date:  1984-10       Impact factor: 11.205

3.  Ultrastructural localization of specific gonococcal macromolecules with antibody-gold sphere immunological probes.

Authors:  E N Robinson; Z A McGee; J Kaplan; M E Hammond; J K Larson; T M Buchanan; G K Schoolnik
Journal:  Infect Immun       Date:  1984-11       Impact factor: 3.441

4.  Loss of pili and decreased attachment to human cells by Neisseria meningitidis and Neisseria gonorrhoeae exposed to subinhibitory concentrations of antibiotics.

Authors:  D S Stephens; J W Krebs; Z A McGee
Journal:  Infect Immun       Date:  1984-11       Impact factor: 3.441

5.  Biological properties of two distinct pilus types produced by isogenic variants of Neisseria gonorrhoeae P9.

Authors:  P R Lambden; J N Robertson; P J Watt
Journal:  J Bacteriol       Date:  1980-01       Impact factor: 3.490

6.  Interactions of gonococci with HeLa cells: attachment, detachment, replication, penetration, and the role of protein II.

Authors:  D Bessen; E C Gotschlich
Journal:  Infect Immun       Date:  1986-10       Impact factor: 3.441

7.  Effect of antibiotics on production of enzymes and toxins by microorganisms.

Authors:  A M Shibl
Journal:  Rev Infect Dis       Date:  1983 Sep-Oct

8.  A rapid, sensitive method for detection of alkaline phosphatase-conjugated anti-antibody on Western blots.

Authors:  M S Blake; K H Johnston; G J Russell-Jones; E C Gotschlich
Journal:  Anal Biochem       Date:  1984-01       Impact factor: 3.365

9.  Attachment of Neisseria meningitidis to human mucosal surfaces: influence of pili and type of receptor cell.

Authors:  D S Stephens; Z A McGee
Journal:  J Infect Dis       Date:  1981-04       Impact factor: 5.226

10.  Surface-exposed protein antigens of the gonococcal outer membrane.

Authors:  J Swanson
Journal:  Infect Immun       Date:  1981-12       Impact factor: 3.441
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  6 in total

1.  Blood, tissue, and intracellular concentrations of azithromycin during and after end of therapy.

Authors:  P Matzneller; S Krasniqi; M Kinzig; F Sörgel; S Hüttner; E Lackner; M Müller; M Zeitlinger
Journal:  Antimicrob Agents Chemother       Date:  2013-01-28       Impact factor: 5.191

2.  Effects of sub-MICs of erythromycin and other macrolide antibiotics on serum sensitivity of Pseudomonas aeruginosa.

Authors:  K Tateda; Y Hirakata; N Furuya; A Ohno; K Yamaguchi
Journal:  Antimicrob Agents Chemother       Date:  1993-04       Impact factor: 5.191

3.  Sub-Inhibitory Concentration of Piperacillin-Tazobactam May be Related to Virulence Properties of Filamentous Escherichia coli.

Authors:  João Paulo Lopes de Andrade; Luiz de Macêdo Farias; João Fernando Gonçalves Ferreira; Oscar Bruna-Romero; Daniele da Glória de Souza; Maria Auxiliadora Roque de Carvalho; Kênia Valéria dos Santos
Journal:  Curr Microbiol       Date:  2015-09-12       Impact factor: 2.188

4.  Effects of subinhibitory concentrations of antibiotics on biological properties of Salmonella typhimurium.

Authors:  L Majtánová; A Hostacká; V Majtán
Journal:  Folia Microbiol (Praha)       Date:  1994       Impact factor: 2.099

5.  Subinhibitory Concentrations of Trimethoprim and Sulfamethoxazole Prevent Biofilm Formation by Acinetobacter baumannii through Inhibition of Csu Pilus Expression.

Authors:  Ki Hwan Moon; Brent S Weber; Mario F Feldman
Journal:  Antimicrob Agents Chemother       Date:  2017-08-24       Impact factor: 5.191

6.  External Stresses Affect Gonococcal Type 4 Pilus Dynamics.

Authors:  Sebastian Kraus-Römer; Isabelle Wielert; Isabel Rathmann; Jan Grossbach; Berenike Maier
Journal:  Front Microbiol       Date:  2022-02-25       Impact factor: 5.640
  6 in total

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