K Paapstel1, J Kals2, J Eha3, K Tootsi4, A Ottas5, A Piir5, M Jakobson6, J Lieberg7, M Zilmer8. 1. Institute of Biomedicine and Translational Medicine, Department of Biochemistry, Centre of Excellence for Genomics and Translational Medicine, University of Tartu, 19 Ravila Street, Tartu 50411, Estonia; Endothelial Centre, University of Tartu, 8 Puusepa Street, Tartu 51014, Estonia. Electronic address: paapstel@outlook.com. 2. Institute of Biomedicine and Translational Medicine, Department of Biochemistry, Centre of Excellence for Genomics and Translational Medicine, University of Tartu, 19 Ravila Street, Tartu 50411, Estonia; Endothelial Centre, University of Tartu, 8 Puusepa Street, Tartu 51014, Estonia; Department of Surgery, University of Tartu, 8 Puusepa Street, Tartu 51014, Estonia. 3. Endothelial Centre, University of Tartu, 8 Puusepa Street, Tartu 51014, Estonia; Department of Cardiology, University of Tartu, 8 Puusepa Street, Tartu 51014, Estonia. 4. Endothelial Centre, University of Tartu, 8 Puusepa Street, Tartu 51014, Estonia. 5. Institute of Biomedicine and Translational Medicine, Department of Biochemistry, Centre of Excellence for Genomics and Translational Medicine, University of Tartu, 19 Ravila Street, Tartu 50411, Estonia. 6. Department of Radiology, Tartu University Hospital, Tartu 51014, Estonia. 7. Department of Surgery, University of Tartu, 8 Puusepa Street, Tartu 51014, Estonia. 8. Institute of Biomedicine and Translational Medicine, Department of Biochemistry, Centre of Excellence for Genomics and Translational Medicine, University of Tartu, 19 Ravila Street, Tartu 50411, Estonia; Endothelial Centre, University of Tartu, 8 Puusepa Street, Tartu 51014, Estonia.
Abstract
BACKGROUND AND AIMS: The rapidly growing discipline of lipidomics allows the study of a wide spectrum of lipid species in body fluids and provides new insights into the pathogenesis of cardiovascular disease. We investigated serum phosphatidylcholine (PC) and lysophosphatidylcholine (lysoPC) species in relation to arterial stiffness, hemodynamics, and endothelial dysfunction in symptomatic patients with atherosclerosis and in healthy controls. METHODS AND RESULTS: Thirty-two patients with peripheral arterial disease (age 61.7 ± 9.0 years), 52 patients with coronary artery disease (age 63.2 ± 9.2 years), and 40 apparently healthy controls (age 60.3 ± 7.1 years) were studied. Serum levels of 90 glycerophospholipids were determined with the AbsoluteIDQ™ p180 kit (BIOCRATES Life Sciences AG, Innsbruck, Austria). The technique of applanation tonometry was used for non-invasive pulse wave analysis and carotid-femoral pulse wave velocity (cf-PWV) assessment. Decreased serum levels of several individual PC and lysoPC species (e.g., PC aa C28:1, PC aa C30:0, PC aa C32:2, PC ae C30:0 and PC ae C34:2, lysoPC a C18:2) were observed for the patient groups in comparison to the healthy subjects. In addition, a considerable number of PCs and lysoPCs were inversely related to either cf-PWV, heart rate, asymmetric dimethylarginine (ADMA) or ADMA/arginine for patients with symptomatic atherosclerosis but not for the controls. CONCLUSION: We found altered relationships between PC and lysoPC profiles, inflammation, and arterial function in atherosclerotic patients, compared to healthy subjects.
BACKGROUND AND AIMS: The rapidly growing discipline of lipidomics allows the study of a wide spectrum of lipid species in body fluids and provides new insights into the pathogenesis of cardiovascular disease. We investigated serum phosphatidylcholine (PC) and lysophosphatidylcholine (lysoPC) species in relation to arterial stiffness, hemodynamics, and endothelial dysfunction in symptomatic patients with atherosclerosis and in healthy controls. METHODS AND RESULTS: Thirty-two patients with peripheral arterial disease (age 61.7 ± 9.0 years), 52 patients with coronary artery disease (age 63.2 ± 9.2 years), and 40 apparently healthy controls (age 60.3 ± 7.1 years) were studied. Serum levels of 90 glycerophospholipids were determined with the AbsoluteIDQ™ p180 kit (BIOCRATES Life Sciences AG, Innsbruck, Austria). The technique of applanation tonometry was used for non-invasive pulse wave analysis and carotid-femoral pulse wave velocity (cf-PWV) assessment. Decreased serum levels of several individual PC and lysoPC species (e.g., PC aa C28:1, PC aa C30:0, PC aa C32:2, PC ae C30:0 and PC ae C34:2, lysoPC a C18:2) were observed for the patient groups in comparison to the healthy subjects. In addition, a considerable number of PCs and lysoPCs were inversely related to either cf-PWV, heart rate, asymmetric dimethylarginine (ADMA) or ADMA/arginine for patients with symptomatic atherosclerosis but not for the controls. CONCLUSION: We found altered relationships between PC and lysoPC profiles, inflammation, and arterial function in atheroscleroticpatients, compared to healthy subjects.
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