Fatimah Haruna1, Andrea Lipsett1, Laure Marignol2. 1. Applied Radiation Therapy Trinity (ARTT), Discipline of Radiation Therapy, School of Medicine, Trinity College Dublin, Dublin, Ireland. 2. Applied Radiation Therapy Trinity (ARTT), Discipline of Radiation Therapy, School of Medicine, Trinity College Dublin, Dublin, Ireland marignol@tcd.ie.
Abstract
AIM: To evaluate the efficacy of topical corticosteroids in managing acute radiation dermatitis (RD) in female breast cancer patients. MATERIALS AND METHODS: MEDLINE, EMBASE, CINAHL, CENTRAL, ScienceDirect, Google Scholar and Clinicaltrials.gov were searched up to and including March 2017 to identify Randomised Controlled Trials (RCTs) assessing topical corticosteroids for the management and prevention of acute RD. RESULTS: Ten RCTs (919 participants) were identified. Meta-analysis, including results for 845 participants, demonstrated significant benefits of topical corticosteroids in preventing the incidence of wet desquamation (OR: 0.29; 95%CI: 0.19-0.45; p<0.0001) and reducing the mean RD score (SMD: -0.47, 95%CI: -0.61 - -0.33, p<0.00001). CONCLUSION: Topical corticosteroids impacted on the incidence of wet desquamation and the average RD score observed in female breast cancer patients. The use of topical corticosteroids can reduce pruritus in participants and improve quality of life. Copyright
AIM: To evaluate the efficacy of topical corticosteroids in managing acute radiation dermatitis (RD) in female breast cancerpatients. MATERIALS AND METHODS: MEDLINE, EMBASE, CINAHL, CENTRAL, ScienceDirect, Google Scholar and Clinicaltrials.gov were searched up to and including March 2017 to identify Randomised Controlled Trials (RCTs) assessing topical corticosteroids for the management and prevention of acute RD. RESULTS: Ten RCTs (919 participants) were identified. Meta-analysis, including results for 845 participants, demonstrated significant benefits of topical corticosteroids in preventing the incidence of wet desquamation (OR: 0.29; 95%CI: 0.19-0.45; p<0.0001) and reducing the mean RD score (SMD: -0.47, 95%CI: -0.61 - -0.33, p<0.00001). CONCLUSION: Topical corticosteroids impacted on the incidence of wet desquamation and the average RD score observed in female breast cancerpatients. The use of topical corticosteroids can reduce pruritus in participants and improve quality of life. Copyright
Authors: Songmi Ahn; Kihoon Sung; Hyun Ju Kim; Young Eun Choi; Young Kyu Lee; Jeong Soo Kim; Seul Ki Lee; Joo-Young Roh Journal: In Vivo Date: 2020 Jan-Feb Impact factor: 2.155
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