| Literature DB >> 28982794 |
Kay Prüfer1, Cesare de Filippo2, Steffi Grote2, Fabrizio Mafessoni2, Petra Korlević2, Mateja Hajdinjak2, Benjamin Vernot2, Laurits Skov3, Pinghsun Hsieh4, Stéphane Peyrégne2, David Reher2, Charlotte Hopfe2, Sarah Nagel2, Tomislav Maricic2, Qiaomei Fu5, Christoph Theunert2,6, Rebekah Rogers6, Pontus Skoglund7, Manjusha Chintalapati2, Michael Dannemann2, Bradley J Nelson4, Felix M Key2, Pavao Rudan8, Željko Kućan8, Ivan Gušić8, Liubov V Golovanova9, Vladimir B Doronichev9, Nick Patterson7, David Reich7,10,11, Evan E Eichler4,12, Montgomery Slatkin6, Mikkel H Schierup3, Aida M Andrés2, Janet Kelso2, Matthias Meyer2, Svante Pääbo1.
Abstract
To date, the only Neandertal genome that has been sequenced to high quality is from an individual found in Southern Siberia. We sequenced the genome of a female Neandertal from ~50,000 years ago from Vindija Cave, Croatia, to ~30-fold genomic coverage. She carried 1.6 differences per 10,000 base pairs between the two copies of her genome, fewer than present-day humans, suggesting that Neandertal populations were of small size. Our analyses indicate that she was more closely related to the Neandertals that mixed with the ancestors of present-day humans living outside of sub-Saharan Africa than the previously sequenced Neandertal from Siberia, allowing 10 to 20% more Neandertal DNA to be identified in present-day humans, including variants involved in low-density lipoprotein cholesterol concentrations, schizophrenia, and other diseases.Entities:
Mesh：
Substances：
Year: 2017 PMID： 28982794 PMCID： PMC6185897 DOI： 10.1126/science.aao1887
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728