Literature DB >> 28980882

Super enhancers - new analyses and perspectives on the low hanging fruit.

Feda H Hamdan1, Steven A Johnsen1.   

Abstract

Significant attention has recently been given to a class of enhancers termed "super enhancers", while implying that "typical enhancers" are less important. In this report, we examine criteria for identification of super enhancers and address the need to evaluate the differences between BRD4-occupied "typical" and "super" enhancers.

Entities:  

Keywords:  BRD4; ERα activation; ROSE algorithm; enhancer RNA; super enhancers; transcriptional regulation; typical enhancers

Mesh：

Substances：

Year:  2017        PMID： 28980882      PMCID： PMC5834217          DOI： 10.1080/21541264.2017.1372044

Source DB:  PubMed          Journal:  Transcription        ISSN： 2154-1272


  29 in total

1.  What are super-enhancers?

Authors:  Sebastian Pott; Jason D Lieb
Journal:  Nat Genet       Date:  2015-01       Impact factor: 38.330

2.  Master transcription factors and mediator establish super-enhancers at key cell identity genes.

Authors:  Warren A Whyte; David A Orlando; Denes Hnisz; Brian J Abraham; Charles Y Lin; Michael H Kagey; Peter B Rahl; Tong Ihn Lee; Richard A Young
Journal:  Cell       Date:  2013-04-11       Impact factor: 41.582

3.  Selective inhibition of tumor oncogenes by disruption of super-enhancers.

Authors:  Jakob Lovén; Heather A Hoke; Charles Y Lin; Ashley Lau; David A Orlando; Christopher R Vakoc; James E Bradner; Tong Ihn Lee; Richard A Young
Journal:  Cell       Date:  2013-04-11       Impact factor: 41.582

Review 4.  Bromodomains: Structure, function and pharmacology of inhibition.

Authors:  Elena Ferri; Carlo Petosa; Charles E McKenna
Journal:  Biochem Pharmacol       Date:  2015-12-18       Impact factor: 5.858

5.  Differential DNase I hypersensitivity reveals factor-dependent chromatin dynamics.

Authors:  Housheng Hansen He; Clifford A Meyer; Mei Wei Chen; V Craig Jordan; Myles Brown; X Shirley Liu
Journal:  Genome Res       Date:  2012-04-16       Impact factor: 9.043

6.  Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth.

Authors:  Kashyap Dave; Inderpreet Sur; Jian Yan; Jilin Zhang; Eevi Kaasinen; Fan Zhong; Leander Blaas; Xiaoze Li; Shabnam Kharazi; Charlotte Gustafsson; Ayla De Paepe; Robert Månsson; Jussi Taipale
Journal:  Elife       Date:  2017-06-06       Impact factor: 8.140

7.  Single-cell profiling reveals that eRNA accumulation at enhancer-promoter loops is not required to sustain transcription.

Authors:  Samir Rahman; Cornelia E Zorca; Tatiana Traboulsi; Emmanuel Noutahi; Matthew R Krause; Sylvie Mader; Daniel Zenklusen
Journal:  Nucleic Acids Res       Date:  2017-04-07       Impact factor: 16.971

8.  GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility.

Authors:  Vasiliki Theodorou; Rory Stark; Suraj Menon; Jason S Carroll
Journal:  Genome Res       Date:  2012-11-21       Impact factor: 9.043

9.  Bromodomain protein BRD4 is required for estrogen receptor-dependent enhancer activation and gene transcription.

Authors:  Sankari Nagarajan; Tareq Hossan; Malik Alawi; Zeynab Najafova; Daniela Indenbirken; Upasana Bedi; Hanna Taipaleenmäki; Isabel Ben-Batalla; Marina Scheller; Sonja Loges; Stefan Knapp; Eric Hesse; Cheng-Ming Chiang; Adam Grundhoff; Steven A Johnsen
Journal:  Cell Rep       Date:  2014-07-10       Impact factor: 9.423

10.  Hierarchy within the mammary STAT5-driven Wap super-enhancer.

Authors:  Ha Youn Shin; Michaela Willi; Kyung HyunYoo; Xianke Zeng; Chaochen Wang; Gil Metser; Lothar Hennighausen
Journal:  Nat Genet       Date:  2016-07-04       Impact factor: 38.330
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  5 in total

1.  DeltaNp63-dependent super enhancers define molecular identity in pancreatic cancer by an interconnected transcription factor network.

Authors:  Feda H Hamdan; Steven A Johnsen
Journal:  Proc Natl Acad Sci U S A       Date:  2018-12-12       Impact factor: 11.205

2.  PHF13 epigenetically activates TGFβ driven epithelial to mesenchymal transition.

Authors:  Yating Sun; Dan Li; Hongmei Liu; Yongye Huang; Fanyu Meng; Jiahao Tang; Zhanjun Li; Wanhua Xie
Journal:  Cell Death Dis       Date:  2022-05-21       Impact factor: 9.685

Review 3.  Dysregulated Transcriptional Control in Prostate Cancer.

Authors:  Simon J Baumgart; Ekaterina Nevedomskaya; Bernard Haendler
Journal:  Int J Mol Sci       Date:  2019-06-13       Impact factor: 5.923

4.  Darolutamide antagonizes androgen signaling by blocking enhancer and super-enhancer activation.

Authors:  Simon J Baumgart; Ekaterina Nevedomskaya; Ralf Lesche; Richard Newman; Dominik Mumberg; Bernard Haendler
Journal:  Mol Oncol       Date:  2020-06-05       Impact factor: 6.603

5.  Super enhancer regulation of cytokine-induced chemokine production in alcoholic hepatitis.

Authors:  Mengfei Liu; Sheng Cao; Li He; Jinhang Gao; Juan P Arab; Huarui Cui; Weixia Xuan; Yandong Gao; Tejasav S Sehrawat; Feda H Hamdan; Meritxell Ventura-Cots; Josepmaria Argemi; William C K Pomerantz; Steven A Johnsen; Jeong-Heon Lee; Fei Gao; Tamas Ordog; Philippe Mathurin; Alexander Revzin; Ramon Bataller; Huihuang Yan; Vijay H Shah
Journal:  Nat Commun       Date:  2021-07-27       Impact factor: 14.919
  5 in total

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