| Literature DB >> 28979828 |
Maria Giovanna Francipane1,2, Eric Lagasse1.
Abstract
In recent years, functional three-dimensional (3D) tissue generation in vitro has been significantly advanced by tissue-engineering methods, achieving better reproduction of complex native organs compared to conventional culture systems. This review will discuss traditional 3D cell culture techniques as well as newly developed technology platforms. These recent techniques provide new possibilities in the creation of human body parts and provide more accurate predictions of tissue response to drug and chemical challenges. Given the rapid advancement in the human induced pluripotent stem cell (iPSC) field, these platforms also hold great promise in the development of patient-specific, transplantable tissues and organs on demand.Entities:
Keywords: 3D bioprinting; blastocyst complementation; miniature organs; organoids; organs-on-chips; spheroids
Year: 2016 PMID： 28979828 PMCID： PMC5624548 DOI： 10.1007/s40139-016-0111-9
Source DB: PubMed Journal: Curr Pathobiol Rep ISSN： 2167-485X