Gisele Trennepohl da Costa Heinen1, Daniella Schmit1, Denise Johnsson Campos1, Carmem Bonfim2, Estela Iraci Rabito3, Regina Maria Vilela4. 1. Clinics Hospital, Federal University of Paraná (HC/UFPR), Curitiba, Brazil. 2. Federal University of Paraná (HC/UFPR), Curitiba, Brazil. 3. Department of Nutrition, Federal University of Paraná-UFPR, 632, Prefeito Lothário Meissner Avenue, Jardim Botânico, Curitiba, Paraná, 80210-170, Brazil. 4. Department of Nutrition, Federal University of Paraná-UFPR, 632, Prefeito Lothário Meissner Avenue, Jardim Botânico, Curitiba, Paraná, 80210-170, Brazil. regina.vilela@mail.mcgill.ca.
Abstract
OBJECTIVE: The objective of this study was to evaluate the nutritional status of children diagnosed with Fanconi anemia (FA) during hematopoietic stem cell transplant (HSCT), comparing it with healthy children and children with other hematologic diseases. METHODS: Observational retrospective study was conducted with patients submitted to HSCT in a period of 5 years. We assessed anthropometric and biochemical data, food intake, and gastrointestinal complications in 49 FA patients. We compared the anthropometric information with those of transplanted patients with other diagnoses (n = 54) in three periods (pre-transplant, 15 and 30 days after the HSCT), and with a group of healthy children (n = 24). RESULTS: Throughout the post-HSCT period, there was a significant decline in the nutritional status of FA patients: 83.3% presented weight loss equal to or greater than 5%. A progressive decrease in food intake after the transplantation was observed, with weekly deficits reaching 7841.3 kcal and 347.6 g of protein (both p < 0.05). When comparing FA with other diagnoses patients, the former displayed a poorer nutritional status prior to HSCT (p < 0.01 for BMI/age z-score), and that difference was maintained during the transplant (p < 0.01 for the same parameter), with similar weight loss values for both groups (8.99 vs 7.91%, respectively; p > 0.05). When compared to the control group of healthy children, FA patients prior HSCT showed substantially lower z-scores for Ht./age (p < 0.01) and BMI/age (p < 0.05). CONCLUSION: Although FA patients demonstrated poorer nutritional status as compared to other diagnosis and healthy children, the decline of anthropometric measures along the treatment is similar to other transplanted patients, imposing a greater risk to FA patients.
OBJECTIVE: The objective of this study was to evaluate the nutritional status of children diagnosed with Fanconi anemia (FA) during hematopoietic stem cell transplant (HSCT), comparing it with healthy children and children with other hematologic diseases. METHODS: Observational retrospective study was conducted with patients submitted to HSCT in a period of 5 years. We assessed anthropometric and biochemical data, food intake, and gastrointestinal complications in 49 FA patients. We compared the anthropometric information with those of transplanted patients with other diagnoses (n = 54) in three periods (pre-transplant, 15 and 30 days after the HSCT), and with a group of healthy children (n = 24). RESULTS: Throughout the post-HSCT period, there was a significant decline in the nutritional status of FA patients: 83.3% presented weight loss equal to or greater than 5%. A progressive decrease in food intake after the transplantation was observed, with weekly deficits reaching 7841.3 kcal and 347.6 g of protein (both p < 0.05). When comparing FA with other diagnoses patients, the former displayed a poorer nutritional status prior to HSCT (p < 0.01 for BMI/age z-score), and that difference was maintained during the transplant (p < 0.01 for the same parameter), with similar weight loss values for both groups (8.99 vs 7.91%, respectively; p > 0.05). When compared to the control group of healthy children, FA patients prior HSCT showed substantially lower z-scores for Ht./age (p < 0.01) and BMI/age (p < 0.05). CONCLUSION: Although FA patients demonstrated poorer nutritional status as compared to other diagnosis and healthy children, the decline of anthropometric measures along the treatment is similar to other transplanted patients, imposing a greater risk to FA patients.
Authors: Anna Petryk; Lynda E Polgreen; Jessie L Barnum; Lei Zhang; James S Hodges; K Scott Baker; John E Wagner; Julia Steinberger; Margaret L MacMillan Journal: Biol Blood Marrow Transplant Date: 2015-01-13 Impact factor: 5.742
Authors: Ruth Williams-Hooker; Marissa Adams; David A Havrilla; Wing Leung; Robin R Roach; Terezie T Mosby Journal: Pediatr Blood Cancer Date: 2015-03-21 Impact factor: 3.167
Authors: M H Seltzer; J A Bastidas; D M Cooper; P Engler; B Slocum; H S Fletcher Journal: JPEN J Parenter Enteral Nutr Date: 1979 May-Jun Impact factor: 4.016
Authors: Lori J Bechard; Eva C Guinan; Henry A Feldman; Vivian Tang; Christopher Duggan Journal: JPEN J Parenter Enteral Nutr Date: 2007 Jul-Aug Impact factor: 4.016
Authors: Erika Elias Ferreira; Daiane Cristina Guerra; Kátia Baluz; Wander de Resende Furtado; Luis Fernando da Silva Bouzas Journal: Rev Bras Hematol Hemoter Date: 2014-07-18