Zheng Jiang1,2, Yi Tang3, Lichuan Yang3, Xuhua Mi3, Wei Qin4. 1. Division of Nephrology, Department of Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China. 2. West China School of Medicine, Sichuan University, Chengdu, Sichuan, China. 3. Division of Nephrology, Department of Medicine, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. 4. Division of Nephrology, Department of Medicine, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. ddqstrike@163.com.
Abstract
AIM: To evaluate the efficacy and safety of the restricted protein diet supplemented with keto analogues when applied in end-stage renal disease (ESRD). METHODS: The Cochrane Library, PubMed, Embase, CBM and CENTRAL databases were searched and reviewed up to January 2017. Clinical trials were analyzed using RevMan 5.3 software. RESULTS: Five randomized controlled trials were selected and included in this study according to our inclusion and exclusion criteria. Changes in serum albumin, PTH, triglyceride, cholesterol, calcium, phosphorus, hemoglobin, Kt/v and CRP before and after treatment were analyzed. Meta-analysis results indicated that, compared with normal protein diet, low-protein diet (LPD) supplemented with keto analogues (sLPD) could improve serum albumin (P < 0.00001), hyperparathyroidism (P < 0.00001) and hyperphosphatemia (P = 0.008). No differences in triglyceride, cholesterol, hemoglobin, Kt/v and CRP were observed between different protein intake groups. CONCLUSION: Restricted protein diet supplemented with keto analogues (sLPD) may improve nutritional status and prevent hyperparathyroidism in ESRD patients. The current data were mainly obtained from short-term, single-center trails with small sample sizes and limited nutritional status indexes, indicating a need for further study.
AIM: To evaluate the efficacy and safety of the restricted protein diet supplemented with keto analogues when applied in end-stage renal disease (ESRD). METHODS: The Cochrane Library, PubMed, Embase, CBM and CENTRAL databases were searched and reviewed up to January 2017. Clinical trials were analyzed using RevMan 5.3 software. RESULTS: Five randomized controlled trials were selected and included in this study according to our inclusion and exclusion criteria. Changes in serum albumin, PTH, triglyceride, cholesterol, calcium, phosphorus, hemoglobin, Kt/v and CRP before and after treatment were analyzed. Meta-analysis results indicated that, compared with normal protein diet, low-protein diet (LPD) supplemented with keto analogues (sLPD) could improve serum albumin (P < 0.00001), hyperparathyroidism (P < 0.00001) and hyperphosphatemia (P = 0.008). No differences in triglyceride, cholesterol, hemoglobin, Kt/v and CRP were observed between different protein intake groups. CONCLUSION: Restricted protein diet supplemented with keto analogues (sLPD) may improve nutritional status and prevent hyperparathyroidism in ESRDpatients. The current data were mainly obtained from short-term, single-center trails with small sample sizes and limited nutritional status indexes, indicating a need for further study.
Authors: Rajiv Saran; Yi Li; Bruce Robinson; Kevin C Abbott; Lawrence Y C Agodoa; John Ayanian; Jennifer Bragg-Gresham; Rajesh Balkrishnan; Joline L T Chen; Elizabeth Cope; Paul W Eggers; Daniel Gillen; Debbie Gipson; Susan M Hailpern; Yoshio N Hall; Kevin He; William Herman; Michael Heung; Richard A Hirth; David Hutton; Steven J Jacobsen; Kamyar Kalantar-Zadeh; Csaba P Kovesdy; Yee Lu; Miklos Z Molnar; Hal Morgenstern; Brahmajee Nallamothu; Danh V Nguyen; Ann M O'Hare; Brett Plattner; Ronald Pisoni; Friedrich K Port; Panduranga Rao; Connie M Rhee; Ankit Sakhuja; Douglas E Schaubel; David T Selewski; Vahakn Shahinian; John J Sim; Peter Song; Elani Streja; Manjula Kurella Tamura; Francesca Tentori; Sarah White; Kenneth Woodside; Richard A Hirth Journal: Am J Kidney Dis Date: 2016-03 Impact factor: 8.860