BACKGROUND: Human skin surface has a physiologically acidic pH (pHss). In cases of increased pHss, the acidity of the skin can be restored by topical formulations. We tested a pH 5 oil-in-water (O/W) emulsion for pHss regeneration and stabilization. METHODS: We performed 2 experiments with 10 female study subjects in each. In both experiments, 2D imaging with luminescent sensor foils was used to determine pHss. Alkalization was reached by washing the volar forearm with a soap bar and warm running tap water for 20 min. Experiment 1: after defining the baseline pHss, we alkalized the respective area and measured pHss over a duration of 5 h, while applying emulsion every hour. Experiment 2: study subjects used the emulsion twice daily for 1 week. Then, pHss was measured before and after 5 min of washing a treated and an untreated area on the volar forearm. RESULTS: (1) 5 h after alkalization, the treated arm showed a significantly lower pHss than the untreated one (5.87 ± 0.03 vs. 6.05 ± 0.03); (2) after washing, the treated area had a significantly lower pHss than controls (6.13 ± 0.03 vs. 6.27 ± 0.05). CONCLUSIONS: The tested pH 5 O/W emulsion seems to improve regeneration and stabilization of pHss.
BACKGROUND:Human skin surface has a physiologically acidic pH (pHss). In cases of increased pHss, the acidity of the skin can be restored by topical formulations. We tested a pH 5 oil-in-water (O/W) emulsion for pHss regeneration and stabilization. METHODS: We performed 2 experiments with 10 female study subjects in each. In both experiments, 2D imaging with luminescent sensor foils was used to determine pHss. Alkalization was reached by washing the volar forearm with a soap bar and warm running tap water for 20 min. Experiment 1: after defining the baseline pHss, we alkalized the respective area and measured pHss over a duration of 5 h, while applying emulsion every hour. Experiment 2: study subjects used the emulsion twice daily for 1 week. Then, pHss was measured before and after 5 min of washing a treated and an untreated area on the volar forearm. RESULTS: (1) 5 h after alkalization, the treated arm showed a significantly lower pHss than the untreated one (5.87 ± 0.03 vs. 6.05 ± 0.03); (2) after washing, the treated area had a significantly lower pHss than controls (6.13 ± 0.03 vs. 6.27 ± 0.05). CONCLUSIONS: The tested pH 5 O/W emulsion seems to improve regeneration and stabilization of pHss.
Authors: Sonja Haverkampf; Judith Heider; Katharina T Weiß; Frank Haubner; Tobias Ettl; Julia Schreml; Sarah Hedtrich; Marietta von Süßkind-Schwendi; Mark Berneburg; Sigrid Karrer; Joachim Dissemond; Stephan Schreml Journal: Exp Dermatol Date: 2017-01-09 Impact factor: 3.960
Authors: Steffen Auerswald; Stephan Schreml; Robert Meier; Alexandra Blancke Soares; Maximilian Niyazi; Sebastian Marschner; Claus Belka; Martin Canis; Frank Haubner Journal: Radiat Oncol Date: 2019-11-11 Impact factor: 3.481