OBJECTIVE: Diabetes is known to be associated with increased arterial stiffness. However, the temporal association between increased carotid-femoral pulse wave velocity (c-f PWV) and diabetes is unclear. The aim of this study is to explore the relationship between arterial stiffness, as determined by c-f PWV, and incidence of diabetes. RESEARCH DESIGN AND METHODS: The study population included participants from the Malmö Diet and Cancer cardiovascular cohort, using measurements from the 2007-2012 reexamination as baseline. Arterial stiffness was evaluated by measuring c-f PWV (SphygmoCor). After excluding participants with prevalent diabetes (according to measurements of fasting glucose, oral glucose tolerance tests, and physician's diagnoses), the final study population consisted of 2,450 individuals (mean age = 71.9 ± 5.6 years). Incidence of diabetes was followed by linkage to local and national diabetes registers. Cox proportional hazards regression was used to assess the incidence of diabetes in relation to the tertiles of c-f PWV, adjusted for potential confounders. RESULTS: During a mean follow-up of 4.43 ± 1.40 years, 68 (2.8%) participants developed diabetes. Crude incidence of diabetes (per 1,000 person-years) was 3.5, 5.7, and 9.5, respectively, for subjects in the first, second, and third tertiles of c-f PWV. After adjustment for potential confounders, the hazard ratio of diabetes was 1.00 (reference), 1.83 (95% CI 0.88-3.8), and 3.24 (95% CI 1.51-6.97), respectively, for the tertiles of c-f PWV (P for trend = 0.002). CONCLUSIONS: Increased c-f PWV is associated with increased incidence of diabetes, independent of other risk factors. These results suggest that increased arterial stiffness is an early risk marker for developing diabetes.
OBJECTIVE:Diabetes is known to be associated with increased arterial stiffness. However, the temporal association between increased carotid-femoral pulse wave velocity (c-f PWV) and diabetes is unclear. The aim of this study is to explore the relationship between arterial stiffness, as determined by c-f PWV, and incidence of diabetes. RESEARCH DESIGN AND METHODS: The study population included participants from the Malmö Diet and Cancer cardiovascular cohort, using measurements from the 2007-2012 reexamination as baseline. Arterial stiffness was evaluated by measuring c-f PWV (SphygmoCor). After excluding participants with prevalent diabetes (according to measurements of fasting glucose, oral glucose tolerance tests, and physician's diagnoses), the final study population consisted of 2,450 individuals (mean age = 71.9 ± 5.6 years). Incidence of diabetes was followed by linkage to local and national diabetes registers. Cox proportional hazards regression was used to assess the incidence of diabetes in relation to the tertiles of c-f PWV, adjusted for potential confounders. RESULTS: During a mean follow-up of 4.43 ± 1.40 years, 68 (2.8%) participants developed diabetes. Crude incidence of diabetes (per 1,000 person-years) was 3.5, 5.7, and 9.5, respectively, for subjects in the first, second, and third tertiles of c-f PWV. After adjustment for potential confounders, the hazard ratio of diabetes was 1.00 (reference), 1.83 (95% CI 0.88-3.8), and 3.24 (95% CI 1.51-6.97), respectively, for the tertiles of c-f PWV (P for trend = 0.002). CONCLUSIONS: Increased c-f PWV is associated with increased incidence of diabetes, independent of other risk factors. These results suggest that increased arterial stiffness is an early risk marker for developing diabetes.
Authors: Bianca Cristina Antunes Alves Marques; Márcia Regina Simas Torres Klein; Michelle Rabello da Cunha; Samanta de Souza Mattos; Lívia de Paula Nogueira; Tainah de Paula; Flávia Miranda Corrêa; Wille Oigman; Mario Fritsch Neves Journal: High Blood Press Cardiovasc Prev Date: 2019-12-16
Authors: Ramachandran S Vasan; Stephanie Pan; Vanessa Xanthakis; Alexa Beiser; Martin G Larson; Sudha Seshadri; Gary F Mitchell Journal: Hypertension Date: 2022-02-16 Impact factor: 10.190
Authors: Jordana B Cohen; Gary F Mitchell; Dipender Gill; Stephen Burgess; Mahboob Rahman; Thomas C Hanff; Vasan S Ramachandran; Karen M Mutalik; Raymond R Townsend; Julio A Chirinos Journal: Circ Res Date: 2022-08-10 Impact factor: 23.213
Authors: Yuri D Foreman; William P T M van Doorn; Nicolaas C Schaper; Marleen M J van Greevenbroek; Carla J H van der Kallen; Ronald M A Henry; Annemarie Koster; Simone J P M Eussen; Anke Wesselius; Koen D Reesink; Miranda T Schram; Pieter C Dagnelie; Abraham A Kroon; Martijn C G J Brouwers; Coen D A Stehouwer Journal: Diabetologia Date: 2021-05-15 Impact factor: 10.122
Authors: Per Swärd; Rafid Tofik; Omran Bakoush; Ole Torffvit; Peter M Nilsson; Anders Christensson Journal: BMC Cardiovasc Disord Date: 2020-08-05 Impact factor: 2.298