Tomasz Czarnik1, Aneta Czarnik2, Ryszard Gawda3, Maciej Gawor3, Maciej Piwoda3, Maciej Marszalski3, Magdalena Maj3, Olimpia Chrzan3, Rahim Said3, Maja Rusek-Skora3, Marta Ornat3, Kamil Filipiak3, Jakub Stachowicz3, Robert Kaplon4, Miroslaw Czuczwar5. 1. Department of Anesthesiology and Critical Care, PS ZOZ Wojewodzkie Centrum Medyczne w Opolu, Aleja Witosa 26, 45-418 Opole, Poland. Electronic address: tczarnik@mac.com. 2. Department of Endocrinology, Szpital Wojewodzki w Opolu, ul. Kosnego 53, 45-372 Opole, Poland. 3. Department of Anesthesiology and Critical Care, PS ZOZ Wojewodzkie Centrum Medyczne w Opolu, Aleja Witosa 26, 45-418 Opole, Poland. 4. Department of Operations Research, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland. 5. 2nd Department of Anesthesiology and Critical Care, Medical University of Lublin, ul. Staszica 16, 20-081 Lublin, Poland.
Abstract
PURPOSE: The objective of this study was to assess the vitamin D kinetics in critically ill patients by performing periodic serum vitamin D measurements in short time intervals in the initial phase of a critical illness. MATERIALS AND METHODS: We performed vitamin D serum measurements: at admission and then in 12-hour time intervals. The minimum number of vitamin D measurements was 4, and the maximum was 8 per patient. RESULTS: A total of 363 patients were evaluated for participation, and 20 met the inclusion criteria. All patients had an initial serum vitamin D level between 10.6 and 39ng/mL. Nineteen patients had vitamin D levels between 10 and 30ng/mL, which means that they had vitamin D insufficiency or deficiency, and only one patient had a normal vitamin D serum plasma level. We observed that the median of the vitamin D level decreases until the fourth measurement then stabilizes around the 4th and 5th measurement and then appears to increase unevenly. The highest drop is at the very beginning. CONCLUSIONS: The vitamin D serum level is changeable in the initial phase of a critical illness. We hypothesize that the serum vitamin D concentration can mirror the severity of illness.
PURPOSE: The objective of this study was to assess the vitamin D kinetics in critically illpatients by performing periodic serum vitamin D measurements in short time intervals in the initial phase of a critical illness. MATERIALS AND METHODS: We performed vitamin D serum measurements: at admission and then in 12-hour time intervals. The minimum number of vitamin D measurements was 4, and the maximum was 8 per patient. RESULTS: A total of 363 patients were evaluated for participation, and 20 met the inclusion criteria. All patients had an initial serum vitamin D level between 10.6 and 39ng/mL. Nineteen patients had vitamin D levels between 10 and 30ng/mL, which means that they had vitamin Dinsufficiency or deficiency, and only one patient had a normal vitamin D serum plasma level. We observed that the median of the vitamin D level decreases until the fourth measurement then stabilizes around the 4th and 5th measurement and then appears to increase unevenly. The highest drop is at the very beginning. CONCLUSIONS: The vitamin D serum level is changeable in the initial phase of a critical illness. We hypothesize that the serum vitamin D concentration can mirror the severity of illness.
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