Literature DB >> 28968192

Harnessing the Properties of Natural Products.

Asmaa Boufridi1, Ronald J Quinn1.   

Abstract

Natural products (NPs) have been used as traditional medicines since antiquity. With more than 1060 estimated compounds with molecular weights less than 500 Da representing chemical space, NPs occupy a very small percentage; however, they are significantly overrepresented in biologically relevant chemical space. The classical approach concentrates on identifying one or more NPs with biological activity from a source organism. There is much more to be learned from NPs than we can discover this narrow view. In this review, we discuss ways to harness the global properties of NPs.

Keywords:  bioactive compounds; chemical space; natural products; physicochemical properties; traditional medicine; unique vectors evolved by nature

Mesh：

Substances：

Year:  2017        PMID： 28968192     DOI： 10.1146/annurev-pharmtox-010716-105029

Source DB:  PubMed          Journal:  Annu Rev Pharmacol Toxicol        ISSN： 0362-1642            Impact factor:   13.820


  14 in total

Review 1.  Deep learning approaches for natural product discovery from plant endophytic microbiomes.

Authors:  Shiva Abdollahi Aghdam; Amanda May Vivian Brown
Journal:  Environ Microbiome       Date:  2021-03-18

2.  Precursor-Guided Mining of Marine Sponge Metabolomes Lends Insight into Biosynthesis of Pyrrole-Imidazole Alkaloids.

Authors:  Ipsita Mohanty; Samuel G Moore; Dongqi Yi; Jason S Biggs; David A Gaul; Neha Garg; Vinayak Agarwal
Journal:  ACS Chem Biol       Date:  2020-07-29       Impact factor: 5.100

3.  RI75, a curcumin analogue, inhibits tumor necrosis factor-α and interleukin-6 production and exhibits antiallodynic and antiedematogenic activities in mice.

Authors:  Sarah O A M Costa; Ianny B Rodrigues; Alysson V Braga; Bárbara C M Barbosa; Roger R L Silva; Felipe F Rodrigues; Ivo S F Melo; Marcela Í Morais; Brenda F M Castro; Armando S Cunha Júnior; Vinícius G Maltarollo; Renata B Oliveira; Márcio M Coelho; Renes R Machado
Journal:  Inflammopharmacology       Date:  2022-01-30       Impact factor: 4.473

Review 4.  MicroED in natural product and small molecule research.

Authors:  Emma Danelius; Steve Halaby; Wilfred A van der Donk; Tamir Gonen
Journal:  Nat Prod Rep       Date:  2020-09-17       Impact factor: 13.423

5.  A robust and miniaturized screening platform to study natural products affecting metabolism and survival in Caenorhabditis elegans.

Authors:  Julia Zwirchmayr; Benjamin Kirchweger; Theresa Lehner; Ammar Tahir; Dagmar Pretsch; Judith M Rollinger
Journal:  Sci Rep       Date:  2020-07-23       Impact factor: 4.379

Review 6.  Gut Microbiota, Short-Chain Fatty Acids, and Herbal Medicines.

Authors:  Wuwen Feng; Hui Ao; Cheng Peng
Journal:  Front Pharmacol       Date:  2018-11-23       Impact factor: 5.810

7.  Furanoic Lipid F-6, A Novel Anti-Cancer Compound that Kills Cancer Cells by Suppressing Proliferation and Inducing Apoptosis.

Authors:  Jassim M Al-Hassan; Yuan Fang Liu; Meraj A Khan; Peiying Yang; Rui Guan; Xiao-Yan Wen; Mohammad Afzal; Sosamma Oommen; Bincy M Paul; Divya Nair; Nades Palaniyar; Cecil Pace-Asciak
Journal:  Cancers (Basel)       Date:  2019-07-09       Impact factor: 6.639

8.  A Biochemometric Approach for the Identification of In Vitro Anti-Inflammatory Constituents in Masterwort.

Authors:  Julia Zwirchmayr; Ulrike Grienke; Scarlet Hummelbrunner; Jaqueline Seigner; Rainer de Martin; Verena M Dirsch; Judith M Rollinger
Journal:  Biomolecules       Date:  2020-04-28

Review 9.  Cheminformatic Characterization of Natural Antimicrobial Products for the Development of New Lead Compounds.

Authors:  Samson Olaitan Oselusi; Alan Christoffels; Samuel Ayodele Egieyeh
Journal:  Molecules       Date:  2021-06-29       Impact factor: 4.411

10.  An Integrated Strategy for the Detection, Dereplication, and Identification of DNA-Binding Biomolecules from Complex Natural Product Mixtures.

Authors:  Hongyan Ma; Huiyun Liang; Shengxin Cai; Barry R O'Keefe; Susan L Mooberry; Robert H Cichewicz
Journal:  J Nat Prod       Date:  2020-11-23       Impact factor: 4.803
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