| Literature DB >> 28967925 |
K H Chen1, S P Le, X Han, J M Frias, J S Nowick.
Abstract
An alanine scan of Lys10-teixobactin reveals that a cationic residue at position 10 is not necessary for antibiotic activity and that position 3 tolerates substitution without loss of activity. An unexpected correlation between poor aqueous solubility and better antibiotic activity of the teixobactin analogues is observed.Entities:
Year: 2017 PMID： 28967925 PMCID： PMC6361391 DOI： 10.1039/c7cc03415f
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222