| Literature DB >> 28967889 |
Panagiotis Symvoulidis1,2,3, Antonella Lauri1,2,3, Anca Stefanoiu4, Michele Cappetta1,2,3, Steffen Schneider3, Hongbo Jia5, Anja Stelzl1,2, Maximilian Koch1, Carlos Cruz Perez1,2, Ahne Myklatun1,2,3, Sabine Renninger6, Andriy Chmyrov1,7, Tobias Lasser4, Wolfgang Wurst2, Vasilis Ntziachristos1,7, Gil G Westmeyer1,2,3.
Abstract
A long-standing objective in neuroscience has been to image distributed neuronal activity in freely behaving animals. Here we introduce NeuBtracker, a tracking microscope for simultaneous imaging of neuronal activity and behavior of freely swimming fluorescent reporter fish. We showcase the value of NeuBtracker for screening neurostimulants with respect to their combined neuronal and behavioral effects and for determining spontaneous and stimulus-induced spatiotemporal patterns of neuronal activation during naturalistic behavior.Mesh：
Year: 2017 PMID： 28967889 DOI： 10.1038/nmeth.4459
Source DB: PubMed Journal: Nat Methods ISSN： 1548-7091 Impact factor: 28.547