Literature DB >> 28966883

MicroRNAs in Cancer: challenges and opportunities in early detection, disease monitoring, and therapeutic agents.

Namita Chatterjee1, Shushan Rana2, Cristina Espinosa-Diez1, Sudarshan Anand1,2.   

Abstract

PURPOSE OF REVIEW: The goals of this review are to examine the usefulness of miRNAs as diagnostic and prognostic biomarkers for cancer and to evaluate the applicability of miRNAs as cancer therapeutics. RECENT
FINDINGS: Examination of miRNA milieu from body fluids offers a new alternative for quick, affordable and easy analysis of disease status in patients. Blood-based exosomal miRNAs have increased stability and are an excellent choice for clinical cancer diagnostics and prognostics. Currently, there are many miRNA signatures associated with cancer and progression but there is no consensus among multiple sera and tumor sample studies. Off-target and immunological effects remains an obstacle for use of miRNAs as novel chemotherapeutics in the clinic. Recent developments in nanotechnology and drug delivery systems which target the tumor microenvironment may provide an alternative therapeutic approach with decreased toxicity.
SUMMARY: This review critically evaluates the literature investigating the use of miRNAs as biomarkers and their future as potential therapeutics.

Entities:  

Keywords:  biomarker; cancer; chemotherapy; exosomes; microRNA; tumor microenvironment

Year:  2017        PMID： 28966883      PMCID： PMC5613763          DOI： 10.1007/s40139-017-0123-0

Source DB:  PubMed          Journal:  Curr Pathobiol Rep        ISSN： 2167-485X


  71 in total

1.  A plasma microRNA panel for detection of colorectal adenomas: a step toward more precise screening for colorectal cancer.

Authors:  Ziad Kanaan; Henry Roberts; M Robert Eichenberger; Adrian Billeter; Gairy Ocheretner; Jianmin Pan; Shesh N Rai; Jeffery Jorden; Anna Williford; Susan Galandiuk
Journal:  Ann Surg       Date:  2013-09       Impact factor: 12.969

2.  microRNAs derived from circulating exosomes as noninvasive biomarkers for screening and diagnosing lung cancer.

Authors:  Riccardo Cazzoli; Fiamma Buttitta; Marta Di Nicola; Sara Malatesta; Antonio Marchetti; William N Rom; Harvey I Pass
Journal:  J Thorac Oncol       Date:  2013-09       Impact factor: 15.609

3.  The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis.

Authors:  Bernhard Mlecnik; Gabriela Bindea; Amos Kirilovsky; Helen K Angell; Anna C Obenauf; Marie Tosolini; Sarah E Church; Pauline Maby; Angela Vasaturo; Mihaela Angelova; Tessa Fredriksen; Stéphanie Mauger; Maximilian Waldner; Anne Berger; Michael R Speicher; Franck Pagès; Viia Valge-Archer; Jérôme Galon
Journal:  Sci Transl Med       Date:  2016-02-24       Impact factor: 17.956

4.  Investigation of miR-21, miR-141, and miR-221 in blood circulation of patients with prostate cancer.

Authors:  Fulya Yaman Agaoglu; Müge Kovancilar; Yavuz Dizdar; Emin Darendeliler; Stefan Holdenrieder; Nejat Dalay; Ugur Gezer
Journal:  Tumour Biol       Date:  2011-01-28

5.  Serum-based microRNA signatures in early diagnosis and prognosis prediction of colon cancer.

Authors:  Petra Vychytilova-Faltejskova; Lenka Radova; Milana Sachlova; Zdenka Kosarova; Katerina Slaba; Pavel Fabian; Tomas Grolich; Vladimir Prochazka; Zdenek Kala; Marek Svoboda; Igor Kiss; Rostislav Vyzula; Ondrej Slaby
Journal:  Carcinogenesis       Date:  2016-08-01       Impact factor: 4.944

Review 6.  The biological functions of miRNAs: lessons from in vivo studies.

Authors:  Joana A Vidigal; Andrea Ventura
Journal:  Trends Cell Biol       Date:  2014-12-04       Impact factor: 20.808

7.  Systemic delivery of a miR34a mimic as a potential therapeutic for liver cancer.

Authors:  Christopher L Daige; Jason F Wiggins; Leslie Priddy; Terri Nelligan-Davis; Jane Zhao; David Brown
Journal:  Mol Cancer Ther       Date:  2014-07-22       Impact factor: 6.261

8.  Differential stability of cell-free circulating microRNAs: implications for their utilization as biomarkers.

Authors:  Verena Köberle; Thomas Pleli; Christian Schmithals; Eduardo Augusto Alonso; Jörg Haupenthal; Halvard Bönig; Jan Peveling-Oberhag; Ricardo M Biondi; Stefan Zeuzem; Bernd Kronenberger; Oliver Waidmann; Albrecht Piiper
Journal:  PLoS One       Date:  2013-09-20       Impact factor: 3.240

9.  In-depth analysis shows synergy between erlotinib and miR-34a.

Authors:  Jane Zhao; Kevin Kelnar; Andreas G Bader
Journal:  PLoS One       Date:  2014-02-14       Impact factor: 3.240

10.  microRNA expression profiling on individual breast cancer patients identifies novel panel of circulating microRNA for early detection.

Authors:  Rimi Hamam; Arwa M Ali; Khalid A Alsaleh; Moustapha Kassem; Musaed Alfayez; Abdullah Aldahmash; Nehad M Alajez
Journal:  Sci Rep       Date:  2016-05-16       Impact factor: 4.379
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  6 in total

Review 1.  Cervical cancer development, chemoresistance, and therapy: a snapshot of involvement of microRNA.

Authors:  Tandrima Mitra; Selvakumar Elangovan
Journal:  Mol Cell Biochem       Date:  2021-08-28       Impact factor: 3.396

Review 2.  Potentiality of Exosomal Proteins as Novel Cancer Biomarkers for Liquid Biopsy.

Authors:  Chunmiao Hu; Wei Jiang; Mingjin Lv; Shuhao Fan; Yujia Lu; Qingjun Wu; Jiang Pi
Journal:  Front Immunol       Date:  2022-06-09       Impact factor: 8.786

Review 3.  Messenger RNA Life-Cycle in Cancer Cells: Emerging Role of Conventional and Non-Conventional RNA-Binding Proteins?

Authors:  Lucie Coppin; Julie Leclerc; Audrey Vincent; Nicole Porchet; Pascal Pigny
Journal:  Int J Mol Sci       Date:  2018-02-25       Impact factor: 5.923

4.  RegenDbase: a comparative database of noncoding RNA regulation of tissue regeneration circuits across multiple taxa.

Authors:  Benjamin L King; Michael C Rosenstein; Ashley M Smith; Christina A Dykeman; Grace A Smith; Viravuth P Yin
Journal:  NPJ Regen Med       Date:  2018-05-29

5.  Bortezomib Sustains T Cell Function by Inducing miR-155-Mediated Downregulation of SOCS1 and SHIP1.

Authors:  Ariana N Renrick; Menaka C Thounaojam; Maria Teresa P de Aquino; Evan Chaudhuri; Jui Pandhare; Chandravanu Dash; Anil Shanker
Journal:  Front Immunol       Date:  2021-02-25       Impact factor: 7.561

6.  Upregulated hsa_circ_0004458 Contributes to Progression of Papillary Thyroid Carcinoma by Inhibition of miR-885-5p and Activation of RAC1.

Authors:  Xiaoyan Jin; Zhengyi Wang; Wenyang Pang; Jian Zhou; Yong Liang; Jingjin Yang; Linjun Yang; Qiang Zhang
Journal:  Med Sci Monit       Date:  2018-08-07
  6 in total

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