Po-Wen Ku1, Yi-Te Liu2, Ming-Kuei Lo3, Li-Jung Chen4, Brendon Stubbs5. 1. Graduate Institute of Sports and Health, National Changhua University of Education, Taiwan. Electronic address: powen@cc.ncue.edu.tw. 2. Department of Sports, National Changhua University of Education, Taiwan. Electronic address: ytliu@cc.ncue.edu.tw. 3. Department of Leisure Business Management, Nan Kai University of Technology, Taiwan. Electronic address: kuei@nkut.edu.tw. 4. Department of Exercise Health Science, National Taiwan University of Sport, Taiwan. Electronic address: ljchen@gm.ntupes.edu.tw. 5. Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill, London SE5 8AZ, UK; Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London Box SE5 8AF, UK; Faculty of Health, Social Care and Education, Anglia Ruskin University, Chelmsford, UK. Electronic address: brendon.stubbs@kcl.ac.uk.
Abstract
BACKGROUND: A number of cross-sectional studies have suggested that higher levels of sedentary behavior (SB) are associated with worse cognitive abilities in older age. There is a paucity of longitudinal studies investigating this relationship utilizing objectively assessed SB. This study investigated the relationship between objectively assessed SB and future cognitive abilities in a cohort of older adults. METHODS: A longitudinal study over 22.12±1.46months including 285 community-dwelling older adults across 14 regions in Taiwan was undertaken. Cognitive ability was ascertained using a Chinese version of the Ascertain Dementia 8-item Questionnaire (AD8) and SB captured by 7days accelerometer data. Multivariable negative binomial regression models adjusted for confounders were undertaken. RESULTS: 274 community-dwelling older adults finished the study (age=74.6±6.2, % female=54.4%). At baseline, 20.1% (n=55), 48.5% (n=133) and 31.4% (n=86) of the sample engaged in high (11+h), medium (7-10.99h) and low (<7h) of SB respectively. In the fully adjusted model, higher levels of SB were associated with an increased risk of worse cognitive ability at follow up (adjusted rate ratio (ARR)1.09 (95%CI:1.00-1.19)), with the strongest relationship evident in those engaging in over 11h of SB (ARR 2.27 (95%CI:1.24-4.16)). The relationship remained evident after adjusting for depressive symptoms and physical activity. CONCLUSION: Our data suggests that objectively assessed SB, particularly when over 11h a day, is independently associated with worse cognitive ability over a two year period. Our data adds to the pressing reasons to reduced SB in older age.
BACKGROUND: A number of cross-sectional studies have suggested that higher levels of sedentary behavior (SB) are associated with worse cognitive abilities in older age. There is a paucity of longitudinal studies investigating this relationship utilizing objectively assessed SB. This study investigated the relationship between objectively assessed SB and future cognitive abilities in a cohort of older adults. METHODS: A longitudinal study over 22.12±1.46months including 285 community-dwelling older adults across 14 regions in Taiwan was undertaken. Cognitive ability was ascertained using a Chinese version of the Ascertain Dementia 8-item Questionnaire (AD8) and SB captured by 7days accelerometer data. Multivariable negative binomial regression models adjusted for confounders were undertaken. RESULTS: 274 community-dwelling older adults finished the study (age=74.6±6.2, % female=54.4%). At baseline, 20.1% (n=55), 48.5% (n=133) and 31.4% (n=86) of the sample engaged in high (11+h), medium (7-10.99h) and low (<7h) of SB respectively. In the fully adjusted model, higher levels of SB were associated with an increased risk of worse cognitive ability at follow up (adjusted rate ratio (ARR)1.09 (95%CI:1.00-1.19)), with the strongest relationship evident in those engaging in over 11h of SB (ARR 2.27 (95%CI:1.24-4.16)). The relationship remained evident after adjusting for depressive symptoms and physical activity. CONCLUSION: Our data suggests that objectively assessed SB, particularly when over 11h a day, is independently associated with worse cognitive ability over a two year period. Our data adds to the pressing reasons to reduced SB in older age.
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