Literature DB >> 2895896

Divergent homeo box proteins recognize similar DNA sequences in Drosophila.

T Hoey1, M Levine.   

Abstract

A member of a small group of genes in Drosophila that define the segmentation pattern of the early embryo even-skipped (eve), which plays a key role in a network of interactions among segmentation genes. It appears to control morphogenesis by regulating the expression of the segmentation gene engrailed (en), and by autoregulating its own expression (M. Frasch and M.L., in preparation). Here we show that these regulatory interactions could occur at the level of transcription as a full-length eve protein binds with high affinity to specific sequences located near the 5' ends of the eve and en genes. The en binding sites contain at least one copy of a 10-base pair consensus sequence: T-C-A-A-T-T-A-A-A-T. In contrast, the 5' eve binding sites are relatively G-C rich and do not share obvious similarities with the 10-base pair consensus sequence associated with en. Other homeo box proteins can recognize both classes of eve binding sites, lending support to the proposal that regulatory interactions among homeo box genes involve a competition of different homeo box proteins for similar cis regulatory sequences.

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Year:  1988        PMID: 2895896     DOI: 10.1038/332858a0

Source DB:  PubMed          Journal:  Nature        ISSN: 0028-0836            Impact factor:   49.962


  152 in total

1.  A comparison of in vivo and in vitro DNA-binding specificities suggests a new model for homeoprotein DNA binding in Drosophila embryos.

Authors:  A Carr; M D Biggin
Journal:  EMBO J       Date:  1999-03-15       Impact factor: 11.598

2.  Regulation by homeoproteins: a comparison of deformed-responsive elements.

Authors:  J A Pederson; J W LaFollette; C Gross; A Veraksa; W McGinnis; J W Mahaffey
Journal:  Genetics       Date:  2000-10       Impact factor: 4.562

3.  A novel murine homeobox gene isolated by a tissue specific PCR cloning strategy.

Authors:  M J Kern; D P Witte; M T Valerius; B J Aronow; S S Potter
Journal:  Nucleic Acids Res       Date:  1992-10-11       Impact factor: 16.971

4.  Hoxb4 in oligodendrogenesis.

Authors:  Danette J Nicolay; J Ronald Doucette; Adil J Nazarali
Journal:  Cell Mol Neurobiol       Date:  2004-06       Impact factor: 5.046

5.  The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promoters.

Authors:  C Herrero Sanchez; W Reith; P Silacci; B Mach
Journal:  Mol Cell Biol       Date:  1992-09       Impact factor: 4.272

6.  Binding sites for two novel phosphoproteins, 3AF5 and 3AF3, are required for rbcS-3A expression.

Authors:  L P Sarokin; N H Chua
Journal:  Plant Cell       Date:  1992-04       Impact factor: 11.277

7.  A binding site for homeodomain and Pax proteins is necessary for L1 cell adhesion molecule gene expression by Pax-6 and bone morphogenetic proteins.

Authors:  R Meech; P Kallunki; G M Edelman; F S Jones
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-02       Impact factor: 11.205

8.  Engrailed and Hox homeodomain proteins contain a related Pbx interaction motif that recognizes a common structure present in Pbx.

Authors:  L T Peltenburg; C Murre
Journal:  EMBO J       Date:  1996-07-01       Impact factor: 11.598

9.  Identification of 10 murine homeobox genes.

Authors:  G Singh; S Kaur; J L Stock; N A Jenkins; D J Gilbert; N G Copeland; S S Potter
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-01       Impact factor: 11.205

10.  Expression and in vitro function of beta 1-integrin laminin receptors in the developing avian ciliary ganglion.

Authors:  C D Weaver; C K Yoshida; I de Curtis; L F Reichardt
Journal:  J Neurosci       Date:  1995-07       Impact factor: 6.167

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