Anna Paula W Baptista Sincos1, Angela Mazzeo2, Igor Rafael Sincos3, Felipe Coelho Neto3, Nelson Wolosker3, Ricardo Aun3, Katia R M Leite4, Vitoria Penido de Paula2, Oskar G Kaufmann3. 1. Division of Vascular Surgery, Department of Surgery, Hospital Israelita Albert Einstein, São Paulo, Brazil. Electronic address: draanna@endovascularsp.com.br. 2. Albert Einstein Israeli Institute of Teaching and Research and Albert Einstein Israeli College of Health Sciences, São Paulo, Brazil. 3. Division of Vascular Surgery, Department of Surgery, Hospital Israelita Albert Einstein, São Paulo, Brazil. 4. Division of Pathology, Department of Anatomy, Clinics Hospital, University of São Paulo, São Paulo, Brazil.
Abstract
OBJECTIVE: The objective of this study was to identify the effect of two left renal vasculature occlusion strategies on the duplex ultrasound-assessed rheology and histology of the contralateral kidney. METHODS: Pigs were randomly assigned to one of two groups: left renal artery-only clamping (A group, n = 8) or left renal artery and vein clamping (AV group, n = 9). Bilateral renal parenchymal biopsy specimens were taken every 10 minutes for 90 minutes. Duplex ultrasound resistive index (RI) and pulsatility index (PI) were measured. Mixed models with normal distribution and first-order autoregressive correlation structure and generalized estimating equation models were used. Results are presented as adjusted means with standard errors, estimated proportions with standard errors, and line plots with 95% confidence intervals. RESULTS: RI and PI increased in the nonischemic kidney. In A group animals, RI values increased significantly (P < .01) after 30 minutes of ischemia and PI increased significantly (P < .04) from 30 to 60 minutes of ischemia. The number of histologic abnormalities was higher in A group than in AV group biopsy specimens. The percentage of lesions increased significantly after 10 minutes in A group nonischemic kidneys (P < .02) and between 50 and 80 minutes in AV group nonischemic kidneys (P < .01). CONCLUSIONS: Nonischemic kidneys were acutely affected by contralateral ischemia. Their function was more adversely affected by unilateral renal artery occlusion with preserved renal vein patency (A group).
OBJECTIVE: The objective of this study was to identify the effect of two left renal vasculature occlusion strategies on the duplex ultrasound-assessed rheology and histology of the contralateral kidney. METHODS:Pigs were randomly assigned to one of two groups: left renal artery-only clamping (A group, n = 8) or left renal artery and vein clamping (AV group, n = 9). Bilateral renal parenchymal biopsy specimens were taken every 10 minutes for 90 minutes. Duplex ultrasound resistive index (RI) and pulsatility index (PI) were measured. Mixed models with normal distribution and first-order autoregressive correlation structure and generalized estimating equation models were used. Results are presented as adjusted means with standard errors, estimated proportions with standard errors, and line plots with 95% confidence intervals. RESULTS: RI and PI increased in the nonischemic kidney. In A group animals, RI values increased significantly (P < .01) after 30 minutes of ischemia and PI increased significantly (P < .04) from 30 to 60 minutes of ischemia. The number of histologic abnormalities was higher in A group than in AV group biopsy specimens. The percentage of lesions increased significantly after 10 minutes in A group nonischemic kidneys (P < .02) and between 50 and 80 minutes in AV group nonischemic kidneys (P < .01). CONCLUSIONS: Nonischemic kidneys were acutely affected by contralateral ischemia. Their function was more adversely affected by unilateral renal artery occlusion with preserved renal vein patency (A group).
Authors: Anna Paula Weinhardt Baptista-Strazzi; Ricardo Aun; Igor Rafael Sincos; Allana M Tobita; Maria Fernanda Cassino Portugal; Vitória Penido de Paula; Oskar Kaufmann; Nelson Wolosker Journal: Clinics (Sao Paulo) Date: 2021-05-21 Impact factor: 2.365
Authors: Angela Mazzeo; Anna Paula Weinhardt Baptista Sincos; Katia Ramos Moreira Leite; Miguel Angelo Góes; Oscar Fernando Santos Dos Pavão; Oskar Grau Kaufmann Journal: Int Braz J Urol Date: 2019 Jul-Aug Impact factor: 1.541
Authors: Jacob Hindrik Antunes Smit; Eduardo Piotto Leonardi; Rosa Helena de Figueiredo Chaves; Ismari Perini Furlaneto; Cezar Massoud Salame da Silva; Simone de Campos Vieira Abib; Adenauer Marinho de Oliveira Góes Junior Journal: Acta Cir Bras Date: 2021-01-20 Impact factor: 1.388
Authors: Carolina Rodrigues Dal Bo; Vitória Penido de Paula; Anna Paula Weinhardt Baptista Strazzi; Nelson Wolosker; Thiago Pinheiro Arrais Aloia; Angela Mazzeo; Oskar Grau Kaufmann Journal: J Vasc Bras Date: 2021-07-12