Literature DB >> 28956690

The anti-aging promise of p21.

Nurit Papismadov1, Hilah Gal1, Valery Krizhanovsky1.   

Abstract

Entities:  

Keywords:  DNA damage response (DDR); JNK; aging; apoptosis; cellular senescence; extra cellular matrix (ECM); fibrosis; p21(CDKN1A)

Mesh：

Substances：

Year:  2017        PMID： 28956690      PMCID： PMC5731409          DOI： 10.1080/15384101.2017.1377500

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


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  7 in total

1.  Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation.

Authors:  Aaheli Roy Choudhury; Zhenyu Ju; Meta W Djojosubroto; Andrea Schienke; Andre Lechel; Sonja Schaetzlein; Hong Jiang; Anna Stepczynska; Chunfang Wang; Jan Buer; Han-Woong Lee; Thomas von Zglinicki; Arnold Ganser; Peter Schirmacher; Hiromitsu Nakauchi; K Lenhard Rudolph
Journal:  Nat Genet       Date:  2006-12-03       Impact factor: 38.330

Review 2.  p21 in cancer: intricate networks and multiple activities.

Authors:  Tarek Abbas; Anindya Dutta
Journal:  Nat Rev Cancer       Date:  2009-06       Impact factor: 60.716

3.  Senescent cells communicate via intercellular protein transfer.

Authors:  Anat Biran; Meirav Perelmutter; Hilah Gal; Dominick G A Burton; Yossi Ovadya; Ezra Vadai; Tamar Geiger; Valery Krizhanovsky
Journal:  Genes Dev       Date:  2015-04-08       Impact factor: 11.361

4.  NKG2D ligands mediate immunosurveillance of senescent cells.

Authors:  Adi Sagiv; Dominick G A Burton; Zhana Moshayev; Ezra Vadai; Felix Wensveen; Shifra Ben-Dor; Ofra Golani; Bojan Polic; Valery Krizhanovsky
Journal:  Aging (Albany NY)       Date:  2016-02       Impact factor: 5.682

5.  p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling.

Authors:  Reut Yosef; Noam Pilpel; Nurit Papismadov; Hilah Gal; Yossi Ovadya; Ezra Vadai; Stav Miller; Ziv Porat; Shifra Ben-Dor; Valery Krizhanovsky
Journal:  EMBO J       Date:  2017-06-12       Impact factor: 11.598

Review 6.  Physiological and pathological consequences of cellular senescence.

Authors:  Dominick G A Burton; Valery Krizhanovsky
Journal:  Cell Mol Life Sci       Date:  2014-07-31       Impact factor: 9.261

7.  Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL.

Authors:  Reut Yosef; Noam Pilpel; Ronit Tokarsky-Amiel; Anat Biran; Yossi Ovadya; Snir Cohen; Ezra Vadai; Liat Dassa; Elisheva Shahar; Reba Condiotti; Ittai Ben-Porath; Valery Krizhanovsky
Journal:  Nat Commun       Date:  2016-04-06       Impact factor: 14.919
  7 in total
  8 in total

Review 1.  Strategies targeting cellular senescence.

Authors:  Yossi Ovadya; Valery Krizhanovsky
Journal:  J Clin Invest       Date:  2018-04-02       Impact factor: 14.808

2.  Co-inhibition of ATM and ROCK synergistically improves cell proliferation in replicative senescence by activating FOXM1 and E2F1.

Authors:  Eun Jae Yang; Ji Hwan Park; Hyun-Ji Cho; Jeong-A Hwang; Seung-Hwa Woo; Chi Hyun Park; Sung Young Kim; Joon Tae Park; Sang Chul Park; Daehee Hwang; Young-Sam Lee
Journal:  Commun Biol       Date:  2022-07-14

3.  Effects of long-term resveratrol treatment in hypothalamic astrocyte cultures from aged rats.

Authors:  Vanessa Sovrani; Larissa Daniele Bobermin; Camila Leite Santos; Morgana Brondani; Carlos-Alberto Gonçalves; Guilhian Leipnitz; André Quincozes-Santos
Journal:  Mol Cell Biochem       Date:  2022-10-22       Impact factor: 3.842

4.  Absence of p21(WAF1/CIP1/SDI1) protects against osteopenia and minimizes bone loss after ovariectomy in a mouse model.

Authors:  Priyatha Premnath; Leah Ferrie; Dante Louie; Steven Boyd; Roman Krawetz
Journal:  PLoS One       Date:  2019-04-10       Impact factor: 3.240

Review 5.  Senescence in chronic wounds and potential targeted therapies.

Authors:  Xuerong Wei; Minxiong Li; Zijun Zheng; Jun Ma; Yanbin Gao; Lianglong Chen; Yujie Peng; Shengxiang Yu; Lei Yang
Journal:  Burns Trauma       Date:  2022-02-17

6.  ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination.

Authors:  Shengjun Geng; Wen Peng; Xue Wang; Xiaosong Hu; Hanghua Liang; Jianbing Hou; Feng Wang; Gaichao Zhao; Muhan Lü; Hongjuan Cui
Journal:  Cell Death Dis       Date:  2022-06-22       Impact factor: 9.685

7.  α-Glyceryl-phosphoryl-ethanolamine protects human hippocampal neurons from ageing-induced cellular alterations.

Authors:  Elisa Zappelli; Simona Daniele; Lorenzo Ceccarelli; Matteo Vergassola; Lorella Ragni; Giorgina Mangano; Claudia Martini
Journal:  Eur J Neurosci       Date:  2022-08-12       Impact factor: 3.698

8.  Carbofuran accelerates the cellular senescence and declines the life span of spns1 mutant zebrafish.

Authors:  Alam Khan; Talukdar Mohammad Fahad; Tanjima Akther; Tanjeena Zaman; Md Faruk Hasan; Md Rafiqual Islam Khan; Mohammad Saiful Islam; Shuji Kishi
Journal:  J Cell Mol Med       Date:  2020-12-04       Impact factor: 5.295
  8 in total

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