Literature DB >> 28956314

New Insights in Cardiac Calcium Handling and Excitation-Contraction Coupling.

Jessica Gambardella1,2, Bruno Trimarco1, Guido Iaccarino2, Gaetano Santulli3,4.   

Abstract

Excitation-contraction (EC) coupling denotes the conversion of electric stimulus in mechanic output in contractile cells. Several studies have demonstrated that calcium (Ca2+) plays a pivotal role in this process. Here we present a comprehensive and updated description of the main systems involved in cardiac Ca2+ handling that ensure a functional EC coupling and their pathological alterations, mainly related to heart failure.

Entities:  

Keywords:  Calcium; Contraction; Heart Failure; Mitochondria; RyR; SerCa

Mesh：

Substances：

Year:  2018        PMID： 28956314      PMCID： PMC5889357          DOI： 10.1007/5584_2017_106

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  129 in total

1.  T-tubule localization of the inward-rectifier K(+) channel in mouse ventricular myocytes: a role in K(+) accumulation.

Authors:  R B Clark; A Tremblay; P Melnyk; B G Allen; W R Giles; C Fiset
Journal:  J Physiol       Date:  2001-12-15       Impact factor: 5.182

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Authors:  J Keizer; L Levine
Journal:  Biophys J       Date:  1996-12       Impact factor: 4.033

Review 3.  Mitochondria in Structural and Functional Cardiac Remodeling.

Authors:  Natalia Torrealba; Pablo Aranguiz; Camila Alonso; Beverly A Rothermel; Sergio Lavandero
Journal:  Adv Exp Med Biol       Date:  2017       Impact factor: 2.622

4.  Ca 2+ -binding and Ca 2+ -sensitizing functions of cardiac native tropomyosin, troponin, and tropomyosin.

Authors:  Y S Reddy; C R Honig
Journal:  Biochim Biophys Acta       Date:  1972-09-20

5.  Mitochondrial Ca2+ uptake contributes to buffering cytoplasmic Ca2+ peaks in cardiomyocytes.

Authors:  Ilaria Drago; Diego De Stefani; Rosario Rizzuto; Tullio Pozzan
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-20       Impact factor: 11.205

6.  Three amino acid residues determine selective binding of FK506-binding protein 12.6 to the cardiac ryanodine receptor.

Authors:  H B Xin; K Rogers; Y Qi; T Kanematsu; S Fleischer
Journal:  J Biol Chem       Date:  1999-05-28       Impact factor: 5.157

7.  Protective effect of JTV519, a new 1,4-benzothiazepine derivative, on prolonged myocardial preservation.

Authors:  M Hachida; S Kihara; M Nonoyama; H Koyanagi
Journal:  J Card Surg       Date:  1999 May-Jun       Impact factor: 1.620

8.  Assessment of Myofilament Ca2+ Sensitivity Underlying Cardiac Excitation-contraction Coupling.

Authors:  Zai Hao Zhao; Chun Li Jin; Ji Hyun Jang; Yu Na Wu; Sung Joon Kim; Hong Hua Jin; Lan Cui; Yin Hua Zhang
Journal:  J Vis Exp       Date:  2016-08-01       Impact factor: 1.355

9.  Local Ca2+ transients (Ca2+ sparks) originate at transverse tubules in rat heart cells.

Authors:  P S Shacklock; W G Wier; C W Balke
Journal:  J Physiol       Date:  1995-09-15       Impact factor: 5.182

10.  The effects of changes in muscle length during diastole on the calcium transient in ferret ventricular muscle.

Authors:  D G Allen; C G Nichols; G L Smith
Journal:  J Physiol       Date:  1988-12       Impact factor: 5.182
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  30 in total

1.  Dietary fat is a key determinant in balancing mitochondrial dynamics in heart failure: a novel mechanism underlying the obesity paradox.

Authors:  Matteo De Rosa; Jessica Gambardella; Jun Shu; Gaetano Santulli
Journal:  Cardiovasc Res       Date:  2018-06-01       Impact factor: 10.787

2.  Extracellular pH and intracellular phosphatidylinositol 4,5-bisphosphate control Cl- currents in guinea pig detrusor smooth muscle cells.

Authors:  Viktor Yarotskyy; John Malysz; Georgi V Petkov
Journal:  Am J Physiol Cell Physiol       Date:  2019-10-02       Impact factor: 4.249

Review 3.  Ryanodine Receptor Structure and Function in Health and Disease.

Authors:  Gaetano Santulli; Daniel Lewis; Amedee des Georges; Andrew R Marks; Joachim Frank
Journal:  Subcell Biochem       Date:  2018

Review 4.  Heart failure in diabetes.

Authors:  Stanislovas S Jankauskas; Urna Kansakar; Fahimeh Varzideh; Scott Wilson; Pasquale Mone; Angela Lombardi; Jessica Gambardella; Gaetano Santulli
Journal:  Metabolism       Date:  2021-10-08       Impact factor: 8.694

5.  Advances in the understanding of excitation-contraction coupling: the pulsing quest for drugs against heart failure and arrhythmias.

Authors:  Urna Kansakar; Fahimeh Varzideh; Stanislovas S Jankauskas; Jessica Gambardella; Bruno Trimarco; Gaetano Santulli
Journal:  Eur Heart J Cardiovasc Pharmacother       Date:  2021-11-03

6.  Editorial: Mitochondrial Remodeling and Dynamic Inter-Organellar Contacts in Cardiovascular Physiopathology.

Authors:  Gaetano Santulli; Giovanni Monaco; Valentina Parra; Giampaolo Morciano
Journal:  Front Cell Dev Biol       Date:  2021-04-30

7.  Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure.

Authors:  Angela Lombardi; Bruno Trimarco; Guido Iaccarino; Gaetano Santulli
Journal:  Cell Commun Signal       Date:  2017-11-13       Impact factor: 5.712

8.  Phosphoproteomic analysis identifies phospho-Threonine-17 site of phospholamban important in low molecular weight isoform of fibroblast growth factor 2-induced protection against post-ischemic cardiac dysfunction.

Authors:  Janet R Manning; Aruna B Wijeratne; Brian B Oloizia; Yu Zhang; Kenneth D Greis; Jo El J Schultz
Journal:  J Mol Cell Cardiol       Date:  2020-08-25       Impact factor: 5.000

Review 9.  Mitochondrial Bioenergetics and Dynamism in the Failing Heart.

Authors:  Giampaolo Morciano; Veronica Angela Maria Vitto; Esmaa Bouhamida; Carlotta Giorgi; Paolo Pinton
Journal:  Life (Basel)       Date:  2021-05-12

10.  Sirolimus induces depletion of intracellular calcium stores and mitochondrial dysfunction in pancreatic beta cells.

Authors:  Angela Lombardi; Jessica Gambardella; Xue-Liang Du; Daniela Sorriento; Maurizio Mauro; Guido Iaccarino; Bruno Trimarco; Gaetano Santulli
Journal:  Sci Rep       Date:  2017-11-20       Impact factor: 4.379
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