C Cipriani1, J Pepe2, F Bertoldo3, G Bianchi4, F P Cantatore5, A Corrado5, M Di Stefano6, B Frediani7, D Gatti8, A Giustina9, T Porcelli10, G Isaia6, M Rossini8, L Nieddu11, S Minisola2, G Girasole4, M Pedrazzoni12. 1. Department of Internal Medicine and Medical Disciplines, "Sapienza" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy. cristiana.cipriani@gmail.com. 2. Department of Internal Medicine and Medical Disciplines, "Sapienza" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy. 3. Internal Medicine, Department of Medicine, University of Verona, p.le L. Scuro 2, 37134, Verona, Italy. 4. Division of Rheumatology, Department of Locomotor System, ASL3-Azienda Sanitaria Genovese, Genoa, Italy. 5. Rheumatologic Clinic "M. Carrozzo", Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy. 6. Gerontology and Bone Metabolic Disease Section, Molinette Hospital, University of Turin, 10126, Turin, Italy. 7. Department of Rheumatology, Policlinico Le Scotte, University of Siena, Siena, Italy. 8. Rheumatology Section, Department of Medicine, University of Verona, Piazzale L. Scuro 10, 37134, Verona, Italy. 9. Vita-Salute University San Raffaele Milan, Milan, Italy. 10. Presidio Ospedaliero di Montichiari, Via G. Ciotti, 154, 25018, Montichiari, Brescia, Italy. 11. Faculty of Economics, UNINT University, Via Cristoforo Colombo 200, 00147, Rome, Italy. 12. Department of Clinical and Experimental Medicine, University of Parma, Via Gramsci 14, 43126, Parma, Italy.
Abstract
PURPOSE: The study was aimed at evaluating the prevalence of osteoporosis, defined by BMD and the National Bone Health Alliance (NBHA) criteria, and the prevalence of clinical risk factors for fractures in Italian postmenopausal women. METHODS: This is a cross-sectional, multicenter, cohort study evaluating 3247 postmenopausal women aged ≥ 50 and older in different areas of Italy in the period 2012-2014. All the participants were evaluated as far as anthropometrics; questionnaires for FRAX® and DeFRA calculation were administered and bone mineral density was measured at lumbar spine, femoral neck and total hip by DXA. RESULTS: The prevalence of osteoporosis, as assessed by BMD and NBHA criteria was 36.6 and 57%, respectively. Mean ± SD values of FRAX® and DeFRA were: 10.2 ± 7.3 and 11 ± 9.4 for major fractures, and 3.3 ± 4.9 and 3.9 ± 5.9 for hip fractures, respectively. Among clinical risk factors for fracture, the presence of previous fracture, particularly non-spine/non-hip fracture, parental history of hip fracture and current smoking were the most commonly observed. CONCLUSIONS: Our study showed that more that the half of postmenopausal women aged 50 and older in Italy has osteoporosis on the basis of the NBHA criteria. There is a relevant high risk of femur fracture, as assessed by the FRAX® and DeFRA and previous fracture, parental history of hip fracture and current smoking are the most common risk factors. The data should be considered particularly in relation to the need to increase prevention strategies on modifiable risk factors and therapeutic intervention.
PURPOSE: The study was aimed at evaluating the prevalence of osteoporosis, defined by BMD and the National Bone Health Alliance (NBHA) criteria, and the prevalence of clinical risk factors for fractures in Italian postmenopausal women. METHODS: This is a cross-sectional, multicenter, cohort study evaluating 3247 postmenopausal women aged ≥ 50 and older in different areas of Italy in the period 2012-2014. All the participants were evaluated as far as anthropometrics; questionnaires for FRAX® and DeFRA calculation were administered and bone mineral density was measured at lumbar spine, femoral neck and total hip by DXA. RESULTS: The prevalence of osteoporosis, as assessed by BMD and NBHA criteria was 36.6 and 57%, respectively. Mean ± SD values of FRAX® and DeFRA were: 10.2 ± 7.3 and 11 ± 9.4 for major fractures, and 3.3 ± 4.9 and 3.9 ± 5.9 for hip fractures, respectively. Among clinical risk factors for fracture, the presence of previous fracture, particularly non-spine/non-hip fracture, parental history of hip fracture and current smoking were the most commonly observed. CONCLUSIONS: Our study showed that more that the half of postmenopausal women aged 50 and older in Italy has osteoporosis on the basis of the NBHA criteria. There is a relevant high risk of femur fracture, as assessed by the FRAX® and DeFRA and previous fracture, parental history of hip fracture and current smoking are the most common risk factors. The data should be considered particularly in relation to the need to increase prevention strategies on modifiable risk factors and therapeutic intervention.
Authors: M Pedrazzoni; G Girasole; F Bertoldo; G Bianchi; C Cepollaro; A Del Puente; S Giannini; S Gonnelli; D Maggio; C Marcocci; S Minisola; E Palummeri; M Rossini; L Sartori; L Sinigaglia Journal: Osteoporos Int Date: 2003-10-03 Impact factor: 4.507
Authors: J Pepe; C Cipriani; F P Cantatore; A Fabbri; E Pola; V Vinicola; O Raimo; F Biamonte; R Pascone; C Ferrara; S Minisola Journal: J Endocrinol Invest Date: 2017-02-25 Impact factor: 4.256
Authors: Nicole C Wright; Kenneth G Saag; Jeffrey R Curtis; Wilson K Smith; Meredith L Kilgore; Michael A Morrisey; Huifeng Yun; Jie Zhang; Elizabeth S Delzell Journal: J Bone Miner Res Date: 2012-11 Impact factor: 6.741
Authors: Shuman Yang; William D Leslie; Lin Yan; Randy Walld; Leslie L Roos; Suzanne N Morin; Sumit R Majumdar; Lisa M Lix Journal: J Bone Miner Res Date: 2016-04-30 Impact factor: 6.741
Authors: J Pepe; G Della Grotta; R Santori; V De Martino; M Occhiuto; M Cilli; S Minisola; C Cipriani Journal: J Endocrinol Invest Date: 2021-02-12 Impact factor: 4.256
Authors: Anna Maria Formenti; Erika Pedone; Luigi di Filippo; Fabio Massimo Ulivieri; Andrea Giustina Journal: Endocrine Date: 2020-09-20 Impact factor: 3.925