Seyed Mohammad Mahdi Abtahi1, Seyed Mahmoud Reza Aghamiri2, Masoumeh Yadolahi3, Aziz Mahmoudzadeh4. 1. Physics Department, Imam Khomeini International University, Norouzian, P.O. Box 34148-96818, Qazvin, Iran. 2. Radiation Medicine Department, University of Shahid Beheshti, Tehran, Iran. 3. Nursing Care Research Center, Semnan University of Medical Sciences, Semnan, Iran. 4. Department of Bioscience and Biotechnology, Malek-Ashtar University of Technology, Tehran, Iran.
Abstract
AIM: The purpose of the present study is to investigate the dependence of micronuclei response on the depth of absorbed dose. BACKGROUND: One of the most common cytogenetic methods used for radiation dosimetry is micronuclei (MN). Being less complex and faster than other methods are two remarkable advantages of the MN method which make it suitable for monitoring of population. In biological dosimetry based on the micronuclei method, the investigation into the dependence of response on the depth in which dose is absorbed is significant, though has received less attention so far. MATERIALS AND METHODS: Blood samples were poured in separate vials to be irradiated at different depths using a linear accelerator system. RESULTS: According to the results, MN, as a function of the absorbed dose, had the best fitness with the linear-quadratic model at all depths. Furthermore, the results showed the dependence of MN response on the depth of absorbed dose. For doses up to 2 Gy, the maximum difference from the reference depth of 1.5 cm was related to the depth of 10 cm; however, by increasing the absorbed dose, the response associated with the depth of 20 cm showed the maximum deviation from the reference depth. CONCLUSIONS: Consequently, it is necessary to apply a correction factor to the biological dosimetry. The correction factor is dependent on the depth and the absorbed dose.
AIM: The purpose of the present study is to investigate the dependence of micronuclei response on the depth of absorbed dose. BACKGROUND: One of the most common cytogenetic methods used for radiation dosimetry is micronuclei (MN). Being less complex and faster than other methods are two remarkable advantages of the MN method which make it suitable for monitoring of population. In biological dosimetry based on the micronuclei method, the investigation into the dependence of response on the depth in which dose is absorbed is significant, though has received less attention so far. MATERIALS AND METHODS: Blood samples were poured in separate vials to be irradiated at different depths using a linear accelerator system. RESULTS: According to the results, MN, as a function of the absorbed dose, had the best fitness with the linear-quadratic model at all depths. Furthermore, the results showed the dependence of MN response on the depth of absorbed dose. For doses up to 2 Gy, the maximum difference from the reference depth of 1.5 cm was related to the depth of 10 cm; however, by increasing the absorbed dose, the response associated with the depth of 20 cm showed the maximum deviation from the reference depth. CONCLUSIONS: Consequently, it is necessary to apply a correction factor to the biological dosimetry. The correction factor is dependent on the depth and the absorbed dose.
Authors: P Venkatachalam; F D Solomon; B K Prabhu; M N Mohankumar; N Gajendiran; R K Jeevanram Journal: Mutat Res Date: 1999-08-11 Impact factor: 2.433
Authors: Alicia Marín; Margarita Martín; Olga Liñán; Felipe Alvarenga; Mario López; Laura Fernández; David Büchser; Laura Cerezo Journal: Rep Pract Oncol Radiother Date: 2014-08-28
Authors: Urszula Kaźmierczak; Dariusz Banaś; Janusz Braziewicz; Iwona Buraczewska; Joanna Czub; Marian Jaskóła; Łukasz Kaźmierczak; Andrzej Korman; Marcin Kruszewski; Anna Lankoff; Halina Lisowska; Marta Nesteruk; Zygmunt Szefliński; Maria Wojewódzka Journal: Rep Pract Oncol Radiother Date: 2014-05-19
Authors: R J Albertini; D Anderson; G R Douglas; L Hagmar; K Hemminki; F Merlo; A T Natarajan; H Norppa; D E Shuker; R Tice; M D Waters; A Aitio Journal: Mutat Res Date: 2000-08 Impact factor: 2.433