Angela C Garinis1,2, Alison Kemph3, Anne Marie Tharpe3, Joern-Hendrik Weitkamp4, Cynthia McEvoy5, Peter S Steyger1,2. 1. a Oregon Hearing Research Center, Otolaryngology , Oregon Health & Science University , Portland , OR , USA. 2. b National Center for Rehabilitative Auditory Research , VA Portland Health Care System , Portland , OR , USA. 3. c Hearing and Speech Sciences , Vanderbilt University School of Medicine , Nashville , TN , USA. 4. d Pediatrics , Vanderbilt University School of Medicine , Nashville , TN , USA , and. 5. e Neonatology, Pediatrics , Oregon Health & Science University , Portland , OR , USA.
Abstract
OBJECTIVES: Neonates admitted to the neonatal intensive care unit (NICU) are at greater risk of permanent hearing loss compared to infants in well mother and baby units. Several factors have been associated with this increased prevalence of hearing loss, including congenital infections (e.g. cytomegalovirus or syphilis), ototoxic drugs (such as aminoglycoside or glycopeptide antibiotics), low birth weight, hypoxia and length of stay. The aetiology of this increased prevalence of hearing loss remains poorly understood. DESIGN: Here we review current practice and discuss the feasibility of designing improved ototoxicity screening and monitoring protocols to better identify acquired, drug-induced hearing loss in NICU neonates. STUDY SAMPLE: A review of published literature. CONCLUSIONS: We conclude that current audiological screening or monitoring protocols for neonates are not designed to adequately detect early onset of ototoxicity. This paper offers a detailed review of evidence-based research, and offers recommendations for developing and implementing an ototoxicity monitoring protocol for young infants, before and after discharge from the hospital.
OBJECTIVES: Neonates admitted to the neonatal intensive care unit (NICU) are at greater risk of permanent hearing loss compared to infants in well mother and baby units. Several factors have been associated with this increased prevalence of hearing loss, including congenital infections (e.g. cytomegalovirus or syphilis), ototoxic drugs (such as aminoglycoside or glycopeptide antibiotics), low birth weight, hypoxia and length of stay. The aetiology of this increased prevalence of hearing loss remains poorly understood. DESIGN: Here we review current practice and discuss the feasibility of designing improved ototoxicity screening and monitoring protocols to better identify acquired, drug-induced hearing loss in NICU neonates. STUDY SAMPLE: A review of published literature. CONCLUSIONS: We conclude that current audiological screening or monitoring protocols for neonates are not designed to adequately detect early onset of ototoxicity. This paper offers a detailed review of evidence-based research, and offers recommendations for developing and implementing an ototoxicity monitoring protocol for young infants, before and after discharge from the hospital.
Entities:
Keywords:
Newborn hearing screening; anatomy and physiology; conditions/pathology/disorders; paediatric
Authors: Penelope R Brock; Kristin R Knight; David R Freyer; Kathleen C M Campbell; Peter S Steyger; Brian W Blakley; Shahrad R Rassekh; Kay W Chang; Brian J Fligor; Kaukab Rajput; Michael Sullivan; Edward A Neuwelt Journal: J Clin Oncol Date: 2012-04-30 Impact factor: 44.544
Authors: Matthew M Laughon; Kim Chantala; Sofia Aliaga; Amy H Herring; Christoph P Hornik; Rachel Hughes; Reese H Clark; P Brian Smith Journal: Am J Perinatol Date: 2014-05-06 Impact factor: 3.079