BACKGROUND AND AIMS: Emerging evidence shows that fibroblast growth factor 22 (FGF22) plays a critical role in the etiology of depression. However, the molecular mechanisms of FGF22 are not fully comprehended. Here, the effect of FGF22 in depression and its relationship with interleukin-1β (IL-1β) were investigated in clinical, animal, and cell experiments. METHODS: Serum from depressive patients was collected, and the levels of FGF22 and IL-1β were analyzed by ELISA. The chronic unpredictable mild stress (CUMS) model was established, and primary hippocampal neuronal cells were cultured to examine changes in FGF22 and IL-1β levels in rat hippocampus. RESULTS: The results revealed a negative correlation between serum FGF22 levels and serum IL-1β levels. The expression of IL-1β in the CUMS rat hippocampus decreased, and the apoptosis of hippocampal cells improved after the injection of lentiviral vector-mediated FGF22 (LV-FGF22). Further tests in primary hippocampal neuronal cells also showed a reduction in IL-1β and the cell apoptosis rate after treatment with FGF22. CONCLUSION: In conclusion, the results revealed that FGF22 plays a role in alleviating depression, which may be mediated by reduced expression of IL-1β.
BACKGROUND AND AIMS: Emerging evidence shows that fibroblast growth factor 22 (FGF22) plays a critical role in the etiology of depression. However, the molecular mechanisms of FGF22 are not fully comprehended. Here, the effect of FGF22 in depression and its relationship with interleukin-1β (IL-1β) were investigated in clinical, animal, and cell experiments. METHODS: Serum from depressivepatients was collected, and the levels of FGF22 and IL-1β were analyzed by ELISA. The chronic unpredictable mild stress (CUMS) model was established, and primary hippocampal neuronal cells were cultured to examine changes in FGF22 and IL-1β levels in rat hippocampus. RESULTS: The results revealed a negative correlation between serum FGF22 levels and serum IL-1β levels. The expression of IL-1β in the CUMS rat hippocampus decreased, and the apoptosis of hippocampal cells improved after the injection of lentiviral vector-mediated FGF22 (LV-FGF22). Further tests in primary hippocampal neuronal cells also showed a reduction in IL-1β and the cell apoptosis rate after treatment with FGF22. CONCLUSION: In conclusion, the results revealed that FGF22 plays a role in alleviating depression, which may be mediated by reduced expression of IL-1β.
Authors: Elyse L Aurbach; Edny Gula Inui; Cortney A Turner; Megan H Hagenauer; Katherine E Prater; Jun Z Li; Devin Absher; Najmul Shah; Peter Blandino; William E Bunney; Richard M Myers; Jack D Barchas; Alan F Schatzberg; Stanley J Watson; Huda Akil Journal: Proc Natl Acad Sci U S A Date: 2015-09-08 Impact factor: 11.205
Authors: A Knedla; B Riepl; S Lefèvre; S Kistella; J Grifka; R H Straub; S Gay; J Schölmerich; U Müller-Ladner; E Neumann Journal: Ann Rheum Dis Date: 2008-03-13 Impact factor: 19.103
Authors: A Vezzani; D Moneta; M Conti; C Richichi; T Ravizza; A De Luigi; M G De Simoni; G Sperk; S Andell-Jonsson; J Lundkvist; K Iverfeldt; T Bartfai Journal: Proc Natl Acad Sci U S A Date: 2000-10-10 Impact factor: 11.205