Aviane Auguste1,2, Stanie Gaëte3, Cécile Herrmann-Storck4, Leah Michineau1,2, Clarisse Joachim5, Jacqueline Deloumeaux3,6, Suzy Duflo7, Danièle Luce8,9,10. 1. INSERM U 1085 - IRSET (Research Institute for Environmental and Occupational Health), Pointe-à-Pitre, Guadeloupe, France. 2. University of Rennes 1, Rennes, France. 3. Centre de Ressources Biologiques de Guadeloupe, Pointe-à-Pitre, Guadeloupe, France. 4. Laboratory of Microbiology, University Hospital of Guadeloupe, Pointe-à-Pitre, Guadeloupe, France. 5. Martinique Cancer Registry, UF 1441 Registre des cancers, Pôle de Cancérologie Hématologie Urologie Pathologie, University Hospital of Martinique, Fort-de-France, Martinique, France. 6. General Cancer Registry of Guadeloupe, University Hospital of Guadeloupe, Pointe-à-Pitre, Guadeloupe, France. 7. Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Hospital of Guadeloupe, Pointe-à-Pitre, Guadeloupe, France. 8. INSERM U 1085 - IRSET (Research Institute for Environmental and Occupational Health), Pointe-à-Pitre, Guadeloupe, France. daniele.luce@inserm.fr. 9. University of Rennes 1, Rennes, France. daniele.luce@inserm.fr. 10. INSERM U 1085 - IRSET, Faculté de Médecine, Campus de Fouillole, BP 145, 97154, Pointe-à-Pitre, France. daniele.luce@inserm.fr.
Abstract
PURPOSE: Human papillomavirus (HPV) is known to play a role in the development of head and neck squamous cell carcinomas (HNSCC) and to date, no study has reported on the association between oral HPV infection and HNSCC in the Caribbean. The objective was to determine the prevalence of oral HPV infection in the French West Indies (FWI), overall and by HPV genotype, among HNSCC cases and healthy population controls. METHOD: We used data from a population-based case-control study conducted in the FWI. The prevalence of oral HPV was estimated separately among 100 HNSCC cases (mean age 59 years) and 308 population controls (mean age 57 years). Odds ratios (OR) and 95% confidence intervals (CI) were estimated using a logistic regression adjusting for age, sex, tobacco, and alcohol consumption, to assess the association between oral HPV infection and HNSCC. RESULTS: Prevalence of oral HPV infections was 26% in controls (30% in men and 14% in women) and 36% in HNSCC cases (36% in men, 33% in women). HPV52 was the most commonly detected genotype, in cases and in controls. The prevalence of HPV16, HPV33, and HPV51 was significantly higher in cases than in controls (p = 0.0340, p = 0.0472, and 0.0144, respectively). Oral infection with high-risk HPV was associated with an increase in risk of HNSCC (OR 1.99, 95% CI 0.95-4.15). HPV16 was only associated with oropharyngeal cancer (OR 16.01, 95% CI 1.67-153.64). CONCLUSION: This study revealed a high prevalence of oral HPV infection in this middle-aged Afro-Caribbean population, and a specific distribution of HPV genotypes. These findings may provide insight into HNSCC etiology specific to the FWI.
PURPOSE:Human papillomavirus (HPV) is known to play a role in the development of head and neck squamous cell carcinomas (HNSCC) and to date, no study has reported on the association between oral HPV infection and HNSCC in the Caribbean. The objective was to determine the prevalence of oral HPV infection in the French West Indies (FWI), overall and by HPV genotype, among HNSCC cases and healthy population controls. METHOD: We used data from a population-based case-control study conducted in the FWI. The prevalence of oral HPV was estimated separately among 100 HNSCC cases (mean age 59 years) and 308 population controls (mean age 57 years). Odds ratios (OR) and 95% confidence intervals (CI) were estimated using a logistic regression adjusting for age, sex, tobacco, and alcohol consumption, to assess the association between oral HPV infection and HNSCC. RESULTS: Prevalence of oral HPV infections was 26% in controls (30% in men and 14% in women) and 36% in HNSCC cases (36% in men, 33% in women). HPV52 was the most commonly detected genotype, in cases and in controls. The prevalence of HPV16, HPV33, and HPV51 was significantly higher in cases than in controls (p = 0.0340, p = 0.0472, and 0.0144, respectively). Oral infection with high-risk HPV was associated with an increase in risk of HNSCC (OR 1.99, 95% CI 0.95-4.15). HPV16 was only associated with oropharyngeal cancer (OR 16.01, 95% CI 1.67-153.64). CONCLUSION: This study revealed a high prevalence of oral HPV infection in this middle-aged Afro-Caribbean population, and a specific distribution of HPV genotypes. These findings may provide insight into HNSCC etiology specific to the FWI.
Entities:
Keywords:
Caribbean; France; Head and neck cancer; Human papillomavirus; Oral HPV; Saliva samples
Authors: Óscar Rapado-González; Cristina Martínez-Reglero; Ángel Salgado-Barreira; Almudena Rodríguez-Fernández; Santiago Aguín-Losada; Luis León-Mateos; Laura Muinelo-Romay; Rafael López-López; María Mercedes Suarez-Cunqueiro Journal: J Clin Med Date: 2020-05-01 Impact factor: 4.241