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Literature DB >> 28948156

Short poly-glutamine repeat in the androgen receptor in New World monkeys.

Chihiro Hiramatsu^1,2, Annika Paukner³, Hika Kuroshima⁴, Kazuo Fujita⁴, Stephen J Suomi³, Miho Inoue-Murayama^5,6.

Abstract

The androgen receptor mediates various physiological and developmental functions and is highly conserved in mammals. Although great intraspecific length polymorphisms in poly glutamine (poly-Q) and poly glycine (poly-G) regions of the androgen receptor in humans, apes and several Old World monkeys have been reported, little is known about the characteristics of these regions in New World monkeys. In this study, we surveyed 17 species of New World monkeys and found length polymorphisms in these regions in three species (common squirrel monkeys, tufted capuchin monkeys and owl monkeys). We found that the poly-Q region in New World monkeys is relatively shorter than that in catarrhines (humans, apes and Old World monkeys). In addition, we observed that codon usage for poly-G region in New World monkeys is unique among primates. These results suggest that the length of polymorphic regions in androgen receptor genes have evolved uniquely in New World monkeys.

Entities: Chemical Disease Gene Species

Keywords: Androgen receptor; Microsatellite repeat; New World monkey; Polymorphism

Year: 2017 PMID： 28948156 PMCID： PMC5609184 DOI： 10.1016/j.mgene.2017.08.006

Source DB: PubMed Journal: Meta Gene ISSN： 2214-5400

30 in total

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Authors: Céline Poux; Ole Madsen; Elisabeth Marquard; David R Vieites; Wilfried W de Jong; Miguel Vences
Journal: Syst Biol Date: 2005-10 Impact factor: 15.683

Review 2. Mechanism of androgen receptor action.

Authors: Jin Li; Farook Al-Azzawi
Journal: Maturitas Date: 2009-04-15 Impact factor: 4.342

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Authors: E G Jönsson; C von Gertten; J P Gustavsson; Q P Yuan; K Lindblad-Toh; K Forslund; G Rylander; M Mattila-Evenden; M Asberg; M Schalling
Journal: Psychiatr Genet Date: 2001-03 Impact factor: 2.458

4. Codon repeats in genes associated with human diseases: fewer repeats in the genes of nonhuman primates and nucleotide substitutions concentrated at the sites of reiteration.

Authors: P Djian; J M Hancock; H S Chana
Journal: Proc Natl Acad Sci U S A Date: 1996-01-09 Impact factor: 11.205

5. Evolution of the primate androgen receptor: a structural basis for disease.

Authors: C S Choong; J A Kemppainen; E M Wilson
Journal: J Mol Evol Date: 1998-09 Impact factor: 2.395

6. Androgen receptor CAG repeat polymorphism in males of six non-human primate species.

Authors: James N Mubiru; Nicole Cavazos; Peggah Hemmat; Magdalena Garcia-Forey; Robert E Shade; Jeffrey Rogers
Journal: J Med Primatol Date: 2011-10-07 Impact factor: 0.667

Review 7. Phenotypic heterogeneity of mutations in androgen receptor gene.

Authors: Singh Rajender; Lalji Singh; Kumarasamy Thangaraj
Journal: Asian J Androl Date: 2007-03 Impact factor: 3.285

8. Increased estrogen rather than decreased androgen action is associated with longer androgen receptor CAG repeats.

Authors: Ilpo T Huhtaniemi; Stephen R Pye; Kate L Limer; Wendy Thomson; Terence W O'Neill; Hazel Platt; Debbie Payne; Sally L John; Min Jiang; Steven Boonen; Herman Borghs; Dirk Vanderschueren; Judith E Adams; Kate A Ward; György Bartfai; Felipe Casanueva; Joseph D Finn; Gianni Forti; Aleksander Giwercman; Thang S Han; Krzysztof Kula; Michael E J Lean; Neil Pendleton; Margus Punab; Alan J Silman; Frederick C W Wu
Journal: J Clin Endocrinol Metab Date: 2008-10-07 Impact factor: 5.958