Literature DB >> 28945472

Immune Tolerance, Xenografts, and Large-Animal Studies in Transplantation.

David H Sachs1.   

Abstract

This article summarizes studies in which the author has been involved over several decades, directed toward providing solutions for the three major limitations to the field of transplantation: (1) drug treatment-related complications; (2) chronic rejection; and (3) the availability of transplantable organs. The first two of these limitations may be overcome by induction of transplantation tolerance, while the third will also require a new source of organs, for which great strides are now being made in xenotransplantation through genetic engineering.

Keywords:  tolerance; transplantation; xenotransplantation

Mesh：

Year:  2017        PMID： 28945472      PMCID： PMC5711340          DOI： 10.1513/AnnalsATS.201607-534MG

Source DB:  PubMed          Journal:  Ann Am Thorac Soc        ISSN： 2325-6621


  34 in total

Review 1.  Induction of tolerance through mixed chimerism.

Authors:  David H Sachs; Tatsuo Kawai; Megan Sykes
Journal:  Cold Spring Harb Perspect Med       Date:  2014-01-01       Impact factor: 6.915

2.  HLA-mismatched renal transplantation without maintenance immunosuppression.

Authors:  Tatsuo Kawai; David H Sachs; Megan Sykes; A Benedict Cosimi
Journal:  N Engl J Med       Date:  2013-05-09       Impact factor: 91.245

3.  Identification of carbohydrate structures that bind human antiporcine antibodies: implications for discordant xenografting in humans.

Authors:  A H Good; D K Cooper; A J Malcolm; R M Ippolito; E Koren; F A Neethling; Y Ye; N Zuhdi; L R Lamontagne
Journal:  Transplant Proc       Date:  1992-04       Impact factor: 1.066

4.  Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease.

Authors:  Leo H Bühler; Thomas R Spitzer; Megan Sykes; David H Sachs; Francis L Delmonico; Nina Tolkoff-Rubin; Susan L Saidman; Robert Sackstein; Steven McAfee; Bimalangshu Dey; Christine Colby; A Benedict Cosimi
Journal:  Transplantation       Date:  2002-11-27       Impact factor: 4.939

5.  Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism.

Authors:  T R Spitzer; F Delmonico; N Tolkoff-Rubin; S McAfee; R Sackstein; S Saidman; C Colby; M Sykes; D H Sachs; A B Cosimi
Journal:  Transplantation       Date:  1999-08-27       Impact factor: 4.939

6.  Long-term outcome and alloantibody production in a non-myeloablative regimen for induction of renal allograft tolerance.

Authors:  T Kawai; A Poncelet; D H Sachs; S Mauiyyedi; S Boskovic; S L Wee; D S Ko; A Bartholomew; M Kimikawa; H Z Hong; G Abrahamian; R B Colvin; A B Cosimi
Journal:  Transplantation       Date:  1999-12-15       Impact factor: 4.939

7.  Mixed chimerism and tolerance without whole body irradiation in a large animal model.

Authors:  Y Fuchimoto; C A Huang; K Yamada; A Shimizu; H Kitamura; R B Colvin; V Ferrara; M C Murphy; M Sykes; M White-Scharf; D M Neville; D H Sachs
Journal:  J Clin Invest       Date:  2000-06       Impact factor: 14.808

8.  HLA-mismatched renal transplantation without maintenance immunosuppression.

Authors:  Tatsuo Kawai; A Benedict Cosimi; Thomas R Spitzer; Nina Tolkoff-Rubin; Manikkam Suthanthiran; Susan L Saidman; Juanita Shaffer; Frederic I Preffer; Ruchuang Ding; Vijay Sharma; Jay A Fishman; Bimalangshu Dey; Dicken S C Ko; Martin Hertl; Nelson B Goes; Waichi Wong; Winfred W Williams; Robert B Colvin; Megan Sykes; David H Sachs
Journal:  N Engl J Med       Date:  2008-01-24       Impact factor: 91.245

9.  Production of alpha 1,3-galactosyltransferase-deficient pigs.

Authors:  Carol J Phelps; Chihiro Koike; Todd D Vaught; Jeremy Boone; Kevin D Wells; Shu-Hung Chen; Suyapa Ball; Susan M Specht; Irina A Polejaeva; Jeff A Monahan; Pete M Jobst; Sugandha B Sharma; Ashley E Lamborn; Amy S Garst; Marilyn Moore; Anthony J Demetris; William A Rudert; Rita Bottino; Suzanne Bertera; Massimo Trucco; Thomas E Starzl; Yifan Dai; David L Ayares
Journal:  Science       Date:  2002-12-19       Impact factor: 47.728

10.  Results of life-supporting galactosyltransferase knockout kidneys in cynomolgus monkeys using two different sources of galactosyltransferase knockout Swine.

Authors:  Mitsuhiro Sekijima; Shiori Waki; Hisashi Sahara; Masayuki Tasaki; Robert A Wilkinson; Vincenzo Villani; Yoshiki Shimatsu; Kazuaki Nakano; Hitomi Matsunari; Hiroshi Nagashima; Jay A Fishman; Akira Shimizu; Kazuhiko Yamada
Journal:  Transplantation       Date:  2014-08-27       Impact factor: 4.939
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  3 in total

Review 1.  Transplanting organs from pigs to humans.

Authors:  Megan Sykes; David H Sachs
Journal:  Sci Immunol       Date:  2019-11-01

2.  Single xenotransplant of rat brown adipose tissue prolonged the ovarian lifespan of aging mice by improving follicle survival.

Authors:  Liang-Jian Chen; Zhi-Xia Yang; Yang Wang; Lei Du; Yan-Ru Li; Na-Na Zhang; Wen-Yi Gao; Rui-Rui Peng; Feng-Yu Zhu; Li-Li Wang; Cong-Rong Li; Jian-Min Li; Fu-Qiang Wang; Qing-Yuan Sun; Dong Zhang
Journal:  Aging Cell       Date:  2019-08-06       Impact factor: 9.304

3.  IL-27 Rα+ cells promoted allorejection via enhancing STAT1/3/5 phosphorylation.

Authors:  Shanshan Zhao; Ting Liang; Chao Zhang; Dai Shi; Wen Jiang; Chen Su; Guihua Hou
Journal:  J Cell Mol Med       Date:  2020-08-06       Impact factor: 5.310
  3 in total

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