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Literature DB >> 28943028

Engineering Ethics and Self-Organizing Models of Human Development: Opportunities and Challenges.

Abstract

Incorporating engineering ethics early during the planning stages of organoid and gastruloid research may help prevent future confusion about the moral status of complex models of human development. However, the intrinsic self-organizing behavior of organoids and gastruloids may pose a slight challenge to this novel ethical approach.

Entities: Species

Mesh：

Year: 2017 PMID： 28943028 DOI： 10.1016/j.stem.2017.09.002

Source DB: PubMed Journal: Cell Stem Cell ISSN： 1875-9777 Impact factor: 24.633

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Cited

7 in total

1. The moral status of human embryo-like structures: potentiality matters?: The moral status of human synthetic embryos.

Authors: Tsutomu Sawai; Tomohiro Minakawa; Jonathan Pugh; Kyoko Akatsuka; Jun K Yamashita; Misao Fujita
Journal: EMBO Rep Date: 2020-07-27 Impact factor: 8.807

2. Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells.

Authors: Yusuke Marikawa; Hong-Ru Chen; Mark Menor; Youping Deng; Vernadeth B Alarcon
Journal: Reprod Toxicol Date: 2019-11-08 Impact factor: 3.143

Review 3. Organoids in Tissue Transplantation.

Authors: Derya Sağraç; Hatice Burcu Şişli; Selinay Şenkal; Taha Bartu Hayal; Fikrettin Şahin; Ayşegül Doğan
Journal: Adv Exp Med Biol Date: 2021 Impact factor: 2.622

Review 4. Patient derived stem cells for discovery and validation of novel pathogenic variants in inherited retinal disease.

Authors: Nathaniel K Mullin; Andrew P Voigt; Jessica A Cooke; Laura R Bohrer; Erin R Burnight; Edwin M Stone; Robert F Mullins; Budd A Tucker
Journal: Prog Retin Eye Res Date: 2020-10-29 Impact factor: 21.198

Engineering Ethics and Self-Organizing Models of Human Development: Opportunities and Challenges.

1. The moral status of human embryo-like structures: potentiality matters?: The moral status of human synthetic embryos.

2. Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells.

Review 3. Organoids in Tissue Transplantation.

Review 4. Patient derived stem cells for discovery and validation of novel pathogenic variants in inherited retinal disease.

5. Creation and use of organoids in biomedical research and healthcare: the bioethical and metabioethical issues.

Review 6. Organoids: a systematic review of ethical issues.

7. Patients' perspectives on the derivation and use of organoids.