Patel Mahipal1, Rajesh Singh Pawar2. 1. Pharmacognosy, Phytochemistry, & Ethnophamacology Laboratory, VNS Group of Institution, Faculty of Pharmacy, VNS Campus, Vidya Vihar, Neelbud, Bhopal, Madhya Pradesh, 462044, India. 2. Pharmacognosy, Phytochemistry, & Ethnophamacology Laboratory, VNS Group of Institution, Faculty of Pharmacy, VNS Campus, Vidya Vihar, Neelbud, Bhopal, Madhya Pradesh, 462044, India. Electronic address: dr_pawar14@rediffmail.com.
Abstract
OBJECTIVE: To evaluate the nephroprotective effect of defatted methanolic extract and aqueous extract of Murraya koenigii (M. koenigii) against cyclophosphamide drug. METHODS: Nephrotoxicity was induced by cyclophosphamide in 7 days at 150 mg/kg body weight through intraperitoneal route in rat model. Nephroprotective activity of M. koenigii extract (100 mg/kg and 200 mg/kg in intraperitoneal route) was measured, including nephrological source, oxidative stress parameters like superoxide dismutase, glutathione, the lipid peroxide and in vivo assay like blood urea nitrogen, creatinine were determined and analyzed by One way analysis of variance followed by Tukey's test. RESULTS: The study result showed that important phytochemicals such as carbohydrates, flavonoids, tannin, alkaloids, glycosides, protein and steroids were found to be present in the extract of M. koenigii. The renal function markers like blood urea nitrogen and creatinine level were found to be decreased significantly by M. koenigii extract treatment. A significant difference was found to be at P < 0.01. CONCLUSIONS: The present study reveals the protective role of M. koenigii extract against cyclophosphamide induced nephrotoxicity.
OBJECTIVE: To evaluate the nephroprotective effect of defatted methanolic extract and aqueous extract of Murraya koenigii (M. koenigii) against cyclophosphamide drug. METHODS:Nephrotoxicity was induced by cyclophosphamide in 7 days at 150 mg/kg body weight through intraperitoneal route in rat model. Nephroprotective activity of M. koenigii extract (100 mg/kg and 200 mg/kg in intraperitoneal route) was measured, including nephrological source, oxidative stress parameters like superoxide dismutase, glutathione, the lipid peroxide and in vivo assay like blood ureanitrogen, creatinine were determined and analyzed by One way analysis of variance followed by Tukey's test. RESULTS: The study result showed that important phytochemicals such as carbohydrates, flavonoids, tannin, alkaloids, glycosides, protein and steroids were found to be present in the extract of M. koenigii. The renal function markers like blood ureanitrogen and creatinine level were found to be decreased significantly by M. koenigii extract treatment. A significant difference was found to be at P < 0.01. CONCLUSIONS: The present study reveals the protective role of M. koenigii extract against cyclophosphamide induced nephrotoxicity.
Authors: Maha I Alkhalaf; Wafa S Alansari; Fawzia A Alshubaily; Afnan M Alnajeebi; Areej A Eskandrani; Manal A Tashkandi; Nouf A Babteen Journal: Sci Rep Date: 2020-07-28 Impact factor: 4.379
Authors: Adel M Ahmad; Hamdoon A Mohammed; Tarek M Faris; Abeer S Hassan; Hebatallah B Mohamed; Mahmoud I El Dosoky; Esam M Aboubakr Journal: Molecules Date: 2021-12-10 Impact factor: 4.411