Constantin Tuleasca1,2,3, Tatiana Witjas4,5, Elena Najdenovska6, Antoine Verger7, Nadine Girard8, Jerome Champoudry9, Jean-Philippe Thiran10,11, Dimitri Van de Ville12,13, Meritxell Bach Cuadra6, Marc Levivier14,11, Eric Guedj7, Jean Régis9. 1. Neurosurgery Service and Gamma Knife Center, Centre Hospitalier Universitaire Vaudois (CHUV), Rue du Bugnon 44-46, BH-08, CH-1011, Lausanne, Switzerland. constantin.tuleasca@gmail.com. 2. Signal Processing Laboratory (LTS 5), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. constantin.tuleasca@gmail.com. 3. Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland. constantin.tuleasca@gmail.com. 4. Department of Neurology and Movement Disorders, Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital, Marseille, France. 5. Institut de Neurosciences de la Timone, UMR 7289, CNRS Aix-Marseille Université, Marseille, France. 6. Radiology Department, Center for Biomedical Imaging (CIBM), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. 7. Department of Nuclear Medicine, Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Timone University Hospital, France;Institut de Neurosciences de la Timone, UMR 7289, CNRS Aix-Marseille Université, CERIMED, Aix-Marseille Université, Marseille, France. 8. Department of Diagnostic and Interventionnal Neuroradiology, AMU, CRMBM UMR CNRS 7339, Faculté de Médecine et APHM, Hopital Timone, Marseille, France. 9. Stereotactic and Functional Neurosurgery Service and Gamma Knife Unit, CHU Timone, Marseille, France. 10. Signal Processing Laboratory (LTS 5), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. 11. Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland. 12. Medical Image Processing Laboratory, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. 13. Faculty of Medicine, University of Geneva, Geneva, Switzerland. 14. Neurosurgery Service and Gamma Knife Center, Centre Hospitalier Universitaire Vaudois (CHUV), Rue du Bugnon 44-46, BH-08, CH-1011, Lausanne, Switzerland.
Abstract
INTRODUCTION: Radiosurgery (RS) is an alternative to open standard stereotactic procedures (deep-brain stimulation or radiofrequency thalamotomy) for drug-resistant essential tremor (ET), aiming at the same target (ventro-intermediate nucleus, Vim). We investigated the Vim RS outcome using voxel-based morphometry by evaluating the interaction between clinical response and time. METHODS: Thirty-eight patients with right-sided ET benefited from left unilateral Vim RS. Targeting was performed using 130 Gy and a single 4-mm collimator. Neurological and neuroimaging assessment was completed at baseline and 1 year. Clinical responders were considered those with at least 50% improvement in tremor score on the treated hand (TSTH). RESULTS: Interaction between clinical response and time showed the left temporal pole and occipital cortex (Brodmann area 19, including V4, V5 and the parahippocampal place area) as statistically significant. A decrease in gray matter density (GMD) 1 year after Vim RS correlated with higher TSTH improvement (Spearman = 0.01) for both anatomical areas. Higher baseline GMD within the left temporal pole correlated with better TSTH improvement (Spearman = 0.004). CONCLUSIONS: Statistically significant structural changes in the relationship to clinical response after Vim RS are present in remote areas, advocating a distant neurobiological effect. The former regions are mainly involved in locomotor monitoring toward the local and distant environment, suggesting the recruiting requirement in targeting of the specific visuomotor networks.
INTRODUCTION: Radiosurgery (RS) is an alternative to open standard stereotactic procedures (deep-brain stimulation or radiofrequency thalamotomy) for drug-resistant essential tremor (ET), aiming at the same target (ventro-intermediate nucleus, Vim). We investigated the Vim RS outcome using voxel-based morphometry by evaluating the interaction between clinical response and time. METHODS: Thirty-eight patients with right-sided ET benefited from left unilateral Vim RS. Targeting was performed using 130 Gy and a single 4-mm collimator. Neurological and neuroimaging assessment was completed at baseline and 1 year. Clinical responders were considered those with at least 50% improvement in tremor score on the treated hand (TSTH). RESULTS: Interaction between clinical response and time showed the left temporal pole and occipital cortex (Brodmann area 19, including V4, V5 and the parahippocampal place area) as statistically significant. A decrease in gray matter density (GMD) 1 year after Vim RS correlated with higher TSTH improvement (Spearman = 0.01) for both anatomical areas. Higher baseline GMD within the left temporal pole correlated with better TSTH improvement (Spearman = 0.004). CONCLUSIONS: Statistically significant structural changes in the relationship to clinical response after Vim RS are present in remote areas, advocating a distant neurobiological effect. The former regions are mainly involved in locomotor monitoring toward the local and distant environment, suggesting the recruiting requirement in targeting of the specific visuomotor networks.
Authors: Derek B Archer; Stephen A Coombes; Winston T Chu; Jae Woo Chung; Roxana G Burciu; Michael S Okun; Aparna Wagle Shukla; David E Vaillancourt Journal: Brain Date: 2018-06-01 Impact factor: 13.501
Authors: Derek B Archer; Stephen A Coombes; Winston T Chu; Jae Woo Chung; Roxana G Burciu; Michael S Okun; Aparna Wagle Shukla; David E Vaillancourt Journal: Brain Date: 2018-02-01 Impact factor: 13.501
Authors: Thomas A W Bolton; Dimitri Van De Ville; Jean Régis; Tatiana Witjas; Nadine Girard; Marc Levivier; Constantin Tuleasca Journal: Front Aging Neurosci Date: 2022-05-23 Impact factor: 5.702
Authors: Elena Najdenovska; Constantin Tuleasca; João Jorge; Philippe Maeder; José P Marques; Timo Roine; Daniel Gallichan; Jean-Philippe Thiran; Marc Levivier; Meritxell Bach Cuadra Journal: Sci Rep Date: 2019-02-04 Impact factor: 4.379
Authors: Constantin Tuleasca; Thomas Bolton; Jean Régis; Tatiana Witjas; Nadine Girard; Marc Levivier; Dimitri Van De Ville Journal: Hum Brain Mapp Date: 2019-12-15 Impact factor: 5.038
Authors: Gilles Allali; Helena M Blumen; Hervé Devanne; Elvira Pirondini; Arnaud Delval; Dimitri Van De Ville Journal: Neurophysiol Clin Date: 2018-10-25 Impact factor: 3.734
Authors: Hongmei Cao; Rong Wang; Xue Luo; Xianjun Li; Mark Hallett; Johanna Thompson-Westra; Jian Yang; Qiumin Qu; Xiaobo Yang Journal: Med Sci Monit Date: 2018-05-13
Authors: Robert Francis Dallapiazza; Darrin J Lee; Philippe De Vloo; Anton Fomenko; Clement Hamani; Mojgan Hodaie; Suneil K Kalia; Alfonso Fasano; Andres M Lozano Journal: J Neurol Neurosurg Psychiatry Date: 2018-10-18 Impact factor: 10.154