P Theut Riis1,2, D M Saunte1,2, F Benhadou3, V Del Marmol3, P Guillem4, M El-Domyati5, H Abdel-Wahab5, C Antoniou6, C Dessinioti6, M A Gürer7, B Beksaç7, J C Szepietowski8, L Matusiak8, L Emtestam9, J Lapins9, H Riad10, N Doss11, A F Massa12, I Hamzavi13, C Nicholson13, M Dolenc-Voljc14,15, K H Kim16,17, J Ohn16,17, C C Zouboulis18, I Karagiannidis18, Z B Mokos19, P Durinec19, G B E Jemec1,2. 1. Department of Dermatology, University Hospital Zealand, Roskilde, Denmark. 2. Health Sciences Faculty, University of Copenhagen, Copenhagen, Denmark. 3. Department of Dermatology, Hopital Erasme, Université Libre de Bruxelles, Bruxelles, Belgium. 4. Clinique du Val d'Ouest, Ecully, France. 5. Department of Dermatology, Minia University, Al-Minya, Egypt. 6. Department of Dermatology, Andreas Sygros Hospital, University of Athens, Athens, Greece. 7. Department of Dermatology, Faculty of Medicine, Gazi University, Ankara, Turkey. 8. Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland. 9. Unit of Infection and Dermatology, Department of Medicine, Huddinge at Karolinska Institutet, Stockholm, Sweden. 10. Hamad medical corporation, Doha, Quatar. 11. Department of Dermatology, Military Hospital of Tunis, University Tunis El Manar, Tunis, Tunisia. 12. Clínica Dermatológica, Porto, Portugal. 13. Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA. 14. Department of Dermatovenereology, University Medical Centre Ljubljana, Ljubljana, Slovenia. 15. Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. 16. Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea. 17. Institute of Human-Environment Interface Biology, Seoul National University College of Medicine, Seoul, Korea. 18. Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodore Fontane, Dessau, Germany. 19. Department of Dermatology and Venereology, University Hospital Center Zagreb and School of Medicine University of Zagreb, Zagreb, Croatia.
Abstract
INTRODUCTION: Overweight is a well-established risk factor for hidradenitis suppurativa (HS). In this cross-sectional study, we compare HS patients with a high body mass index (BMI) with HS patients with a low BMI to investigate differences in disease characteristics. MATERIALS AND METHOD: Patients were recruited from 17 dermatological centres from four continents. A total of 246 patients with a BMI below 25 were compared to 205 patients with a BMI of above 35. RESULTS: Patients with a high BMI suffered more severe disease (Hurley, physician global assessment, number of areas affected and patient-reported severity (PRS), P < 0.001 for all). There was no difference in smoking (P = 0.783) nor in family history (P = 0.088). In both low and high BMI patients, early onset of HS was a predictor of positive family history (P < 0.001, for each). For low BMI patients, an increase in BMI significantly increased PRS (P < 0.001). For patients with a high BMI, number of pack-years significantly increased PRS (P = 0.001). Cluster analysis of eruption patterns was location specific for low BMI patients but severity specific for high BMI patients. DISCUSSION: Patients with a low and high BMI could represent two clinically different subtypes. We suggest a non-linear relationship between BMI and impact of HS. As patients go from a low BMI patient to a high BMI patient (or from high to low), eruption patterns and risk factors may change.
INTRODUCTION: Overweight is a well-established risk factor for hidradenitis suppurativa (HS). In this cross-sectional study, we compare HS patients with a high body mass index (BMI) with HS patients with a low BMI to investigate differences in disease characteristics. MATERIALS AND METHOD:Patients were recruited from 17 dermatological centres from four continents. A total of 246 patients with a BMI below 25 were compared to 205 patients with a BMI of above 35. RESULTS:Patients with a high BMI suffered more severe disease (Hurley, physician global assessment, number of areas affected and patient-reported severity (PRS), P < 0.001 for all). There was no difference in smoking (P = 0.783) nor in family history (P = 0.088). In both low and high BMI patients, early onset of HS was a predictor of positive family history (P < 0.001, for each). For low BMI patients, an increase in BMI significantly increased PRS (P < 0.001). For patients with a high BMI, number of pack-years significantly increased PRS (P = 0.001). Cluster analysis of eruption patterns was location specific for low BMI patients but severity specific for high BMI patients. DISCUSSION: Patients with a low and high BMI could represent two clinically different subtypes. We suggest a non-linear relationship between BMI and impact of HS. As patients go from a low BMI patient to a high BMI patient (or from high to low), eruption patterns and risk factors may change.
Authors: Peter Theut Riis; Ditte Marie Saunte; Viktoria Sigsgaard; Axel Patrice Villani; Philippe Guillem; José C Pascual; Naomi N Kappe; Annika M J D Vanlaerhoven; Hessel H van der Zee; Errol P Prens; Moetaz El-Domyati; Hossam Abdel-Wahab; Nayera Moftah; Rania Abdelghani; Eugenia Agut-Busquet; Jorge Romaní; Carol Hlela; Lerinza van den Worm; Vincenzo Bettoli; Giada Calamo; Mehmet Ali Gürer; Burcu Beksaç; Lukasz Matusiak; Amelia Glowaczewska; Jacek C Szepietowski; Lennart Emtestam; Jan Lapins; Hassan Riad Kottb; Mohammad Fatani; Lisa Weibel; Martin Theiler; Maïa Delage-Toriel; Thi Thanh Hong Lam; Aude Nassif; Pierre-Andre Becherel; Mateja Dolenc-Voljc; Nejib Doss; Dorra Bouazzi; Farida Benhadou; Veronique Del Marmol; Gregor B E Jemec Journal: Arch Dermatol Res Date: 2020-03-12 Impact factor: 3.017
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