Literature DB >> 28940650

Polygenic hazard scores in preclinical Alzheimer disease.

Chin Hong Tan1, Bradley T Hyman2, Jacinth J X Tan3, Christopher P Hess1, William P Dillon1, Gerard D Schellenberg4, Lilah M Besser5, Walter A Kukull5, Karolina Kauppi6, Linda K McEvoy6, Ole A Andreassen7, Anders M Dale6,8,9, Chun Chieh Fan9, Rahul S Desikan1,10.   

Abstract

Identifying asymptomatic older individuals at elevated risk for developing Alzheimer disease (AD) is of clinical importance. Among 1,081 asymptomatic older adults, a recently validated polygenic hazard score (PHS) significantly predicted time to AD dementia and steeper longitudinal cognitive decline, even after controlling for APOE ɛ4 carrier status. Older individuals in the highest PHS percentiles showed the highest AD incidence rates. PHS predicted longitudinal clinical decline among older individuals with moderate to high Consortium to Establish a Registry for Alzheimer's Disease (amyloid) and Braak (tau) scores at autopsy, even among APOE ɛ4 noncarriers. Beyond APOE, PHS may help identify asymptomatic individuals at highest risk for developing Alzheimer neurodegeneration. Ann Neurol 2017;82:484-488.
© 2017 American Neurological Association.

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Year:  2017        PMID： 28940650      PMCID： PMC5758043          DOI： 10.1002/ana.25029

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  15 in total

1.  The association between a polygenic Alzheimer score and cortical thickness in clinically normal subjects.

Authors:  Mert R Sabuncu; Randy L Buckner; Jordan W Smoller; Phil Hyoun Lee; Bruce Fischl; Reisa A Sperling
Journal:  Cereb Cortex       Date:  2011-12-13       Impact factor: 5.357

2.  Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset.

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Journal:  Am J Public Health       Date:  1998-09       Impact factor: 9.308

Review 3.  Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.

Authors:  Bruno Dubois; Harald Hampel; Howard H Feldman; Philip Scheltens; Paul Aisen; Sandrine Andrieu; Hovagim Bakardjian; Habib Benali; Lars Bertram; Kaj Blennow; Karl Broich; Enrica Cavedo; Sebastian Crutch; Jean-François Dartigues; Charles Duyckaerts; Stéphane Epelbaum; Giovanni B Frisoni; Serge Gauthier; Remy Genthon; Alida A Gouw; Marie-Odile Habert; David M Holtzman; Miia Kivipelto; Simone Lista; José-Luis Molinuevo; Sid E O'Bryant; Gil D Rabinovici; Christopher Rowe; Stephen Salloway; Lon S Schneider; Reisa Sperling; Marc Teichmann; Maria C Carrillo; Jeffrey Cummings; Cliff R Jack
Journal:  Alzheimers Dement       Date:  2016-03       Impact factor: 21.566

4.  The Clinical Dementia Rating (CDR): current version and scoring rules.

Authors:  J C Morris
Journal:  Neurology       Date:  1993-11       Impact factor: 9.910

5.  Cognitive domain decline in healthy apolipoprotein E epsilon4 homozygotes before the diagnosis of mild cognitive impairment.

Authors:  Richard J Caselli; Eric M Reiman; Dona E C Locke; Michael L Hutton; Joseph G Hentz; Charlene Hoffman-Snyder; Bryan K Woodruff; Gene E Alexander; David Osborne
Journal:  Arch Neurol       Date:  2007-09

6.  Age-dependent effects of APOE ε4 in preclinical Alzheimer's disease.

Authors:  Luke W Bonham; Ethan G Geier; Chun C Fan; Josiah K Leong; Lilah Besser; Walter A Kukull; John Kornak; Ole A Andreassen; Gerard D Schellenberg; Howard J Rosen; William P Dillon; Christopher P Hess; Bruce L Miller; Anders M Dale; Rahul S Desikan; Jennifer S Yokoyama
Journal:  Ann Clin Transl Neurol       Date:  2016-08-26       Impact factor: 4.511

7.  APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts.

Authors:  Jing Qian; Frank J Wolters; Alexa Beiser; Mary Haan; M Arfan Ikram; Jason Karlawish; Jessica B Langbaum; John M Neuhaus; Eric M Reiman; J Scott Roberts; Sudha Seshadri; Pierre N Tariot; Beth McCarty Woods; Rebecca A Betensky; Deborah Blacker
Journal:  PLoS Med       Date:  2017-03-21       Impact factor: 11.069

8.  Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score.

Authors:  Rahul S Desikan; Chun Chieh Fan; Yunpeng Wang; Andrew J Schork; Howard J Cabral; L Adrienne Cupples; Wesley K Thompson; Lilah Besser; Walter A Kukull; Dominic Holland; Chi-Hua Chen; James B Brewer; David S Karow; Karolina Kauppi; Aree Witoelar; Celeste M Karch; Luke W Bonham; Jennifer S Yokoyama; Howard J Rosen; Bruce L Miller; William P Dillon; David M Wilson; Christopher P Hess; Margaret Pericak-Vance; Jonathan L Haines; Lindsay A Farrer; Richard Mayeux; John Hardy; Alison M Goate; Bradley T Hyman; Gerard D Schellenberg; Linda K McEvoy; Ole A Andreassen; Anders M Dale
Journal:  PLoS Med       Date:  2017-03-21       Impact factor: 11.069

9.  Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.

Authors:  J C Lambert; C A Ibrahim-Verbaas; D Harold; A C Naj; R Sims; C Bellenguez; A L DeStafano; J C Bis; G W Beecham; B Grenier-Boley; G Russo; T A Thorton-Wells; N Jones; A V Smith; V Chouraki; C Thomas; M A Ikram; D Zelenika; B N Vardarajan; Y Kamatani; C F Lin; A Gerrish; H Schmidt; B Kunkle; M L Dunstan; A Ruiz; M T Bihoreau; S H Choi; C Reitz; F Pasquier; C Cruchaga; D Craig; N Amin; C Berr; O L Lopez; P L De Jager; V Deramecourt; J A Johnston; D Evans; S Lovestone; L Letenneur; F J Morón; D C Rubinsztein; G Eiriksdottir; K Sleegers; A M Goate; N Fiévet; M W Huentelman; M Gill; K Brown; M I Kamboh; L Keller; P Barberger-Gateau; B McGuiness; E B Larson; R Green; A J Myers; C Dufouil; S Todd; D Wallon; S Love; E Rogaeva; J Gallacher; P St George-Hyslop; J Clarimon; A Lleo; A Bayer; D W Tsuang; L Yu; M Tsolaki; P Bossù; G Spalletta; P Proitsi; J Collinge; S Sorbi; F Sanchez-Garcia; N C Fox; J Hardy; M C Deniz Naranjo; P Bosco; R Clarke; C Brayne; D Galimberti; M Mancuso; F Matthews; S Moebus; P Mecocci; M Del Zompo; W Maier; H Hampel; A Pilotto; M Bullido; F Panza; P Caffarra; B Nacmias; J R Gilbert; M Mayhaus; L Lannefelt; H Hakonarson; S Pichler; M M Carrasquillo; M Ingelsson; D Beekly; V Alvarez; F Zou; O Valladares; S G Younkin; E Coto; K L Hamilton-Nelson; W Gu; C Razquin; P Pastor; I Mateo; M J Owen; K M Faber; P V Jonsson; O Combarros; M C O'Donovan; L B Cantwell; H Soininen; D Blacker; S Mead; T H Mosley; D A Bennett; T B Harris; L Fratiglioni; C Holmes; R F de Bruijn; P Passmore; T J Montine; K Bettens; J I Rotter; A Brice; K Morgan; T M Foroud; W A Kukull; D Hannequin; J F Powell; M A Nalls; K Ritchie; K L Lunetta; J S Kauwe; E Boerwinkle; M Riemenschneider; M Boada; M Hiltuenen; E R Martin; R Schmidt; D Rujescu; L S Wang; J F Dartigues; R Mayeux; C Tzourio; A Hofman; M M Nöthen; C Graff; B M Psaty; L Jones; J L Haines; P A Holmans; M Lathrop; M A Pericak-Vance; L J Launer; L A Farrer; C M van Duijn; C Van Broeckhoven; V Moskvina; S Seshadri; J Williams; G D Schellenberg; P Amouyel
Journal:  Nat Genet       Date:  2013-10-27       Impact factor: 38.330

10.  Genetic Stratification to Identify Risk Groups for Alzheimer's Disease.

Authors:  Riccardo E Marioni; Archie Campbell; Saskia P Hagenaars; Reka Nagy; Carmen Amador; Caroline Hayward; David J Porteous; Peter M Visscher; Ian J Deary
Journal:  J Alzheimers Dis       Date:  2017       Impact factor: 4.472
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  21 in total

1.  Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition.

Authors:  Chin Hong Tan; Chun Chieh Fan; Elizabeth C Mormino; Leo P Sugrue; Iris J Broce; Christopher P Hess; William P Dillon; Luke W Bonham; Jennifer S Yokoyama; Celeste M Karch; James B Brewer; Gil D Rabinovici; Bruce L Miller; Gerard D Schellenberg; Karolina Kauppi; Howard A Feldman; Dominic Holland; Linda K McEvoy; Bradley T Hyman; David A Bennett; Ole A Andreassen; Anders M Dale; Rahul S Desikan
Journal:  Acta Neuropathol       Date:  2017-11-24       Impact factor: 17.088

2.  The Alzheimer's Disease Exposome.

Authors:  Caleb E Finch; Alexander M Kulminski
Journal:  Alzheimers Dement       Date:  2019-09-10       Impact factor: 21.566

3.  Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration.

Authors:  Chin Hong Tan; Luke W Bonham; Chun Chieh Fan; Elizabeth C Mormino; Leo P Sugrue; Iris J Broce; Christopher P Hess; Jennifer S Yokoyama; Gil D Rabinovici; Bruce L Miller; Kristine Yaffe; Gerard D Schellenberg; Karolina Kauppi; Dominic Holland; Linda K McEvoy; Walter A Kukull; Duygu Tosun; Michael W Weiner; Reisa A Sperling; David A Bennett; Bradley T Hyman; Ole A Andreassen; Anders M Dale; Rahul S Desikan
Journal:  Brain       Date:  2019-02-01       Impact factor: 13.501

Review 4.  Progress in Polygenic Composite Scores in Alzheimer's and Other Complex Diseases.

Authors:  Danai Chasioti; Jingwen Yan; Kwangsik Nho; Andrew J Saykin
Journal:  Trends Genet       Date:  2019-03-25       Impact factor: 11.639

5.  Sex Differences in the Genetic Architecture of Alzheimer's Disease.

Authors:  Logan Dumitrescu; Elizabeth Rose Mayeda; Kavya Sharman; Annah M Moore; Timothy J Hohman
Journal:  Curr Genet Med Rep       Date:  2019-01-21

6.  APOE-ε4 Shapes the Cerebral Organization in Cognitively Intact Individuals as Reflected by Structural Gray Matter Networks.

Authors:  Raffaele Cacciaglia; José Luis Molinuevo; Carles Falcón; Eider M Arenaza-Urquijo; Gonzalo Sánchez-Benavides; Anna Brugulat-Serrat; Kaj Blennow; Henrik Zetterberg; Juan Domingo Gispert
Journal:  Cereb Cortex       Date:  2020-06-01       Impact factor: 5.357

7.  Alzheimer's disease polygenic risk score as a predictor of conversion from mild-cognitive impairment.

Authors:  Sultan Chaudhury; Keeley J Brookes; Tulsi Patel; Abigail Fallows; Tamar Guetta-Baranes; James C Turton; Rita Guerreiro; Jose Bras; John Hardy; Paul T Francis; Rebecca Croucher; Clive Holmes; Kevin Morgan; A J Thomas
Journal:  Transl Psychiatry       Date:  2019-05-24       Impact factor: 6.222

8.  Gene- and age-informed screening for preclinical Alzheimer's disease trials.

Authors:  Barbara E Spencer; Leonardino A Digma; Robin G Jennings; James B Brewer
Journal:  Alzheimers Dement       Date:  2020-11-23       Impact factor: 21.566

Review 9.  Predictive Genetic Counseling for Neurodegenerative Diseases: Past, Present, and Future.

Authors:  Jill S Goldman
Journal:  Cold Spring Harb Perspect Med       Date:  2020-07-01       Impact factor: 5.159

10.  Combining Polygenic Hazard Score With Volumetric MRI and Cognitive Measures Improves Prediction of Progression From Mild Cognitive Impairment to Alzheimer's Disease.

Authors:  Karolina Kauppi; Chun Chieh Fan; Linda K McEvoy; Dominic Holland; Chin Hong Tan; Chi-Hua Chen; Ole A Andreassen; Rahul S Desikan; Anders M Dale
Journal:  Front Neurosci       Date:  2018-04-30       Impact factor: 4.677
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