San-Gang Wu1, Xu-Lin Liao2, Zhen-Yu He3, Li-Ying Tang2, Xue-Ting Chen2, Yan Wang4, Qin Lin5. 1. Department of Radiation Oncology, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Xiamen 361003, PR China. 2. Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Medical College, Xiamen University, Xiamen 361005, PR China. 3. Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, PR China. 4. Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, PR China. 5. Department of Radiation Oncology, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Xiamen 361003, PR China. Electronic address: linqin9531@126.com.
Abstract
OBJECTIVE: To investigate the demographic features, clinicopathological characteristics and treatment outcomes of patients with nasopharyngeal carcinoma (NPC) according to age at diagnosis. METHODS: We assessed demographic and clinicopathological variables extracted from the Surveillance, Epidemiology, and End Results database (2004-2014). The Cox proportional hazards regression model was used to perform univariate and multivariate analyses of NPC-related mortality (cause-specific survival). RESULTS: A total of 3880 patients were analyzed. Median age was 55-years-old; 108 (2.8%), 508 (13.1%), 1876 (48.4%), 1240 (32.0%), and 148 (3.8%) patients were aged 1-19, 20-39, 40-59, 60-79, and 80-99-years-old, respectively. Younger patients tended to be black and present with poorly/undifferentiated disease and advanced tumor and nodal category compared to older patients. Younger patients were more likely to receive chemotherapy than older patients. In multivariate analyses, age at diagnosis was an independent prognostic factor for cause-specific survival. Increasing age at diagnosis was associated with a significantly higher risk of NPC-related mortality. Compared to patients aged 1-19-years-old, the hazard ratios for patients aged 20-39, 40-59, 60-79, and 80-99-years-old were 2.030 (95% confidence interval 1.004-4.104), 2.871 (1.474-5.590), 4.443 (2.273-8.683), and 12.024 (5.855-24.695), respectively. With the exception of black patients (P=0.100), older age was associated with poor survival in all demographic and clinical subgroups. CONCLUSION: Although younger patients tended to have advanced disease at diagnosis, older age at diagnosis was associated with a higher risk of NPC-related mortality.
OBJECTIVE: To investigate the demographic features, clinicopathological characteristics and treatment outcomes of patients with nasopharyngeal carcinoma (NPC) according to age at diagnosis. METHODS: We assessed demographic and clinicopathological variables extracted from the Surveillance, Epidemiology, and End Results database (2004-2014). The Cox proportional hazards regression model was used to perform univariate and multivariate analyses of NPC-related mortality (cause-specific survival). RESULTS: A total of 3880 patients were analyzed. Median age was 55-years-old; 108 (2.8%), 508 (13.1%), 1876 (48.4%), 1240 (32.0%), and 148 (3.8%) patients were aged 1-19, 20-39, 40-59, 60-79, and 80-99-years-old, respectively. Younger patients tended to be black and present with poorly/undifferentiated disease and advanced tumor and nodal category compared to older patients. Younger patients were more likely to receive chemotherapy than older patients. In multivariate analyses, age at diagnosis was an independent prognostic factor for cause-specific survival. Increasing age at diagnosis was associated with a significantly higher risk of NPC-related mortality. Compared to patients aged 1-19-years-old, the hazard ratios for patients aged 20-39, 40-59, 60-79, and 80-99-years-old were 2.030 (95% confidence interval 1.004-4.104), 2.871 (1.474-5.590), 4.443 (2.273-8.683), and 12.024 (5.855-24.695), respectively. With the exception of black patients (P=0.100), older age was associated with poor survival in all demographic and clinical subgroups. CONCLUSION: Although younger patients tended to have advanced disease at diagnosis, older age at diagnosis was associated with a higher risk of NPC-related mortality.
Authors: Anaïs Jouin; Sylvie Helfre; Stéphanie Bolle; Line Claude; Anne Laprie; Emilie Bogart; Céline Vigneron; Hélène Potet; Anne Ducassou; Audrey Claren; François Georges Riet; Marie Pierre Castex; Cécile Faure-Conter; Brice Fresneau; Anne Sophie Defachelles; Daniel Orbach Journal: Strahlenther Onkol Date: 2019-04-08 Impact factor: 3.621