Literature DB >> 28936130

Stability of Systems with Stochastic Delays and Applications to Genetic Regulatory Networks.

Marcella M Gomez1, Mehdi Sadeghpour2, Matthew R Bennett3, Gábor Orosz2, Richard M Murray4.   

Abstract

The dynamics of systems with stochastically varying time delays are investigated in this paper. It is shown that the mean dynamics can be used to derive necessary conditions for the stability of equilibria of the stochastic system. Moreover, the second moment dynamics can be used to derive sufficient conditions for almost sure stability of equilibria. The results are summarized using stability charts that are obtained via semi-discretization. The theoretical methods are applied to simple gene regulatory networks where it is demonstrated that stochasticity in the delay can improve the stability of steady protein production.

Entities:  

Keywords:  genetic networks; stability; stochastic delay; systems biology

Year:  2016        PMID: 28936130      PMCID: PMC5603244          DOI: 10.1137/15M1031965

Source DB:  PubMed          Journal:  SIAM J Appl Dyn Syst        ISSN: 1536-0040            Impact factor:   2.316


  15 in total

1.  Oscillatory expression of Hes1, p53, and NF-kappaB driven by transcriptional time delays.

Authors:  Nicholas A M Monk
Journal:  Curr Biol       Date:  2003-08-19       Impact factor: 10.834

2.  Autoinhibition with transcriptional delay: a simple mechanism for the zebrafish somitogenesis oscillator.

Authors:  Julian Lewis
Journal:  Curr Biol       Date:  2003-08-19       Impact factor: 10.834

3.  A superresolution census of RNA polymerase.

Authors:  Stefan Klumpp
Journal:  Biophys J       Date:  2013-12-17       Impact factor: 4.033

4.  Controlling biological networks by time-delayed signals.

Authors:  Gábor Orosz; Jeff Moehlis; Richard M Murray
Journal:  Philos Trans A Math Phys Eng Sci       Date:  2010-01-28       Impact factor: 4.226

5.  The RNA chain elongation rate in Escherichia coli depends on the growth rate.

Authors:  U Vogel; K F Jensen
Journal:  J Bacteriol       Date:  1994-05       Impact factor: 3.490

6.  Stochastic kinetic analysis of developmental pathway bifurcation in phage lambda-infected Escherichia coli cells.

Authors:  A Arkin; J Ross; H H McAdams
Journal:  Genetics       Date:  1998-08       Impact factor: 4.562

7.  Synergistic dual positive feedback loops established by molecular sequestration generate robust bimodal response.

Authors:  Ophelia S Venturelli; Hana El-Samad; Richard M Murray
Journal:  Proc Natl Acad Sci U S A       Date:  2012-11-12       Impact factor: 11.205

8.  Delay-induced degrade-and-fire oscillations in small genetic circuits.

Authors:  William Mather; Matthew R Bennett; Jeff Hasty; Lev S Tsimring
Journal:  Phys Rev Lett       Date:  2009-02-13       Impact factor: 9.161

9.  Dual delayed feedback provides sensitivity and robustness to the NF-κB signaling module.

Authors:  Diane M Longo; Jangir Selimkhanov; Jeffrey D Kearns; Jeff Hasty; Alexander Hoffmann; Lev S Tsimring
Journal:  PLoS Comput Biol       Date:  2013-06-27       Impact factor: 4.475

10.  A fast, robust and tunable synthetic gene oscillator.

Authors:  Jesse Stricker; Scott Cookson; Matthew R Bennett; William H Mather; Lev S Tsimring; Jeff Hasty
Journal:  Nature       Date:  2008-10-29       Impact factor: 49.962

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