Giulia Genoni1, Veronica Menegon2, Gioel Gabrio Secco3, Michela Sonzini1, Massimiliano Martelli2, Matteo Castagno1, Roberta Ricotti1, Alice Monzani4, Michele Aronici2, Elena Grossini5, Carlo Di Mario6, Gianni Bona1, Simonetta Bellone1, Flavia Prodam1. 1. Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy. 2. Vascular Surgery, Maggiore della Carità University Hospital, Novara, Italy. 3. Interventional Cardiology, Santi Antonio, Biagio e Cesare Arrigo Hospital, Alessandria, Italy. 4. Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy. Electronic address: alice.monzani@med.uniupo.it. 5. Laboratory of Physiology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy. 6. Structural Interventional Cardiology Unit, Careggi University Hospital, Florence, Italy.
Abstract
INTRODUCTION: Childhood obesity is associated with cardiovascular abnormalities but little is known on the potential correlation between early cardiovascular and metabolic alterations. AIM: Aims of this study were 1) to evaluate early cardiovascular abnormalities in a large population of obese children and adolescents compared with a normal weight counterpart, 2) to investigate their potential association with insulin resistance (IR), serum uric acid (sUA) and metabolic syndrome (MetS). METHODS: This was a single-center case-control study. Eighty obese (OB) subjects (6-16years) and 20 normal weight (NW) matched controls were consecutively recruited. In the whole population we performed an anthropometric and a cardiovascular assessment. OB patients also underwent an OGTT and biochemical evaluations. RESULTS: OB children showed greater left atrial (LA) and ventricular (LV) dimensions and mass and higher carotid artery intima-media thickness (CIMT), compared with NW controls. The BMI z-score, waist circumference, IR and sUA were positively related with LA and LV dimensions and mass. OB subjects with MetS (46.3%) showed greater LA diameter (p=0.001) and LV area (p=0.01) and volume (p=0.04) compared with OB children without MetS. LA diameter and LV dimensions and mass were significantly dependent on the number of criteria for MetS. Mets, sUA and IR were significant predictors of left heart dimensions and mass in obese children. CONCLUSIONS: Obesity and MetS are associated with abnormal cardiovascular response during childhood. Hyperuricemia can be an early marker of cardiovascular dysfunction and the routine determination of circulating levels of sUA should be implemented during risk stratification among pediatric age.
INTRODUCTION: Childhood obesity is associated with cardiovascular abnormalities but little is known on the potential correlation between early cardiovascular and metabolic alterations. AIM: Aims of this study were 1) to evaluate early cardiovascular abnormalities in a large population of obesechildren and adolescents compared with a normal weight counterpart, 2) to investigate their potential association with insulin resistance (IR), serum uric acid (sUA) and metabolic syndrome (MetS). METHODS: This was a single-center case-control study. Eighty obese (OB) subjects (6-16years) and 20 normal weight (NW) matched controls were consecutively recruited. In the whole population we performed an anthropometric and a cardiovascular assessment. OBpatients also underwent an OGTT and biochemical evaluations. RESULTS:OBchildren showed greater left atrial (LA) and ventricular (LV) dimensions and mass and higher carotid artery intima-media thickness (CIMT), compared with NW controls. The BMI z-score, waist circumference, IR and sUA were positively related with LA and LV dimensions and mass. OB subjects with MetS (46.3%) showed greater LA diameter (p=0.001) and LV area (p=0.01) and volume (p=0.04) compared with OBchildren without MetS. LA diameter and LV dimensions and mass were significantly dependent on the number of criteria for MetS. Mets, sUA and IR were significant predictors of left heart dimensions and mass in obesechildren. CONCLUSIONS:Obesity and MetS are associated with abnormal cardiovascular response during childhood. Hyperuricemia can be an early marker of cardiovascular dysfunction and the routine determination of circulating levels of sUA should be implemented during risk stratification among pediatric age.
Authors: Maria Efthymia Katsa; Anastasios Ioannidis; Athanasios Sachlas; Ioannis Dimopoulos; Stylianos Chatzipanagiotou; Andrea Paola Rojas Gil Journal: Ann Pediatr Endocrinol Metab Date: 2019-09-30
Authors: Valter Paulo Neves Miranda; Paulo Roberto Dos Santos Amorim; Ronaldo Rocha Bastos; Karina Lúcia Ribeiro Canabrava; Márcio Vidigal Miranda Júnior; Fernanda Rocha Faria; Sylvia do Carmo Castro Franceschini; Maria do Carmo Gouveia Peluzio; Silvia Eloiza Priore Journal: Mediators Inflamm Date: 2020-07-09 Impact factor: 4.711