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Literature DB >> 2893412

Effects of the novel anxiolytics gepirone, buspirone and ipsapirone on free feeding and on feeding induced by 8-OH-DPAT.

Abstract

The effects of the novel anxiolytics gepirone, buspirone and ipsapirone on free feeding and on feeding induced by the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), were examined. Gepirone dose-dependently increased feeding 2 and 4 h after injection, the magnitude of the response being larger than previously observed with any other 5-HT1A receptor ligand. Previous studies have suggested that buspirone and ipsapirone can block some of the behavioural effects of 8-OH-DPAT. However, gepirone, buspirone and ipsapirone did not inhibit feeding induced by 8-OH-DPAT. These results indicate that gepirone is a very efficacious appetite stimulant in rats and suggest that gepirone, buspirone and ipsapirone act as 5-HT autoreceptor agonists in the feeding model.

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Year: 1987 PMID： 2893412 DOI： 10.1007/bf00187255

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

25 in total

1. 8-OH-DPAT-induced hyperphagia: its neural basis and possible therapeutic relevance.

Authors: C T Dourish; P H Hutson; G A Kennett; G Curzon
Journal: Appetite Date: 1986 Impact factor: 3.868

2. Serotonergic mechanisms in the behavioral effects of buspirone and gepirone.

Authors: A S Eison; M S Eison; M Stanley; L A Riblet
Journal: Pharmacol Biochem Behav Date: 1986-03 Impact factor: 3.533

3. Comparative neuropharmacology of buspirone and MJ-13805, a potential anti-anxiety drug.

Authors: B A McMillen; L A Mattiace
Journal: J Neural Transm Date: 1983 Impact factor: 3.575

4. Effects of 5-HT1A selective anxiolytics on lordosis behavior: interactions with progesterone.

Authors: S D Mendelson; B B Gorzalka
Journal: Eur J Pharmacol Date: 1986-12-16 Impact factor: 4.432

5. Brain serotonin receptors as a target for the putative anxiolytic TVX Q 7821.

Authors: J Traber; M A Davies; W U Dompert; T Glaser; T Schuurman; P R Seidel
Journal: Brain Res Bull Date: 1984-06 Impact factor: 4.077

6. The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rat.

Authors: M D Tricklebank; C Forler; J R Fozard
Journal: Eur J Pharmacol Date: 1984-11-13 Impact factor: 4.432

7. 8-Hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicits eating in free-feeding rats by acting on central serotonin neurons.

Authors: C Bendotti; R Samanin
Journal: Eur J Pharmacol Date: 1986-02-11 Impact factor: 4.432

8. Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists.

Authors: J S Sprouse; G K Aghajanian
Journal: Synapse Date: 1987 Impact factor: 2.562

9. Inhibition of serotonergic dorsal raphe neurons by systemic and iontophoretic administration of buspirone, a non-benzodiazepine anxiolytic drug.

Authors: C P VanderMaelen; G K Matheson; R C Wilderman; L A Patterson
Journal: Eur J Pharmacol Date: 1986-09-23 Impact factor: 4.432

10. Neurochemical and behavioural evidence for mediation of the hyperphagic action of 8-OH-DPAT by 5-HT cell body autoreceptors.

Authors: P H Hutson; C T Dourish; G Curzon
Journal: Eur J Pharmacol Date: 1986-10-07 Impact factor: 4.432

14 in total

1. 8-OH-DPAT specifically enhances feeding behaviour in mice: evidence from behavioural competition.

Authors: J K Shepherd; R J Rodgers
Journal: Psychopharmacology (Berl) Date: 1990 Impact factor: 4.530

2. Agmatine in the hypothalamic paraventricular nucleus stimulates feeding in rats: involvement of neuropeptide Y.

Authors: B G Taksande; N R Kotagale; K T Nakhate; P D Mali; D M Kokare; K Hirani; N K Subhedar; C T Chopde; R R Ugale
Journal: Br J Pharmacol Date: 2011-09 Impact factor: 8.739

3. Influence of taste and food texture on the feeding responses induced by 8-OH-DPAT and gepirone.

Authors: P J Fletcher; M H Zack; D V Coscina
Journal: Psychopharmacology (Berl) Date: 1991 Impact factor: 4.530

4. Evaluation of the dependence potential of the selective 5-H1A agonist ipsapirone in rats and of its effects on benzodiazepine withdrawal.

Authors: A J Goudie; M J Leathley
Journal: Psychopharmacology (Berl) Date: 1991 Impact factor: 4.530

5. Behavioural evidence that d-fenfluramine-induced anorexia in the rat is not mediated by the 5-HT1A receptor subtype.

Authors: S P Vickers; P G Clifton; C T Dourish
Journal: Psychopharmacology (Berl) Date: 1996-05 Impact factor: 4.530

6. The involvement of 5-hydroxytryptaminergic and dopaminergic mechanisms in the eating induced by buspirone, gepirone and ipsapirone.

Authors: P J Fletcher; M Davies
Journal: Br J Pharmacol Date: 1990-03 Impact factor: 8.739