Literature DB >> 28932846

A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(ii) cluster.

C Lu1, K Laws, A Eskandari, K Suntharalingam.   

Abstract

Tetranuclear copper(ii) complexes containing multiple diclofenac and Schiff base moieties, 1-4, are shown to kill bulk cancer cells and cancer stem cells (CSCs) with low micromolar potency. The most effective complex, 1, elicits its cytotoxic effect by elevating the intracellular reactive oxygen species (ROS) levels and inhibiting cyclooxygenase-2 (COX-2) expression.

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Year:  2017        PMID： 28932846     DOI： 10.1039/c7dt02789c

Source DB:  PubMed          Journal:  Dalton Trans        ISSN： 1477-9226            Impact factor:   4.390


  8 in total

1.  Anticancer activity, DNA binding and cell mechanistic studies of estrogen-functionalised Cu(II) complexes.

Authors:  Stephen Barrett; Michele De Franco; Andrew Kellett; Eithne Dempsey; Cristina Marzano; Andrea Erxleben; Valentina Gandin; Diego Montagner
Journal:  J Biol Inorg Chem       Date:  2019-10-26       Impact factor: 3.358

2.  In vitro cytotoxicity activity of novel Schiff base ligand-lanthanide complexes.

Authors:  Kavitha Andiappan; Anandhavelu Sanmugam; Easwaramoorthy Deivanayagam; K Karuppasamy; Hyun-Seok Kim; Dhanasekaran Vikraman
Journal:  Sci Rep       Date:  2018-02-14       Impact factor: 4.379

3.  Delivery of an immunogenic cell death-inducing copper complex to cancer stem cells using polymeric nanoparticles.

Authors:  Ginevra Passeri; Joshua Northcote-Smith; Kogularamanan Suntharalingam
Journal:  RSC Adv       Date:  2022-02-11       Impact factor: 3.361

4.  Polypyridyl Zinc(II)-Indomethacin Complexes with Potent Anti-Breast Cancer Stem Cell Activity.

Authors:  Tiffany K Rundstadler; Arvin Eskandari; Sarah M Norman; Kogularamanan Suntharalingam
Journal:  Molecules       Date:  2018-09-04       Impact factor: 4.411

5.  A reactive oxygen species-generating, cancer stem cell-potent manganese(ii) complex and its encapsulation into polymeric nanoparticles.

Authors:  Arvin Eskandari; Kogularamanan Suntharalingam
Journal:  Chem Sci       Date:  2019-07-02       Impact factor: 9.825

6.  Phenethyl Isothiocyanate Suppresses Stemness in the Chemo- and Radio-Resistant Triple-Negative Breast Cancer Cell Line MDA-MB-231/IR Via Downregulation of Metadherin.

Authors:  Yen Thi-Kim Nguyen; Jeong Yong Moon; Meran Keshawa Ediriweera; Somi Kim Cho
Journal:  Cancers (Basel)       Date:  2020-01-22       Impact factor: 6.639

7.  Immunogenic Cell Death of Breast Cancer Stem Cells Induced by an Endoplasmic Reticulum-Targeting Copper(II) Complex.

Authors:  Pooja Kaur; Alice Johnson; Joshua Northcote-Smith; Chunxin Lu; Kogularamanan Suntharalingam
Journal:  Chembiochem       Date:  2020-09-22       Impact factor: 3.164

8.  Breast Cancer Stem Cell Potency of Nickel(II)-Polypyridyl Complexes Containing Non-steroidal Anti-inflammatory Drugs.

Authors:  Catherine J Feld; Alice Johnson; Zhiyin Xiao; Kogularamanan Suntharalingam
Journal:  Chemistry       Date:  2020-09-30       Impact factor: 5.236
  8 in total

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