Literature DB >> 28932642

TREX1 dictates the immune fate of irradiated cancer cells.

Claire Vanpouille-Box1, Silvia C Formenti1, Sandra Demaria1,2.   

Abstract

The optimal radiation dose and fractionation to induce anti-tumor immunity remain elusive. We recently found that the exonuclease TREX1 abrogates the immunogenicity of irradiated cancer cells by degrading interferon-stimulatory cytosolic dsDNA. TREX1 upregulation by radiation dose per fraction beyond a threshold of 10-12 Gy results in poor synergy with immune checkpoint blockers.

Entities:  

Keywords:  STING; abscopal effect; cGAS; immune checkpoint blockers; nucleic acids sensing; radiotherapy; type I interferon

Year:  2017        PMID： 28932642      PMCID： PMC5599078          DOI： 10.1080/2162402X.2017.1339857

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  8 in total

Review 1.  Role of Local Radiation Therapy in Cancer Immunotherapy.

Authors:  Sandra Demaria; Encouse B Golden; Silvia C Formenti
Journal:  JAMA Oncol       Date:  2015-12       Impact factor: 31.777

2.  STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.

Authors:  Seng-Ryong Woo; Mercedes B Fuertes; Leticia Corrales; Stefani Spranger; Michael J Furdyna; Michael Y K Leung; Ryan Duggan; Ying Wang; Glen N Barber; Katherine A Fitzgerald; Maria-Luisa Alegre; Thomas F Gajewski
Journal:  Immunity       Date:  2014-11-05       Impact factor: 31.745

3.  Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody.

Authors:  M Zahidunnabi Dewan; Ashley E Galloway; Noriko Kawashima; J Keith Dewyngaert; James S Babb; Silvia C Formenti; Sandra Demaria
Journal:  Clin Cancer Res       Date:  2009-08-25       Impact factor: 12.531

4.  Trex1 prevents cell-intrinsic initiation of autoimmunity.

Authors:  Daniel B Stetson; Joan S Ko; Thierry Heidmann; Ruslan Medzhitov
Journal:  Cell       Date:  2008-08-22       Impact factor: 41.582

5.  Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.

Authors:  Pu Gao; Manuel Ascano; Yang Wu; Winfried Barchet; Barbara L Gaffney; Thomas Zillinger; Artem A Serganov; Yizhou Liu; Roger A Jones; Gunther Hartmann; Thomas Tuschl; Dinshaw J Patel
Journal:  Cell       Date:  2013-05-03       Impact factor: 41.582

6.  Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ dendritic cells.

Authors:  Mercedes B Fuertes; Aalok K Kacha; Justin Kline; Seng-Ryong Woo; David M Kranz; Kenneth M Murphy; Thomas F Gajewski
Journal:  J Exp Med       Date:  2011-09-19       Impact factor: 14.307

7.  Type I interferon is selectively required by dendritic cells for immune rejection of tumors.

Authors:  Mark S Diamond; Michelle Kinder; Hirokazu Matsushita; Mona Mashayekhi; Gavin P Dunn; Jessica M Archambault; Hsiaoju Lee; Cora D Arthur; J Michael White; Ulrich Kalinke; Kenneth M Murphy; Robert D Schreiber
Journal:  J Exp Med       Date:  2011-09-19       Impact factor: 14.307

8.  DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity.

Authors:  Claire Vanpouille-Box; Amandine Alard; Molykutty J Aryankalayil; Yasmeen Sarfraz; Julie M Diamond; Robert J Schneider; Giorgio Inghirami; C Norman Coleman; Silvia C Formenti; Sandra Demaria
Journal:  Nat Commun       Date:  2017-06-09       Impact factor: 14.919
  8 in total
  35 in total

1.  Harnessing radiation to improve immunotherapy: better with particles?

Authors:  Marco Durante; Silvia Formenti
Journal:  Br J Radiol       Date:  2019-07-22       Impact factor: 3.039

2.  The Aftermath of Surviving Acute Radiation Hematopoietic Syndrome and its Mitigation.

Authors:  Ewa D Micewicz; Keisuke S Iwamoto; Josephine A Ratikan; Christine Nguyen; Michael W Xie; Genhong Cheng; Gayle M Boxx; Elisa Deriu; Robert D Damoiseaux; Julian P Whitelegge; Piotr P Ruchala; Rozeta Avetisyan; Michael E Jung; Greg Lawson; Elizabeta Nemeth; Tomas Ganz; James W Sayre; William H McBride; Dörthe Schaue
Journal:  Radiat Res       Date:  2019-02-07       Impact factor: 2.841

Review 3.  Combining Heavy-Ion Therapy with Immunotherapy: An Update on Recent Developments.

Authors:  Alexander Helm; Daniel K Ebner; Walter Tinganelli; Palma Simoniello; Alessandra Bisio; Valentina Marchesano; Marco Durante; Shigeru Yamada; Takashi Shimokawa
Journal:  Int J Part Ther       Date:  2018-09-21

Review 4.  Emerging biomarkers for the combination of radiotherapy and immune checkpoint blockers.

Authors:  Claire Lhuillier; Claire Vanpouille-Box; Lorenzo Galluzzi; Silvia Chiara Formenti; Sandra Demaria
Journal:  Semin Cancer Biol       Date:  2017-12-16       Impact factor: 15.707

Review 5.  STING pathway agonism as a cancer therapeutic.

Authors:  Blake A Flood; Emily F Higgs; Shuyin Li; Jason J Luke; Thomas F Gajewski
Journal:  Immunol Rev       Date:  2019-07       Impact factor: 12.988

Review 6.  Role of modern radiotherapy in managing patients with hepatocellular carcinoma.

Authors:  Liang-Cheng Chen; Hon-Yi Lin; Shih-Kai Hung; Wen-Yen Chiou; Moon-Sing Lee
Journal:  World J Gastroenterol       Date:  2021-05-28       Impact factor: 5.742

Review 7.  Radiation-Induced Immunity and Toxicities: The Versatility of the cGAS-STING Pathway.

Authors:  Julie Constanzo; Julien Faget; Chiara Ursino; Christophe Badie; Jean-Pierre Pouget
Journal:  Front Immunol       Date:  2021-05-17       Impact factor: 7.561

Review 8.  A narrative review of combined stereotactic ablative radiotherapy and immunotherapy in metastatic non-small cell lung cancer.

Authors:  Zarique Z Akanda; Paul J Neeson; Thomas John; Stephen Barnett; Gerard G Hanna; Alistair Miller; Ross Jennens; Shankar Siva
Journal:  Transl Lung Cancer Res       Date:  2021-06

9.  Electrotransfer of Different Control Plasmids Elicits Different Antitumor Effectiveness in B16.F10 Melanoma.

Authors:  Masa Bosnjak; Tanja Jesenko; Urska Kamensek; Gregor Sersa; Jaka Lavrencak; Loree Heller; Maja Cemazar
Journal:  Cancers (Basel)       Date:  2018-01-29       Impact factor: 6.639

10.  Immunofluorescence microscopy-based assessment of cytosolic DNA accumulation in mammalian cells.

Authors:  Ai Sato; Aitziber Buque; Takahiro Yamazaki; Norma Bloy; Giulia Petroni; Lorenzo Galluzzi
Journal:  STAR Protoc       Date:  2021-05-18
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